A5086207696- Concrete and Cement Materials Research
- Pituitary Gland Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Recycled Aggregate Concrete Performance
- Organ Donation and Transplantation
- Adrenal and Paraganglionic Tumors
- Connective tissue disorders research
- Innovations in Concrete and Construction Materials
- Drilling and Well Engineering
- Cancer, Hypoxia, and Metabolism
- Wound Healing and Treatments
- Geotechnical and Geomechanical Engineering
- Pressure Ulcer Prevention and Management
- Clay minerals and soil interactions
- Asphalt Pavement Performance Evaluation
- CO2 Sequestration and Geologic Interactions
- Mesenchymal stem cell research
- Mining and Gasification Technologies
- Mineral Processing and Grinding
- Concrete Properties and Behavior
- Transplantation: Methods and Outcomes
- Building materials and conservation
Georgia Institute of Technology
2021-2024
University of Modena and Reggio Emilia
2020-2023
Azienda Ospedaliero-Universitaria di Modena
2022
Creative Commons
2022
Newcastle University
2018-2021
Sapienza University of Rome
2010-2017
Queen Mary University of London
2008-2013
William Harvey Research Institute
2012
Istituto Superiore di Sanità
2010
Endocrinology Research Center
2009
Context: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene familial isolated pituitary adenomas (FIPA). It is not clear, however, how this molecular chaperone involved tumorigenesis. Objective: AIP sequence changes and expression were studied FIPA sporadic adenomas. The function of normal mutated molecules was on cell proliferation protein-protein interaction. Cellular ultrastructural localization determined cells. Patients: Twenty-six kindreds 85...
IntroductionGhrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite metabolism regulation. The cannabinoid receptor type 1 (CB1) antagonist rimonabant can block orexigenic ghrelin. In study, we have elucidated mechanism putative ghrelin-cannabinoid interaction.MethodsThe effects ghrelin CB1 wild-type mice, CB1-knockout animals, were studied on food intake, AMPK activity...
Chronic exposure to glucocorticoid hormones, resulting from either drug treatment or Cushing's syndrome, results in insulin resistance, central obesity, and symptoms similar the metabolic syndrome. We hypothesized that major effects of corticosteroids are mediated by changes key enzyme adenosine monophosphate-activated protein kinase (AMPK) activity. Activation AMPK is known stimulate appetite hypothalamus catabolic processes periphery. assessed activity expression several enzymes...
Geopolymers are hydrated aluminosilicates with excellent binding properties. appeal to the construction sector as a more sustainable alternative traditional cements, but their exploitation is limited by poor understanding of linkage between chemical composition and macroscopic Molecular simulations can help clarify this linkage, existing models based on amorphous or crystalline aluminosilicate structures provide only partial explanation experimental data nanoscale. This paper presents new...
Features of the metabolic syndrome such as central obesity with insulin resistance and dyslipidemia are typical signs Cushing's common side effects prolonged glucocorticoid treatment. AMP-activated protein kinase (AMPK), a key regulatory enzyme lipid carbohydrate metabolism well appetite, is involved in development deleterious excess glucocorticoids, but no data available humans. In current study, we demonstrate effect high levels on AMPK activity human adipose tissue samples from patients...
This study aimed to investigate whether the growth hormone release and metabolic effects of ghrelin on AMPK activity peripheral tissues are mediated by cannabinoid receptor type 1 (CB1) central nervous system. CB1-knockout (KO) and/or wild-type mice were injected peripherally or intracerebroventricularly with CB1 antagonist rimonabant tissue gene expression (transcription factors SREBP1c, transmembrane protein FAS, enzyme PEPCK, HSL). Growth levels studied both in vivo vitro. Peripherally...
Osteonecrosis of the femoral head (ONFH) is a progressive degenerative disease that ultimately requires total hip replacement. Mesenchymal stromal/stem cells (MSCs), particularly ones isolated from bone marrow (BM), could be promising tools to restore tissue in ONFH. Here, we established rabbit model mimic pathogenic features human ONFH and challenge an autologous MSC-based treatment. ON has been originally induced by synergic combination surgery steroid administration. Autologous BM-MSCs...
Macrophages and adipocytes contribute to release of cytokines resulting in the chronic inflammatory profile metabolic syndrome. The local increase proinflammatory impairs adipogenesis, formation dysfunctional that are unable store handle lipids. altered lipid fluxes in/from affect whole-body metabolism. We investigated role androgens on adipocyte-derived anti-inflammatory during preadipocyte differentiation.Various differentiation methods were used obtain full conversion 3T3-L1 into mature...
We present a case of man with giant cutaneous horn over his frontal region. This has been presented for the size lesion, due to delayed treatment, and illustrate reasons why growth this lesion possible in western country, 21st century. It was solitary, not painful which caused significant aesthetic problems. The diagnosis based on an ultrasonographic study treatment choice surgical excision. is opportunity review literature about horns, talk main causes lesions and, define role specialist...
The resorption rate of autologous fat transfer (AFT) is 40–60% the implanted tissue, requiring new surgical strategies for tissue reconstruction. We previously demonstrated in a rabbit model that AFT may be empowered by adipose-derived mesenchymal stromal/stem cells (AD-MSCs), which improve graft persistence exerting proangiogenic/anti-inflammatory effects. However, their fate after implantation requires more investigation. report xenograft adipose engineering NOD/SCID mice underwent...
The capital investment in the US for construction and maintenance of infrastructure road network is $150 billion/year. Investments OECD countries will likely stabilize, while other face an exponential growth investments infrastructures driven by development metropolitan cities. Continued “business-as-usual” practice portland asphalt cement concrete pavement ignores increasing warning calls identification more sustainable less energy intensive paving materials.
 Alkali activated...
Objective: Systemic sclerosis is characterized by endothelial dysfunction, autoimmunity abnormalities, and fibrosis of the skin internal organs. The pathogenetic mechanisms underlying systemic vasculopathy are still not clarified. A complex cellular extracellular network interactions has been studied, but it currently unclear what drives activation fibroblasts/myofibroblasts matrix deposition. Methods: Using RNA sequencing, aim work was to identify potential functional pathways implied in...
Summary: Due to the spread of coronavirus disease 2019 pandemic, an increasing number ill patients have been admitted intensive care unit requiring mechanical ventilation. Although prone positioning is considered beneficial, long periods in this position may induce important complications, including pressure ulcers high-risk and uncommon body areas. We report five cases ulcer necrosis chin as a consequence ventilation using autologous fat grafting (AFG) secondary technique. A series with...
Sir, As of April 5, 2020, >120,000 cases coronavirus disease 2019 (COVID-19) and 15,362 deaths have been reported in Italy. The median age patients is between 49 56 years.1–3 incubation period this virus has to be 5.2 days,4 although there suggestion that it may as long 14 days. clinical syndrome nonspecific, which makes clinically indistinguishable from other viral respiratory illnesses. Some even asymptomatic.5 Due low specificity, laboratory tests not useful establishing the diagnosis...