A5029507082- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Fish Ecology and Management Studies
- Hydrology and Watershed Management Studies
- Hydrology and Sediment Transport Processes
- Molecular Biology Techniques and Applications
- Bacteriophages and microbial interactions
- Law in Society and Culture
- Protein Degradation and Inhibitors
- Phenomenology and Existential Philosophy
- Philosophical and Theoretical Analysis
- Philosophy, Ethics, and Existentialism
UNC Lineberger Comprehensive Cancer Center
2025
University of North Carolina at Chapel Hill
2022-2024
IBM (United States)
2016
Abstract The human genome contains regulatory elements, such as enhancers, that are often rewired by cancer cells for the activation of genes promote tumorigenesis and resistance to therapy. This is especially true cancers have little or no known driver mutations within protein coding genes, ovarian cancer. Herein, we utilize an integrated set genomic epigenomic datasets identify clinically relevant super-enhancers preferentially amplified in patients. We systematically probe top 86...
Abstract Breast cancer metastasis poses a significant challenge in treatment, underscoring the need to understand molecular mechanisms involved. In this project, we generated resource dataset that includes ATAC-seq and RNA-seq data from ER positive primary breast tumors matched liver lung metastases. We collected samples four patients at diagnosis addition eight autopsy following cancer-related death, allowing us gain insights into driving metastasis. Our research centered on hypothesis...
Enhancers are critical regulatory elements in the genome that help orchestrate spatiotemporal patterns of gene expression during development and normal physiology. In cancer, enhancers often rewired by various genetic epigenetic mechanisms for activation oncogenes lead to initiation progression. A key feature active is production non-coding RNA molecules called enhancer RNAs, whose functions remain unknown but can be used specify de novo. Using a combination eRNA transcription chromatin...
Abstract Horizontal gene transfer (HGT) is a major contributor to bacterial genome evolution, generating phenotypic diversity, driving the expansion of protein families, and facilitating evolution new phenotypes, metabolic pathways, species. Comparative studies gain in bacteria suggest that frequency with which individual genes successfully undergo HGT varies considerably may be associated number protein–protein interactions participates, is, its connectivity. Two nonexclusive hypotheses...
Abstract Horizontal gene transfer (HGT) is a major contributor to bacterial genome evolution, generating phenotypic diversity, driving the expansion of protein families, and facilitating evolution new phenotypes, metabolic pathways, species. Comparative studies gain in bacteria suggest that frequency with which individual genes successfully undergo HGT varies considerably may be associated number protein-protein interactions participates—its connectivity. Two non-exclusive hypotheses have...
Abstract Triple-negative breast cancer (TNBC) is the most therapeutically recalcitrant form of cancer, which due in part to paucity targeted therapies. A systematic analysis regulatory elements that extend beyond protein-coding genes could uncover avenues for therapeutic intervention. To this end, we analyzed mechanisms TNBC-specific transcriptional enhancers together with their noncoding enhancer RNA (eRNA) transcripts. The functions top 30 eRNA-producing super-enhancers were systematically...
<div>Abstract<p>Triple-negative breast cancer (TNBC) is the most therapeutically recalcitrant form of cancer, which due in part to paucity targeted therapies. A systematic analysis regulatory elements that extend beyond protein-coding genes could uncover avenues for therapeutic intervention. To this end, we analyzed mechanisms TNBC-specific transcriptional enhancers together with their noncoding enhancer RNA (eRNA) transcripts. The functions top 30 eRNA-producing super-enhancers...
<p>Single PDF containing all supplementary figures</p>
Groundwater inputs to two major streams along the southern end of Lake George attenuate summer temperatures resulting in deeper lake intrusion depths relative other streams. Between late April and early October, East West Brook baseflow water generally were cooler than by ∼4 °C mid-summer. Historical data for confirmed that trend occurred as far back 1970. As a consequence spring coupled with higher salinity, from these was hypothesized based on density calculations. Warmer entered overflow...
ABSTRACT The human genome contains regulatory elements, such as enhancers, that are often rewired by cancer cells for the activation of genes promote tumorigenesis and resistance to therapy. This is especially true cancers have little or no known driver mutations within protein coding genes, ovarian cancer. Herein, we utilized an integrated set genomic epigenomic datasets identify clinically relevant super-enhancers preferentially amplified in patients. We systematically probed top 86...