A5062886426- Plant Virus Research Studies
- Insect-Plant Interactions and Control
- Lysosomal Storage Disorders Research
- Carbohydrate Chemistry and Synthesis
- Plant Disease Resistance and Genetics
- Plant and Fungal Interactions Research
- Plant Pathogenic Bacteria Studies
- Insect symbiosis and bacterial influences
- Insect Resistance and Genetics
- Glycosylation and Glycoproteins Research
- Nematode management and characterization studies
- Trypanosoma species research and implications
- Transgenic Plants and Applications
- Agricultural pest management studies
- Vector-Borne Animal Diseases
- Agronomic Practices and Intercropping Systems
- Plant Parasitism and Resistance
- Parkinson's Disease Mechanisms and Treatments
- Cocoa and Sweet Potato Agronomy
- Chromosomal and Genetic Variations
- Cellular transport and secretion
- Autism Spectrum Disorder Research
- Genetic Mapping and Diversity in Plants and Animals
- Animal Disease Management and Epidemiology
- Phytoplasmas and Hemiptera pathogens
Sanofi (United States)
2016-2025
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2014-2024
Centre Occitanie-Montpellier
2020-2024
Université de Montpellier
2017-2024
Institut Agro Montpellier
2005-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Institut de Recherche pour le Développement
2001-2024
L'Institut Agro
2022-2024
Plant Health Institute de Montpellier
2020-2023
Centre Hospitalier Universitaire de Montpellier
2022
Bemisia tabaci, an invasive pest that causes crop damage worldwide, is a highly differentiated species complex, divided into biotypes have mainly been defined based on mitochondrial DNA sequences. Although endosymbionts can potentially induce population differentiation, specialization and indirect selection mtDNA, studies largely ignored these influential passengers in B. despite as many seven bacterial identified. Here, we investigate the composition of whole community worldwide populations...
Maize streak virus (MSV; family Geminiviridae, genus Mastrevirus), the causal agent of maize disease, ranks amongst most serious biological threats to food security in subSaharan Africa. Although five distinct MSV strains have been currently described, only one these - MSV-A causes severe disease maize. Due primarily their not being an obvious threat agriculture, very little is known about 'grass-adapted' strains, MSV-B, -C, -D and -E. Since comparing genetic diversities, geographical...
Abstract Disease emergence events regularly result from human activities such as agriculture, which frequently brings large populations of genetically uniform hosts into contact with potential pathogens. Although viruses cause nearly 50% emerging plant diseases, there is little systematic information about virus distribution across agro-ecological interfaces and gaps in understanding diversity nature. Here we applied a novel landscape-scale geometagenomics approach to examine relationships...
Gaucher disease type 1 is characterized by hepatosplenomegaly, anemia, thrombocytopenia, and skeletal disease. A safe, effective oral therapy needed.To determine whether eliglustat, a novel substrate reduction therapy, safely reverses clinical manifestations in untreated adults with 1.Phase 3, randomized, double-blind, placebo-controlled trial conducted at 18 sites 12 countries from November 2009 to July 2012 among eligible patients splenomegaly plus thrombocytopenia and/or anemia. Of 72...
Venglustat is a small-molecule glucosylceramide synthase (GCS) inhibitor designed to reduce the production of (GL-1) and thus expected substantially formation glucosylceramide-based glycosphingolipids. Because its effect on glycosphingolipid formation, GCS inhibition has therapeutic potential across many disorders affecting metabolism. Therefore, venglustat under development for substrate reduction therapy in multiple diseases, including Gaucher disease type 3, Parkinson's associated with...
Abstract Characterization of Parkinson’s disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to curate research populations, the increasing availability data, advances in natural language processing, particularly large models, allow for a more granular comparison populations than previously possible. This study includes two data-derived (RWD) populations. The are Harvard Biomarkers Study (HBS, N = 935), longitudinal...
Abstract Eliglustat, an oral substrate reduction therapy, is a first‐line treatment for adults with Gaucher disease type 1 (GD1) who are poor, intermediate, or extensive CYP2D6 metabolizers (>90% of patients). In the primary analysis Phase 3 ENGAGE trial (NCT00891202), eliglustat 9 months resulted in significant reductions spleen and liver volumes increases hemoglobin concentration platelet count compared placebo. We report 18‐month outcomes patients entered extension period, which all...
