A5067066364- Circadian rhythm and melatonin
- Congenital heart defects research
- Neurogenesis and neuroplasticity mechanisms
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
Children's National
2020
University of Urbino
2017
Increasing evidence indicates that melatonin possesses protective effects toward different kinds of damage in various organs, including the brain. In a neonatal model hypoxia-ischemia (HI), was neuroprotective and preserved expression silent information regulator 1 (SIRT1) 24 hours after insult. This study aimed to gain more insight into role SIRT1 effect HI by studying early (1 hour) modulation its downstream targets, consequences on necrosis, apoptosis, autophagy, glial cell activation. We...
Abstract Signaling molecules that regulate neurodevelopmental processes in the early postnatal subventricular zone (SVZ) are critical for proper brain development yet remain poorly characterized. Here, we report Endothelin-1 (ET-1), a molecular component of SVZ, promotes radial glial cell maintenance and proliferation an autocrine manner via Notch signaling. Loss ET-1 signaling increases neurogenesis reduces oligodendrocyte progenitor (OPC) developing thereby altering cellular output stem...