A5078639405- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood donation and transfusion practices
- Nerve injury and regeneration
- Traumatic Brain Injury and Neurovascular Disturbances
- Phosphodiesterase function and regulation
- Lower Extremity Biomechanics and Pathologies
- Traumatic Brain Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Osteoarthritis Treatment and Mechanisms
- Blood groups and transfusion
- Hemodynamic Monitoring and Therapy
- Neuropeptides and Animal Physiology
- Total Knee Arthroplasty Outcomes
- Cardiac Arrest and Resuscitation
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Healthcare cost, quality, practices
- Neuroscience and Neural Engineering
- Hip disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Hospital Admissions and Outcomes
- Pluripotent Stem Cells Research
Johns Hopkins University
2017-2024
Johns Hopkins Medicine
2017-2024
New York Medical College
2005-2007
Oberlin College
2006
Cardiovascular Research Center
2005
Temple University
2005
San Diego State University
2005
Treating Arabidopsis roots with exogenous auxin results in dramatic changes cellular processes including de novo induction of lateral which later emerge through the overlying cells. Microarray experiments reveal approximately 80 genes that are substantially up-regulated root over first 12 h following treatment. We hypothesize observed increase expression pectate lyase family leads to degradation pectin-rich middle lamellae, allowing cells parent separate cleanly. Differences degree pectin...
Cytoplasmic overexpression of Akt in the heart results a myopathy characterized by organ and myocyte hypertrophy. Conversely, nuclear-targeted does not lead to cardiac hypertrophy, but cellular basis this distinct phenotype remains be determined. Similarly, whether affects ventricular performance mechanics, calcium metabolism, electrical properties myocytes is unknown. Moreover, expression state phosphorylation regulatory proteins implicated cycling contractility are altered has been...
It is widely held that injured neurons in the central nervous system do not undergo axonal regrowth. However, there mounting evidence serotonin axons are a notable exception. Serotonin long‐distance regrowth neocortex after amphetamine lesion, and, following penetrating stab injury, they can regrow from cut ends to traverse rift. Traumatic brain injury (TBI) clinically prevalent and lead pathologies, such as depression, related serotonergic dysfunction. Thus, whether TBI an important...
Abstract Background Massive transfusions are associated with a high mortality rate, but there is little evidence indicating when such efforts futile. The purpose of this study was to identify clinical variables that could be used as futility indicators in massively transfused patients. Methods We retrospectively analyzed 138 adult surgical patients at our institution receiving massive transfusion (2016–2019). Peak lactate and nadir pH within 24 h initiation, along other variables, were...
BACKGROUND Patient blood management (PBM) is especially applicable in major spine surgery, during which bleeding and transfusion are common. What remains unclear this setting the overall impact of bundled PBM measures on requirements clinical outcomes. We compared these outcomes before after implementing a program. STUDY DESIGN AND METHODS conducted retrospective review 928 adult complex surgery patients performed by single surgeon between January 2009 June 2016. Although were phased over...
The association between body mass index (BMI) and severity of osteochondritis dissecans (OCD) the knee at presentation is poorly understood.
We report 2 cases of gastrointestinal bleeding and profound anemia in Jehovah’s Witness patients (with nadir hemoglobin 2.1 2.8 g/dL), both whom survived until discharge to home. Management included supportive care, antifibrinolytics, an aggressive erythropoietic regimen. Despite previous reports high mortality with concentrations less than 5 6 g/dL, these illustrate that meticulous care selected severe can lead successful outcomes, without transfusion.
Abstract Serotonin axons in the adult rodent brain can regrow and recover their function following several forms of injury including controlled cortical impact (CCI), a neocortical stab wound, or systemic amphetamine toxicity. To assess whether this capacity for regrowth is unique to serotonergic fibers, we used CCI models fibers from other neuromodulatory systems also injury. Using tyrosine-hydoxylase (TH) immunohistochemistry measured density catecholaminergic before at various time points...
Human cardiac stem cells (hCSCs) are self-renewing, clonogenic and have the ability to differentiate into myocytes, smooth muscle endothelial in vitro vivo. Since Ca 2+ plays a crucial role mechanotransduction activation of signalling pathways mature cells, intracellular cycling was studied hCSCs determine function this cation cell division commitment myocyte lineage. For purpose, were exposed conditions favouring proliferation differentiation affecting homeostasis. Moreover, loaded with...
Background Body mass index (BMI) above the normal range has been associated with poorer treatment outcomes in patients osteochondritis dissecans (OCD) of knee. Patients BMIs over 25kg/m2 show an increased risk postoperative arthritis, and BMI also shown to be independently predictive osteochondral allograft transplantations failure knee OCD. However, these data have largely focused on post-treatment relating Considering increase childhood obesity U.S., there is a dearth research regarding...
Aim: A maximum surgical blood order schedule (MSBOS) was implemented at our institution to optimize preoperative ordering and reduce unnecessary preparation for patients undergoing radical prostatectomy (RP), a common urologic procedure. Materials & methods: We conducted retrospective review of who underwent RP from 2010 2016 categorized by date (pre- or post-MSBOS) compared blood-ordering practices. Results: After MSBOS implementation, orders changed predominantly type cross-match 2...