A5008011970- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Immune cells in cancer
- Sodium Intake and Health
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Migraine and Headache Studies
- Single-cell and spatial transcriptomics
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Digital Mental Health Interventions
- Inflammasome and immune disorders
- Neurological Disease Mechanisms and Treatments
- Privacy, Security, and Data Protection
- Nutritional Studies and Diet
- Mobile Health and mHealth Applications
MIND Research Institute
2021-2024
Weill Cornell Medicine
2021-2024
Cornell University
2021-2024
Barnard College
2018-2021
Columbia University
2018-2021
Background Headache diaries are a mainstay of migraine management. While many commercial smartphone applications (apps) have been developed for people with migraine, little is known about how well these apps protect patient information and whether they secure to use. Objective We sought assess there privacy issues surrounding so that physicians patients could better understand what medical providing the app companies, potential implications companies (and other third parties) might use...
Summary Cerebral ischemia triggers a powerful inflammatory reaction involving both peripheral leukocytes and brain resident cells. Recent evidence indicates that their differentiation into variety of functional phenotypes contributes to tissue injury repair. However, the temporal dynamics diversity post-stroke immune cell subsets remain poorly understood. To address these limitations, we performed longitudinal single-cell transcriptomic study mouse blood obtain composite picture...
Adverse prenatal environment is a risk factor for the development of psychiatric disorders. Although studies have implicated epigenetic mechanisms, little known about how epigenomic changes come and lead to abnormal behaviors in affected individuals. We sought identify transcriptomic signatures induced by proinflammatory gestational ventral dentate gyrus (vDG), hippocampal region linked avoidance threatening contexts, that persist promote anxiety-like behavior mice. Here we show adversity...
ABSTRACT High dietary salt intake has powerful effects on cerebral blood vessels and emerged as a risk factor for stroke cognitive impairment. In mice, high diet (HSD) leads to reduced flow (CBF), tau hyperphosphorylation dysfunction. However, it is still unclear whether the CBF responsible of HSD cognition. Capillary stalling cause reduction impairment in models Alzheimer’s disease diabetes. Therefore, we tested hypothesis that capillary also contributes HSD. Using two-photon imaging, found...
Stress-related psychological dysfunctions show a marked increase during adolescence, yet the mechanisms that mediate these vulnerabilities are unknown. Notably, however, adolescence is associated with changes in hormonal stress reactivity mediated by hypothalamic-pituitary-adrenal (HPA) axis, which might contribute to dysfunctions. Specifically, pre-adolescent animals display prolonged stress-induced HPA responses compared adults. Previous experience stressors further modify reactivity, such...
ABSTRACT Hypertension, a disease afflicting over one billion individuals worldwide, is leading cause of cognitive impairment, the mechanisms which remain poorly understood. In mouse model hypertension, we found that neurovascular and dysfunction depends on IL-17, cytokine elevated in hypertensive individuals. However, neither circulating IL-17 or brain angiotensin signaling could account full for dysfunction. Rather, produced by T-cells dura mater was major culprit reaching cerebrospinal...
Cerebral ischemia triggers a powerful inflammatory reaction involving infiltration of peripheral leukocytes. Neutrophils, the first immune cells entering ischemic brain, contribute to brain injury by limiting tissue perfusion and destabilizing blood-brain barrier. However, recent evidence indicates that neutrophils can also participate repairing process. Nevertheless, dynamics complexity neutrophil subsets are poorly understood. Here, we performed single-cell transcriptomics obtain picture...
Objective: We sought to assess whether there are privacy issues surrounding smartphone apps so that physicians and patients could better understand what information providing the app companies, potential implications of how companies (and other third parties) might use information. Background: The majority adults report using health related mobile applications (apps), up 20% have recommended their patients. Many commercial been developed for people with neurologic conditions. Design/Methods:...