A5100351964- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Kruppel-like factors research
- Chronic Kidney Disease and Diabetes
- Lipid metabolism and disorders
- RNA modifications and cancer
Nanjing Medical University
2020-2025
Jiangsu Province Hospital
2020-2025
Sichuan University
2018
Abstract Long noncoding RNAs (lncRNA) are emerging as a novel class of regulators in gene expression associated with tumorigenesis. However, the role lncRNAs papillary thyroid carcinoma (PTC) is poorly understood. Here, we conducted global lncRNA profiling and identified AB074169 (lncAB) significantly downregulated PTC. Decreased lncAB PTC was caused by CpG hypermethylation within its promoter. Functional studies showed that overexpression led to cell-cycle arrest tumor growth inhibition...
Abstract Obesity is considered as a high‐risk susceptibility state for most metabolic disorders and directly related to preadipocyte differentiation or adipogenesis. Long noncoding RNAs (lncRNAs) are the key factors which have regulatory functions on various critical physiological biological processes. PVT1 was identified an oncogenic lncRNA could promote angiogenesis in gastric cancer. However, molecular pathways adipogenesis had not been clarified yet. In current study, purpose identify...
Tubulointerstitial fibrosis (TIF) is a significant determinant in the pathogenesis of chronic kidney disease (CKD) and commonly concurrent with lipid infiltration renal tubules. Nonetheless, precise regulatory mechanism this phenomenon remains incompletely understood. This research sought to uncover involvement underlying KLF9 accumulation lipids linked TIF. As models, TGF-β1 treated HK-2 cells unilateral ureteral obstruction (UUO) mouse model were utilized. Histopathological analysis...