A5076369964- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Dermatology and Skin Diseases
University Hospital Cologne
2021
University of Cologne
2021
Herpes simplex virus 1 (HSV-1) enters its human host via the skin and mucosa. The open question is how invades this highly protective tissue in vivo to approach receptors epidermis initiate infection. Here, we performed ex infection studies investigate susceptible dermis are HSV-1 whether wounding facilitates viral invasion. Upon of complete skin, only sample edges with integrity loss demonstrated infected cells. After removal dermis, efficiently invaded basal layer and, from there, gained...
Abstract Herpes simplex virus 1 (HSV-1) enters its human host via the skin or mucosa. The open question is how invades this highly protective tissue in vivo to approach receptors epidermis and initiate infection. Here, we performed ex infection studies investigate susceptible dermis are HSV-1 whether wounding facilitates viral invasion. Upon of complete skin, only sample edges demonstrated infected cells. After removal dermis, efficiently invaded basal layer, from there, gained access...