A5090992965- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Liver Disease Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Long-Term Effects of COVID-19
- Hepatocellular Carcinoma Treatment and Prognosis
- Olfactory and Sensory Function Studies
- Nicotinic Acetylcholine Receptors Study
- Heparin-Induced Thrombocytopenia and Thrombosis
- Social Media in Health Education
- Health Literacy and Information Accessibility
- Consumer Attitudes and Food Labeling
- Organ Transplantation Techniques and Outcomes
- Meat and Animal Product Quality
- Nutritional Studies and Diet
- Anorectal Disease Treatments and Outcomes
- Infection Control and Ventilation
- Hepatitis B Virus Studies
- Vagus Nerve Stimulation Research
- Parasitic infections in humans and animals
- Pectus Deformity Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Liver physiology and pathology
Villa Pineta Hospital
2009-2025
University of Naples Federico II
2014
Saiseikai Niigata Daini Hospital
2009
Virginia Mason Medical Center
2009
The successful deployment of safe and effective vaccines against coronavirus disease 2019 (COVID-19) has been crucial in reducing the global burden. Owing to need for vaccination series over time, continuous observational studies are needed estimate COVID-19 vaccine response real-world conditions. In particular, detection, assessment, understanding adverse effects following immunization (AEFI) with a better address strategies. Therefore, this study aimed investigate risk repeated AEFI...
This sero-survey describes the level and time-trend of antibodies elicited by BNT162b2 COVID-19 vaccine up to 6 months. A strong seroconversion was seen at 30-day serology, with persistence anti-SARS-CoV-2 S-RBD IgG through months from vaccination. However, vaccine-induced started decrease second month.
Abstract This study investigated the response to BNT162b2 mRNA COVID-19 vaccine among healthcare workers (HCWs) in an Italian teaching hospital. 444 participants were surveyed with either multiple RT-PCR assays for detection of SARS-CoV-2 nucleic acid nasopharyngeal swabs or serology testing research virus-specific immunoglobulins. Adverse events following immunization (AEFI) reported. Two weeks after first dose anti-SARS-CoV-2 antibodies exceeded reactivity cut-off 82.5% participants. Four...
This longitudinal observational study investigated the risk of breakthrough SARS-CoV-2 infection up to 6 months after a booster dose an mRNA COVID-19 vaccine in infection-naïve vs. previously infected healthcare workers (HCWs), and whether this difference varied over time. A Cox proportional hazard regression model with Aalen's additive analysis was fitted examine association between infections predictor variables. Overall, we observed incidence rate 2.5 cases per 1000 person-days (95%...
The COVID-19 pandemic has been a health emergency with significant impact on the world due to its high infectiousness. disease, primarily identified in lower respiratory tract, develops numerous clinical symptoms affecting multiple organs and displays finding of anosmia. Several authors have investigated pathogenetic mechanisms olfactory disturbances caused by SARS-CoV-2 infection, proposing different hypotheses showing contradictory results. Since uncertainties remain about possible virus...
SARS-CoV-2 pathogenesis has been recently extended to human central nervous system (CNS), in addition nasopharyngeal truck, eye, lung and gut. The recent literature highlights that some spike glycoprotein regions homologous neurotoxin-like peptides might bind nicotinic Acetyl-Choline Receptors (nAChRs). Spike-nAChR interaction can probably cause dysregulation of CNS cholinergic anti-inflammatory pathways uncontrolled immune-response, both associated a severe COVID-19 pathophysiology. Herein,...
Following the approval of COVID-19 vaccination program by EMA and national authorities, an immunization campaign started in Italy with BNT162b2mRNA vaccine, initially focused on healthcare workers. The active was monitored systemic antibody titration continuous surveillance guaranteed antigenic/molecular tests swabs. Cases infection have been recently observed vaccinated Herein we describe outbreak occurring five physicians out 656 workers belonging to a private hospital, referring mild...
Medication errors, such as unnecessary treatment discontinuation during with direct-acting antivirals (DAAs), can lead to imbalances in the benefit-to-risk ratio. This risk is especially high when medication error leads adverse drug reactions (ADRs). However, date, evidence on frequency of this phenomenon scarce. study aims provide better insight into ADRs possibly due errors leading DAA and their preventability.The Italian Pharmacovigilance Network database was used extract individual case...
We read the recent review article by Marta Kopańska et al. [...]
Abstract Background Effective and rapid immunologic response to vaccines is a crucial strategy for the control SARS-CoV-2 pandemic. Here, we present results of an ongoing longitudinal observational study conducted among healthcare workers (HCWs) Pineta Grande Hospital (Castel Volturno, Italy), who were administered two-dose prime-boost mRNA vaccine BNT162b2. Methods Volunteer HCWs underwent either (i) six RT-PCR assay qualitative detection nucleic acid in nasopharyngeal/oropharyngeal swabs;...