A5042044486- Cancer Research and Treatments
- Escherichia coli research studies
- Virus-based gene therapy research
- Digestive system and related health
- CRISPR and Genetic Engineering
Klinikum rechts der Isar
2022
Technical University of Munich
2022
Abstract The B subunit of bacterial Shiga toxin (STxB) is nontoxic and has low immunogenicity. Its receptor, the glycosphingolipid Gb3/CD77, overexpressed on cell surface human colorectal cancer. We tested whether genetic porcine models, closely resembling anatomy pathophysiology, can be used to exploit tumor-targeting potential STxB. In accordance with findings cancer, pig model APC1311 bound STxB in tumors, but not normal colon or jejunum, except for putative enteroendocrine cells. primary...
<div>Abstract<p>The B subunit of bacterial Shiga toxin (STxB) is nontoxic and has low immunogenicity. Its receptor, the glycosphingolipid Gb<sub>3</sub>/CD77, overexpressed on cell surface human colorectal cancer. We tested whether genetic porcine models, closely resembling anatomy pathophysiology, can be used to exploit tumor-targeting potential STxB. In accordance with findings cancer, pig model <i>APC<sup>1311</sup></i> bound STxB in tumors,...
Supplementary Data from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
<div>Abstract<p>The B subunit of bacterial Shiga toxin (STxB) is nontoxic and has low immunogenicity. Its receptor, the glycosphingolipid Gb<sub>3</sub>/CD77, overexpressed on cell surface human colorectal cancer. We tested whether genetic porcine models, closely resembling anatomy pathophysiology, can be used to exploit tumor-targeting potential STxB. In accordance with findings cancer, pig model <i>APC<sup>1311</sup></i> bound STxB in tumors,...
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Data from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma
Supplementary Figure from Tumor Targeting with Bacterial Shiga Toxin B Subunit in Genetic Porcine Models for Colorectal Cancer and Osteosarcoma