A5089560955- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Poisoning and overdose treatments
- Chemical synthesis and alkaloids
- Cancer, Stress, Anesthesia, and Immune Response
- Pharmacological Receptor Mechanisms and Effects
- Chemokine receptors and signaling
- Enzyme Production and Characterization
- Vascular Procedures and Complications
- Electrochemical Analysis and Applications
- Central Venous Catheters and Hemodialysis
- Vitamin K Research Studies
- Sulfur Compounds in Biology
- Science, Research, and Medicine
- Inflammatory mediators and NSAID effects
- Steroid Chemistry and Biochemistry
- Cholinesterase and Neurodegenerative Diseases
- Advanced Nanomaterials in Catalysis
- Drug-Induced Hepatotoxicity and Protection
- Neuroendocrine regulation and behavior
- Photochromic and Fluorescence Chemistry
- Electrolyte and hormonal disorders
- Clinical Nutrition and Gastroenterology
- Photoreceptor and optogenetics research
University of Copenhagen
2021-2025
Vrije Universiteit Amsterdam
2022-2024
Friedrich Schiller University Jena
2024
Luxembourg Institute of Health
2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2024
SARomics Biostructures (Sweden)
2022
Universidade Federal do Rio Grande do Sul
2013-2021
University of Rio Grande and Rio Grande Community College
2021
Clinica Universidad de Navarra
2017
Clínica Santa María
2017
Atypical chemokine receptor 3 (ACKR3), formerly referred to as CXCR7, is considered be an interesting drug target. In this study, we report on the synthesis, pharmacological characterization and radiolabeling of VUF15485, a new ACKR3 small-molecule agonist, that will serve important tool study <i>β</i>-arrestin-biased receptor. VUF15485 binds with nanomolar affinity (pIC<sub>50</sub> = 8.3) human ACKR3, measured in [<sup>125</sup>I]CXCL12 competition binding experiments. Moreover,...
The serotonin 2A receptor (5-HT
The serotonin 7 receptor (5-HT7R) regulates various processes in the central nervous system, including mood, learning, and circadian rhythm control, among others. Receptor activation can lead to of Gαs protein a subsequent increase intracellular cyclic adenosine monophosphate (cAMP). interaction with inverse agonists results decrease basal cAMP levels therefore downstream effect reduced neuronal excitability neurotransmission. Recently, pellotine (1a), Lophophora alkaloid, was unexpectedly...
The serotonin 2A receptor (5-HT2AR) is the most abundant excitatory in brain and primary target for serotonergic psychedelics. Despite its importance, receptor's mechanism of action structure-activity relationships are not fully understood. experimental 5-HT2AR structures have identified a hydrophobic tunnel lateral to orthosteric site, situated between transmembrane helices 4 5. Here, we examined this implications agonist pharmacology. characteristics key roles Phe2345x39 Gly2385x43 were...
Serotonergic psychedelics are described to have activation of the serotonin 2A receptor (5-HT2A) as their main pharmacological action. Despite relevance, molecular mechanisms underlying psychedelic effects induced by certain 5-HT2A agonists remain elusive. One proposed hypotheses is occurrence biased agonism, defined preferential signaling pathways over others. This study comparatively monitored efficiency a diverse panel 4-position-substituted (and N-benzyl-derived) phenylalkylamines induce...
ABSTRACT Atypical chemokine receptor 3 (ACKR3), formerly referred to as CXCR7, is considered be an interesting drug target. In this study we report on the synthesis, pharmacological characterization and radiolabeling of VUF15485, a new ACKR3 small-molecule agonist, that will serve important tool β-arrestin-biased receptor. VUF15485 binds with nanomolar affinity (pIC 50 = 8.3) human ACKR3, measured in [ 125 I]CXCL12 competition binding experiments. Moreover, BRET-based β-arrestin2 recruitment...
1-D nanostructures are promising materials for development of electrochemical devices offering benefits such as fast electron transfer rates and large surface areas.Copper oxide nanofibers (CuO-NFs) synthesized by electrospinning technique subsequent thermal treatment, were used to modify paraffin-impregnated graphite electrode (PIGE) a sensitive non-enzymatic glucose detection.The structure morphology CuO-NFs characterized scanning microscopy transmission microscopy.The electrocatalytic...
Se presenta nuestra experiencia en, aproximadamente, cincuenta estudios vasculares realizados en fistulas arterio-venosas de pacientes hemodiálisis. La técnica exploración se detalla ampliamente.
 
 Creemos que la incorporación angiografía por sustracción digital el diagnóstico a esta patología ha supuesto un gran avance, ya las imágenes obtenidas son excelente calidad con baja cantidad contraste.
Abstract Gold nanoparticles of different morphologies have been synthesized on a silica‐based organic‐inorganic hybrid material for catalytic applications. The gold formations proceed through in situ chemical reduction the AuCl 4 − anions previously adsorbed 3‐(1‐imidazolyl)propyl‐silsesquioxane, which plays role substrate and stabilizer. Two distinct reducing agents, sodium citrate borohydride, were employed to generate sizes. UV‐vis diffuse reflectance as well transmission electron...
Photoswitchable (PSW) molecules offer an attractive opportunity for the optical control of biological processes. However, successful design such compounds remains a challenging multioptimization endeavor, resulting in several target classes still relatively poorly explored by photoswitchable ligands, as is case G protein-coupled receptors (GPCRs). Here, we present PSW-Designer, fully open-source computational platform, implemented KNIME Analytics Platform, to and virtually screen novel...
Este trabajo trata de resaltar la importancia tomografía oblicua del tórax en el estudio los hilios pulmonares. 
 Se muestran fundamentos técnicos para su realización, describiendo igualmente anatomía hiliar y comentándose las principales indicaciones. Como complemento, se presentan algunos casos clínicos que esta técnica fue utilidad diagnóstica.
Se presenta un caso de síndrome cava superior producido por compresión aneurisma disecante aorta ascendente; habiéndose llegado al diagnóstico angiografía sustracción digital.