A5100459932- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Microtubule and mitosis dynamics
- Breast Cancer Treatment Studies
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- IL-33, ST2, and ILC Pathways
- Kruppel-like factors research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Glutathione Transferases and Polymorphisms
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Cancer Research and Treatments
- Estrogen and related hormone effects
- Bacterial Infections and Vaccines
The University of Texas MD Anderson Cancer Center
2015-2024
Cancer Center of Hawaii
2024
University of Hawaiʻi at Mānoa
2024
University of Hawaii System
2024
Xizang Minzu University
2023
Yuhuangding Hospital
2020-2023
Qingdao University
2020-2023
People’s Hospital of Rizhao
2023
Jining Medical University
2023
Cancer Clinic
2020
Inflammatory breast cancer (IBC), the most aggressive subtype, is driven by an immunosuppressive tumor microenvironment (TME). Current treatments for IBC have limited efficacy. In a clinical trial (NCT01036087), anti-EGFR antibody combined with neoadjuvant chemotherapy produced highest pathological complete response rate ever reported in patients having triple-negative receptor status. We determined molecular and immunological mechanisms behind this superior outcome. Using novel humanized...
The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction central tolerance. Recent data suggest that survival mTECs extends beyond Aire+ cell population to form post-Aire mTEC and Hassall's corpuscles (HCs). nature function these structures, however, have remained unidentified. In this study, we characterized detail end-stage development HCs...
Inflammatory breast cancer (IBC) is the most lethal form of cancer, but basis for its aggressive properties are not fully understood. In this study, we report that high tumoral expression TIG1 (RARRES1), a functionally undefined membrane protein, confers shorter survival in patients with IBC. depletion decreased IBC cell proliferation, migration, and invasion vitro inhibited tumor growth cells vivo. We identified receptor tyrosine kinase, Axl, as TIG1-binding protein. interaction stablilized...
<h3>Importance</h3> Combining conventional chemotherapy with targeted therapy has been proposed to improve the pathologic complete response (pCR) rate in patients inflammatory breast cancer (IBC). Epidermal growth factor receptor (EGFR) expression is an independent predictor of low overall survival IBC. <h3>Objective</h3> To evaluate safety and efficacy anti-EGFR antibody panitumumab plus neoadjuvant primary human epidermal 2 (HER2)-negative <h3>Design, Setting, Participants</h3> Women...
Abstract Inflammatory breast cancer (IBC) is a clinically distinct and highly aggressive form of with rapid onset strong propensity to metastasize. The molecular mechanisms underlying the aggressiveness metastatic IBC are largely unknown. Herein, we report that decorin (DCN), small leucine-rich extracellular matrix proteoglycan, downregulated in tumors from patients IBC. Overexpression DCN cells markedly decreased migration, invasion, stem vitro inhibited tumor growth metastasis xenograft...
Significance Transcription factor II D (TFIID) is a multiprotein complex that essential for gene transcription. Together, TATA binding protein-associated 1 (TAF1), the biggest TFIID subunit, and TAF7 form an important control point transcriptional initiation. Although current models suggest binds TAF1 to block its intrinsic histone acetyltransferase (HAT) activity, almost nothing known about molecular basis of TAF1–TAF7 (TAF1/7) interaction activity. Here, we report atomic structure yeast...
Inflammatory breast cancer (IBC) is the most lethal and aggressive type of cancer, with a strong proclivity to metastasize, IBC-specific targeted therapies have not yet been developed. Epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target in IBC. However, mechanism behind effect EGFR therapy well defined. Here, we report that regulates IBC cell population expresses stem-like (CSC) markers through COX-2, key mediator inflammation whose expression correlates...
Lehmann et al have identified four molecular subtypes of triple-negative breast cancer (TNBC)-basal-like (BL) 1, BL2, mesenchymal (M), and luminal androgen receptor-and an immunomodulatory (IM) gene expression signature modifier. Our group previously showed that the response TNBC to neoadjuvant systemic chemotherapy (NST) differs by subtype, but whether NST affects subtype was unknown. Here, we tested hypothesis in patients without pathologic complete response, can change after NST....
<p>Somatic mutations identified by whole exome sequencing. Oncoplot representing the most common somatic assessed sequencing (WES) in tumors obtained from patients (n = 23) at time of diagnosis. Genes with occurring five or more are shown.</p>
<p>SUPPLEMENTARY FIGURE SF3. Box plots showing relationship between tumor mutational burden and pathological response.</p>
<p>SUPPLEMENTARY FIGURE SF2. Somatic mutations in genes commonly altered TNBC. Oncoplot showing somatic reported as prevalent other TNBC cohorts.</p>
Adipose stromal cells (ASCs) have been identified as a mesenchymal cell population recruited from white adipose tissue (WAT) by tumors and supporting cancer progression. We previously reported the existence of non-glycanated decorin isoform (ngDCN) marking mouse ASCs. peptide CSWKYWFGEC that binds to ngDCN hence can serve vehicle for ASC-directed therapy delivery. used hunter-killer peptides composed pro-apoptotic moiety deplete ASCs suppress growth tumors. Here, we report discovery human...
Inflammatory breast cancer (IBC) is the most pro-metastatic form of cancer. Better understanding its pathophysiology and identification actionable genetic alterations (AGAs) are crucial to improve systemic treatment. We aimed define DNA profiles IBC vs noninflammatory (non-IBC) clinical samples in terms copy number (CNAs), mutations, AGAs. applied targeted next-generation sequencing (tNGS) array-comparative genomic hybridization (aCGH) 57 50 non-IBC pooled these data with four public...
Abstract Purpose: Epidermal growth factor receptor (EGFR) pathway activation causes chemotherapy resistance, and inhibition of the EGFR sensitizes triple-negative breast cancer (TNBC) cells to in preclinical models. Given high prevalence overexpression TNBC, we conducted a single-arm phase II study panitumumab (anti-EGFR monoclonal antibody), carboplatin, paclitaxel as second neoadjuvant therapy (NAT) patients with doxorubicin cyclophosphamide (AC)–resistant TNBC (NCT02593175). Patients...
TBP-associated factor 4 (TAF4), an essential subunit of the TFIID complex acts as a coactivator for multiple transcriptional regulators, including Sp1 and CREB. However, little is known regarding structural properties TAF4 that lead to function. Here, we report crystal structure at 2.0-Å resolution human TAF4-TAFH domain, conserved domain among all metazoan TAF4, TAF4b, ETO family members. The hTAF4-TAFH adopts completely helical fold with large hydrophobic groove forms binding surface...