A5080181066- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
Université Clermont Auvergne
2022-2024
Imagerie Moléculaire et Stratégies Théranostiques
2022-2024
Inserm
2022-2024
Abstract Glioma are clinically challenging tumors due to their location and invasiveness nature, which often hinder complete surgical resection. The evaluation of the isocitrate dehydrogenase mutation status has become crucial for effective patient stratification. Through a transdisciplinary approach, we have developed an 18 F-labeled ligand non-invasive assessment IDH1R132H variant by using positron emission tomography (PET) imaging. In this study, successfully prepared diastereomerically...
Isocitrate dehydrogenases (IDHs) are metabolic enzymes commonly mutated in human cancers (glioma, acute myeloid leukaemia, chondrosarcoma, and intrahepatic cholangiocarcinoma). These variants of IDH (mIDH) acquire a neomorphic activity, namely, conversion α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate involved tumourigenesis. Thus, mIDHs have emerged as highly promising therapeutic targets, several mIDH specific inhibitors been developed. However, evaluation status, currently...