A5083260261- Gut microbiota and health
- Probiotics and Fermented Foods
- Metabolomics and Mass Spectrometry Studies
- Reproductive tract infections research
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Metabolism and Genetic Disorders
- Molecular spectroscopy and chirality
- Pharmaceutical and Antibiotic Environmental Impacts
- Gastrointestinal motility and disorders
- Complementary and Alternative Medicine Studies
- Indigenous Studies and Ecology
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
Imperial College London
2023-2024
King's College London
2021-2022
The intestine is the primary colonisation site for carbapenem-resistant Enterobacteriaceae (CRE) and serves as a reservoir of CRE that cause invasive infections (e.g. bloodstream infections). Broad-spectrum antibiotics disrupt resistance mediated by gut microbiota, promoting expansion within intestine. Here, we show antibiotic-induced reduction microbial populations leads to an enrichment nutrients depletion inhibitory metabolites, which enhances growth. Antibiotics decrease abundance...
ABSTRACT Lactobacilli and Gardnerella vaginalis are key bacteria within the vaginal microbiota, significantly impacting its chemical environment. Accurately reproducing metabolism in vitro is therefore critical understanding how this may contribute to health disease. Complex media such as brain heart infusion (BHI) support growth of a wide variety but not accurately reproduce conditions found vivo leading over- or under-representation important metabolic processes. Here we use 1 H NMR...
Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome, characterized by low levels lactobacilli and overgrowth diverse group bacteria, associated with higher risk variety infections, surgical complications, cancer, preterm birth (PTB). Despite lack consistently applicable etiology, Prevotella spp. are often both BV PTB, Pr. bivia has known symbiotic relationships Peptostreptococcus anaerobius Gardnerella vaginalis. Higher PTB can also be predicted composite metabolites linked to...
While we face an acute threat from antibiotic resistant bacteria and a lack of new classes antibiotic, there are many effective antimicrobials which have limited application due to concerns regarding their toxicity could be more useful if such risks reduced or eliminated. We modified bolalipid antiseptic used in throat lozenges see it made against some the highest-priority less toxic.
ABSTRACT The intestine is the primary colonisation site for carbapenem-resistant Enterobacteriaceae (CRE) and serves as a reservoir of CRE that cause invasive infections (e.g. bloodstream infections). Antibiotics disrupt resistance mediated by gut microbiota, promoting expansion within intestine. We used ex vivo faecal cultures to measure impact antibiotics (that promote intestinal colonisation) on microbiota from healthy human donors. demonstrated decreased abundance commensals (including...
ABSTRACT Antibiotic treatment significantly disrupts the gut microbiome and promotes vancomycin-resistant Enterococcus (VRE) intestinal colonisation. These disruptions lead to intestine acting as a reservoir for VRE that seed difficult-to-treat infections. Patients would benefit from new treatments prevent or treat However, factors drive growth in are poorly understood. We demonstrated multiple antibiotics promote colonisation increased concentration of wide range nutrients decreased...
ABSTRACT Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome, characterised by low levels lacto-bacilli and overgrowth diverse group bacteria, associated with higher risk variety infections, surgical complications, cancer spontaneous preterm birth (PTB). Despite lack consistently applicable aetiology, Prevotella spp. are often both BV PTB P. bivia has known symbiotic relationships Peptostreptococcus anaerobius Gardnerella vaginalis . Higher can also be predicted composite...