A5051099498- Cardiac and Coronary Surgery Techniques
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Thermal Regulation in Medicine
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Cardiac Structural Anomalies and Repair
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Climate Change and Health Impacts
- Blood transfusion and management
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Cardiac Valve Diseases and Treatments
- Anesthesia and Neurotoxicity Research
- Airway Management and Intubation Techniques
- Acute Myocardial Infarction Research
- Thermoregulation and physiological responses
- Aortic aneurysm repair treatments
- Cardiac Imaging and Diagnostics
- Aortic Thrombus and Embolism
Karolinska Institutet
2013-2024
Karolinska University Hospital
2012-2022
Goethe University Frankfurt
2004-2022
Université de Bordeaux
2022
Ghent University Hospital
2022
Harefield Hospital
2022
Inserm
2022
Stockholm South General Hospital
2016
Linden Photonics (United States)
2009
Stockholm County Council
2009
The risks that the presence of air microemboli implies in open-heart surgery have recently been emphasized by reports their number is correlated with degree postoperative neuropsychological disorder. Therefore, we studied effect CO2 insufflation into cardiothoracic wound on incidence and behavior heart ascending aorta.Twenty patients undergoing single-valve were randomly divided 2 groups. Ten insufflated via a gas diffuser, 10 not. Microemboli ascertained intraoperative transesophageal...
Human alveolar macrophages have exceptionally high capacity to convert cholesterol into 27-hydroxycholesterol and cholestenoic acid by the sterol 27-hydroxylase mechanism. It is shown here that human lung has a higher content of relative than any other organ. In order evaluate importance mechanism for homeostasis in lung, production was investigated. Removal one reduced level circulation 48 ± 4% (P < 0.005). The levels pulmonary artery vein showed significant differences 0.002) with (108 16...
Paroxysms of atrial tachycardia are oftentimes associated with polyuria. The plasma levels the potent diuretic hormone, natriuretic peptide (ANP), elevated during episodes tachycardia, suggesting that ANP may play a role in mediating diuresis. mechanism enhanced secretion is not known. We examined effect altering pacing frequency isolated left rat atria on secretion. Atria were suspended between an electrode and hook connected to force transducer superfused medium 199. content superfusate...
Background— Clopidogrel, an irreversible platelet inhibitor, is used to treat patients with unstable angina. These often present for coronary artery bypass graft surgery (CABG) and are at increased risk perioperative bleeding. The current investigation evaluates the impact of aprotinin on bleeding transfusion requirements in clopidogrel-treated undergoing CABG. Methods Results— Seventy-five consecutive angina, administered clopidogrel <5 days before CABG, were randomized. Using a...
Abstract High prevalence of thrombotic events in severely ill COVID-19 patients have been reported. Pulmonary embolism as well microembolization vital organs may these individuals be direct causes death. The identification at high risk developing thrombosis lead to targeted, more effective prophylactic treatment. primary aim this study was test whether rotational thromboelastometry (ROTEM) admission indicates hypercoagulopathy and predicts the disease severity, assessed care level, patients....
Microemboli observed during coronary angiography can cause silent ischemic cerebral lesions. The aim of this study was to investigate if the number particulate microemboli is influenced by access site used.Fifty-one patients with stable angina pectoris referred for were randomized right radial or femoral arterial access. passing middle arteries continuously registered transcranial Doppler.The median (minimum-maximum range) numbers emboli significantly higher 10 (1-120) than 6 (1-19) More...
Abstract. Sarkar N, Rück A, Källner G, Y‐Hassan S, Blomberg P, Islam KB, van der Linden J, Lindblom D, Nygren AT, Lind B, Brodin L‐Å, Drvota V, Sylvén C (Karolinska Institute, Huddinge University Hospital, Novum, Stockholm, Sweden). Effects of intramyocardial injection phVEGF‐A 165 as sole therapy in patients with refractory coronary artery disease: 12‐month follow‐up. Angiogenic gene therapy. J Intern Med 2001; 250: 373–381. Objective. To test the safety and bioactivity after during Design....
We have analyzed the nucleotide sequences of 19 epsilon VH5 transcripts derived from in vivo isotype switched peripheral blood B cells three patients with atopic dermatitis. Comparison patients' own germline gene segments revealed that were both functional members human family and harbored numerous somatic mutations (range 5-36 per gene). In two patients, we detected clonally related but diverged transcripts, permitting construction a genealogical tree one patient. observed high proportion...
Aims: Movements of myocardial walls include components high velocity and short duration calling for a sampling rate in the acquisition tissue imaging data. This study aims at establishing optimal requirements measurements. Methods Results: In 16 healthy individuals, data were acquired frame 141–203 frames/s subsequent off-line analysis using software enabling reduction to 50%, 25% 12.5% initial rate. Different profile measured each these rates. The deviation results from values increased...
Cerebral damage is a major problem after reconstructive surgery of the aortic arch and descending aorta. Current protective strategies, including deep hypothermia retrograde cerebral perfusion, are used to prolong tolerated duration circulatory arrest, latter may also decrease possibility air/particle embolization. The aim current study was investigate whether neurochemical marker S-100 related when influence embolic injury has been minimized by use perfusion during last part arrest.Arterial...
The relation between cerebral blood flow and oxygen consumption was studied in six children during cardiac operations with profound hypothermia. A combination of topical cooling core used to reduce the nasopharyngeal temperature 15 degrees C. alpha-stat principle for pH management used. Blood decreased significantly temperature. At a C, reduced 25% awake level, corresponding 34% asleep value obtained 15-30 min after intubation. Oxygen value. During stable hypothermia, venous saturation...
The effects of 20 mg Zolpidem were studied in an open, polysomnographically-monitored 179 day trial 14 elderly psychiatric patients suffering from severe insomnia. After a placebo run-in 7 days, was given for days followed by 30-day wash-out period. Polysomnographic recordings (PSG) performed just before active treatment; 30, 90 and into the treatment period; at end Statistically significant improvements total sleep time, efficiency percentage rapid eye movement observed after 30 all which...