During a large scale "non priori" survey in 2010 of South African plant-infecting single stranded DNA viruses, highly divergent geminivirus genome was isolated from wild spurge, Euphorbia caput-medusae. In addition to being infectious E. caput-medusae, the cloned viral also tomato and Nicotiana benthamiana. The virus, named caput-medusae latent virus (EcmLV) due absence infection symptoms displayed by its natural host, caused severe both N. organisation EcmLV is unique amongst geminiviruses...
A founding paradigm in virology is that the spatial unit of viral replication cycle an individual cell. Multipartite viruses have a segmented genome where each segment encapsidated separately. In this situation not recapitulated single virus particle but population. How multipartite manage to efficiently infect cells with all segments, thus whole information, long-standing perhaps deceptive mystery. By localizing and quantifying segments nanovirus host plant tissues we show they rarely...
Abstract Eliglustat is a first‐line oral therapy for adults with Gaucher disease type 1 (GD1) and poor, intermediate or extensive CYP2D6‐metabolizer phenotypes (>90% of patients). We report the final results Phase 2 trial extension (NCT00358150) in previously untreated adult GD1 patients who had splenomegaly thrombocytopenia and/or anemia received 50 100 mg eliglustat tartrate (equivalent to 42 84 eliglustat) twice daily 8 years. In total, 19 26 completed trial. After years eliglustat,...
Acid sphingomyelinase deficiency (ASMD) (also known as Niemann-Pick disease types A and B) is a rare debilitating lysosomal storage disorder. This prospective, multi-center, multinational longitudinal study aimed to characterize the clinical features of chronic forms ASMD burden over time in children adults.Fifty-nine patients (31 males/28 females) ranging age from 7 64 years with A/B B at least two symptoms participated 5 countries. Disease characteristics were assessed baseline, after 1...
Following the first detection of tomato yellow leaf curl virus (TYLCV) from Reunion (700 km east Madagascar) in 1997 and upsurge Bemisia tabaci (Gennadius) on vegetable crops, two genetic types B. were distinguished using RAPD-PCR cytochrome oxidase I (COI) gene sequence comparisons. One type was assigned to biotype B other genetically dissimilar populations described elsewhere named Ms, after Mascarenes Archipelago. This new forms a distinct group that is sister groups, one which member Q...
Eliglustat is an investigational oral substrate reduction therapy for Gaucher disease type 1 (GD1). Its skeletal effects were evaluated by prospective monitoring of bone mineral density (BMD), fractures, marrow infiltration cells, focal lesions, and infarcts during open-label, multi-site, single-arm phase 2 trial (NCT00358150). Institutional review board approval patient informed consent obtained. (50 or 100 mg) was self-administered mouth twice daily; 19 patients completed 4 years...
Cowpea, (Vigna unguiculata L. (Walp)) is an annual tropical grain legume. Often referred to as "poor man's meat", cowpea one of the most important subsistence legumes cultivated in West Africa due high protein content its seeds. However, African production can be seriously constrained by viral diseases that reduce yields. While twelve cowpea-infecting viruses have been reported from Africa, only three these so-far Burkina Faso. Here we use a virion-associated nucleic acids (VANA)-based...
Abstract Gaucher disease type 3 is a chronic neuronopathic disorder with wide-ranging effects, including hepatosplenomegaly, anaemia, thrombocytopenia, skeletal and diverse neurological manifestations. Biallelic mutations in GBA1 reduce lysosomal acid β-glucosidase activity, its substrates, glucosylceramide glucosylsphingosine, accumulate. Enzyme replacement therapy substrate reduction ameliorate systemic features of disease, but no therapies are approved for Venglustat an investigational,...
Maize streak virus (MSV), which causes maize disease (MSD), is one of the most serious biotic threats to African food security. Here, we use whole MSV genomes sampled over 30 years estimate dates key evolutionary events in 500 year association and maize. The substitution rates implied by our analyses agree closely with those estimated previously controlled evolution experiments, them infer date when maize-adapted strain, MSV-A, was generated recombination between two grass-adapted strains....
Three phase 1 studies of eliglustat tartrate (Genz-112638), an oral inhibitor glucosylceramide synthase under development for treating Gaucher disease type (GD1), evaluated the safety, tolerability, and pharmacokinetics in healthy volunteers after escalating single doses (n = 99), multiple 36), food 24). Eliglustat was well tolerated at ≤ 20 mg/kg 200 mg bid, with 50 bid producing plasma concentrations predicted therapeutic range. No serious adverse events occurred. Mild to moderate nausea,...