A5021374673- Synthesis and Reactions of Organic Compounds
- Analytical Chemistry and Chromatography
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Analytical Methods in Pharmaceuticals
- Chemical synthesis and pharmacological studies
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Eicosanoids and Hypertension Pharmacology
- Chemical Reaction Mechanisms
- Guidance and Control Systems
- Inflammatory mediators and NSAID effects
- Sports Dynamics and Biomechanics
- Analytical Chemistry and Sensors
- Computational Drug Discovery Methods
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Experimental and Theoretical Physics Studies
- Synthesis and pharmacology of benzodiazepine derivatives
- Metabolism and Genetic Disorders
- Pharmacogenetics and Drug Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Surface and Contact Lens
- Synthesis and Reactivity of Heterocycles
- Cancer therapeutics and mechanisms
- Quantum optics and atomic interactions
Physical and Technical Institute
2023
Ioffe Institute
2021
Peoples' Friendship University of Russia
2013-2020
Russian New University
2020
ITMO University
2015-2019
Moscow Power Engineering Institute
2018
Ministry of Health of the Russian Federation
2018
Baltic State Technical University Voenmeh
2015
Yaroslavl State Agricultural Academy
2011-2014
Sechenov University
2008-2013
Hyaluronic acid (HA), a major glycosaminoglycan of the extracellular matrix, has cell signaling functions that are dependent on its molecular weight. Anti-inflammatory effects for high-molecular-weight (HMW) HA and pro-inflammatory low-molecular-weight (LMW) were found various myeloid cells, including microglia. Astrocytes cells ectodermal origin play pivotal role in brain inflammation, but link between with different weights an inflammatory response these is not clear. We tested LMW HMW rat...
Although many neurological and psychiatric disorders reveal clear sex-dependent variations, the molecular mechanism of this process is not enough. Astrocytes are involved in response neural tissue to injury inflammation, produce steroid hormones, sense presence. To explore hypothesis that astrocytes may participate sex-mediated differences inflammatory responses, we have examined whether male female primary rat show different responses lipopolysaccharide (LPS) as a toll-like receptor 4...
Ocular inflammation contributes to the pathogenesis of blind-causing retinal degenerative diseases, such as age-related macular degeneration (AMD) or photic maculopathy. Here, we report on inflammatory mechanisms that are associated with induced by bright visible light, which were revealed while using a rabbit model. Histologically and electrophysiologically noticeable retina is preceded accompanied oxidative stress inflammation, evidenced granulocyte infiltration edema in this tissue, well...
Functional phenotypes, which cells can acquire depending on the microenvironment, are currently focus of investigations into new anti-inflammatory therapeutic approaches. Glial cells, microglia, and astrocytes major participants in neuroinflammation, but their roles differ, as microglia mesodermal origin, while ectodermal origin. The inflammatory phenotype be modulated by ω-6- ω-3-polyunsaturated fatty acid-derived oxylipins, although data changes oxylipin profiles different cell adaptations...
A phenomenon of endotoxin tolerance where prior exposure cells to minute amounts lipopolysaccharide (LPS) causes them become refractory a subsequent high-amount challenge is well described for innate immune such as monocytes/macrophages, but it still obscure brain cells. We exposed primary rat cortical astrocytes long-term low-grade concentration LPS, followed by stimulation with middle-grade LPS. Inflammatory markers, i.e., pro-inflammatory cytokine TNFα, inducible enzymes COX-2 and iNOS,...
The ultraviolet (UV) B-induced damage of the eye surface experimental animals (rabbits) includes loss corneal epithelium, apoptosis keratocytes and stromal edema. These changes are accompanied by clinically histologically manifested inflammation, neutrophil infiltration, exudation anterior chamber eye. According to mass spectrometric analysis, UV-induced is associated with pronounced in lipid composition tears, including a decrease amount arachidonic acid prostaglandin E2 an increase...
The aim of the study is to evaluate metabolism progestin drug Gestobutanoil in experiment with administration tablet dosage form containing (2 mg), experimental animals (rats and rabbits).Materials Methods.There was performed analysis biomatrix obtained from different species animals: female rats weighing 200.0±60.0g rabbits 3.0±0.2kg, which were administered doses drug, single or multiple.Metabolites identified using high performance liquid chromatography-mass spectrometry...
The synthesis of signal lipids, including eicosanoids, is not fully understood, although it key to the modulation various inflammatory states. Recently, isotopologues essential polyunsaturated fatty acids (PUFAs) deuterated at bis-allylic positions (D-PUFAs) have been proposed as inhibitors non-enzymatic lipid peroxidation (LPO) in disease models. Arachidonic acid (AA, 20:4 n-6) main precursor several classes which are produced by cyclooxygenases (COX) and lipoxygenases (LOX). In this study...