A5025847533- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Pharmaceutical and Antibiotic Environmental Impacts
- Per- and polyfluoroalkyl substances research
- Potato Plant Research
- Aldose Reductase and Taurine
- Analytical Chemistry and Chromatography
- Carcinogens and Genotoxicity Assessment
- Analytical chemistry methods development
- Environmental remediation with nanomaterials
- Birth, Development, and Health
- Plant Pathogens and Resistance
- Edible Oils Quality and Analysis
- Advanced oxidation water treatment
- Electrochemical sensors and biosensors
- Pharmacogenetics and Drug Metabolism
- Water Quality Monitoring and Analysis
- Cancer Immunotherapy and Biomarkers
- Advanced Photocatalysis Techniques
- Salivary Gland Disorders and Functions
- Electrochemical Analysis and Applications
- Cardiovascular Disease and Adiposity
- Oral and gingival health research
- Proteins in Food Systems
- Environmental Chemistry and Analysis
Technical University of Denmark
2018-2024
Baylor College of Medicine
2024
Fukui Prefectural University
2020-2022
University of Birmingham
2017-2019
Food Research Institute
2019
VNU University of Science
2015
Pohang University of Science and Technology
2014-2015
University of South Alabama
1996
University of California, Davis
1996
Dow Chemical (United States)
1991
Reaction phenotyping using recombinant human cytochromes P450 (P450) has great utility in early discovery. However, to fully realize the advantages of expressed P450s, extrapolation data from systems liver microsomes (HLM) is required. In this study, intersystem factors (ISEFs) were established for CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 11 probe substrates, based on substrate depletion and/or metabolite formation kinetics. The ISEF values determined multiple substrates similar...
Migration of per- and polyfluorinated alkyl substances (PFAS) from paper food contact materials (FCMs) can pose a consumer risk. However, risk assessment procedures typically do not consider PFAS contribution FCMs. Moreover, migration studies are often limited to one subclass or simplified by using simulants (FS). To assess the comprehensively, three subclasses (perfluorinated carboxylic acids/ sulfonic acids (PFCAs/PFSAs), polyfluoroalkyl phosphate esters (PAPs), fluorotelomer alcohols...
Per- and polyfluorinated alkyl substances (PFAS) can be found in food contact materials (FCMs). Therefore, migration into occurs contributes to human dietary exposure. Identification minimization of possible exposure-pathways these omnipresent potentially toxic chemicals are important mitigate health risks. Nonetheless, risk assessment procedures mostly limited considering the final PFAS concentrations without distinguishing contribution migration. Additionally, use simulants during tests...
Per- and polyfluorinated alkyl substances (PFAS) can be added to food contact materials (FCM) increase their water and/or grease repellent properties. Some well-known PFAS are perfluoroalkyl carboxylic acids (PFCA), sulfonic (PFSA), telomer alcohols (FTOH). Due the strength of carbon-fluorine bond, chemically very stable highly resistant biological degradation, posing a risk human health environment. To examine presence in paper-based FCM, various samples were collected, including popcorn...
Investigation into oven baked sweet potato and carrot fries at various temperatures times demonstrated the in situ formation of acrylamide an exponential manner. High levels were found these food items: up to 327 µg/kg for 190 °C 14 min, 99 13 min. Risk assessment via Margin Exposures estimation showed that consumption might pose adverse health effects consumers from toddlers adults, especially when prepared high above 175 a long time. Raw ingredient blanching immersion acetic acid prior...
The technical mixture of 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (TBECH or DBE-DBCH) and the pure β-TBECH isomer were subjected to in vitro biotransformation by human liver microsomes (HLM). After 60 min incubation, 5 potential metabolites TBECH identified microsomal assays both using ultraperformance liquid chromatography-Q-Exactive Orbitrap mass spectrometry. These include mono- dihydroxylated TriBECH as well an α-oxidation metabolite bromo-(1,2-dibromocyclohexyl)-acetic acid. Our...
Vegetable crisps are usually perceived to be a healthier alternative potato crisps, though thermal treatment can generate harmfull contaminants such as monochloropropanediol and glycidol fatty acid esters (MCPDEs GEs) or acrylamide in these products. This study is among the first investigate MCPDE, GEs, commercial potato, sweet parsnip, beetroot, carrot crisps. These were found all crisp samples on market. The novel vegetable (n = 16) showed substasntial higher concentrations than...
The involvement of cytochrome P450 2B6 (CYP2B6) to the in vitro and vivo metabolism bupropion has been well studied. In these investigations we performed a detailed phenotyping study characterize isoforms other than CYP2B6.A total nine metabolites were identified (M1–M9) incubations with cDNA-expressed P450s (rhCYP) human liver microsomes (HLM).Incubations rhCYP CYP2B6 as isoform responsible for formation hydroxybupropion (M3). CYP2C19 was involved primarily through alternate hydroxylation...
Perfluorooctane sulfonic acid (PFOS) belongs to a large group of anthropogenic compounds with high persistency named per- and polyfluorinated substances (PFAS). Widespread use from industry household appliances food-contact materials contributes PFAS exposure food as the primary source. Association studies suggest that vegetables fibre rich diet may reduce PFOS levels in humans, but experimental data remain limited. Here, we investigated uptake wash-out after seven days (3 mg/kg/day) two...
Khanh Hoang Nguyen* & Arvid Fromberg National Food Institute, Technical University of Denmark, Lyngby, Denmark