A5085189826- Library Collection Development and Digital Resources
- Library Science and Information Literacy
- Library Science and Administration
- Fashion and Cultural Textiles
- Public Health Policies and Education
- Alzheimer's disease research and treatments
- American Constitutional Law and Politics
- American and British Literature Analysis
- Acute Ischemic Stroke Management
- Crafts, Textile, and Design
- Race, History, and American Society
- Dementia and Cognitive Impairment Research
- Management and Marketing Education
- Literature: history, themes, analysis
- Amyotrophic Lateral Sclerosis Research
- Corporate Governance and Law
- Stroke Rehabilitation and Recovery
- Canadian Identity and History
- Cardiac Health and Mental Health
- Museums and Cultural Heritage
- Migration, Health and Trauma
- Cultural Industries and Urban Development
- Human Resource and Talent Management
- Food Security and Health in Diverse Populations
- Lung Cancer Treatments and Mutations
Boston Medical Center
2025
Cedars-Sinai Medical Center
2022-2024
University of Ottawa
2016-2022
The Chicago School
2022
Acadia University
2022
Columbia University Irving Medical Center
2020-2021
Columbia University
2021
Salford Royal NHS Foundation Trust
2013-2020
University of Manchester
2012-2020
Beth Israel Deaconess Medical Center
2017-2020
The identification of a hexanucleotide repeat expansion in the C9ORF72 gene as cause chromosome 9-linked frontotemporal dementia and motor neuron disease offers opportunity for greater understanding relationship between these disorders other clinical forms lobar degeneration.In this study, we screened cohort 398 patients with dementia, progressive non-fluent aphasia, semantic or mixture syndromes mutations gene.Motor was present 55 (14%).We identified 32 mutations, representing 8% cohort.The...
Objective: We aimed to determine the extent which patients with progressive language impairment conform 2011 primary aphasia (PPA) classification and examine clinicopathologic correlations within PPA variants. Methods: Sixty-two consecutive pathologically confirmed dementia who presented clinically were identified. Patients insufficient clinical information excluded. classifications applied anonymized data taken from patients' initial assessment by raters blinded pathologic diagnosis....
Semantic dementia, a circumscribed disorder of semantic knowledge, provides unique model for understanding the neural basis representation. The study addressed areas contention: relative roles left and right temporal lobe, contribution anterior versus posterior cortex status lobes as amodal hub. Naming word comprehension was examined in 41 dementia patients, 31 with left-predominant 10 right-predominant atrophy. In keeping expectation, naming were significantly poorer patients. Structural...
The purpose of this study was to assess the effect bupropion on cytochrome P450 2D6 (CYP2D6) activity. Twenty-one subjects completed repeated-measures in which dextromethorphan (30-mg oral dose) administered smokers at baseline and after 17 days treatment with either sustained-release (150 mg twice daily) or matching placebo. Subjects quit smoking 3 before second administration. To CYP2D6 activity, urinary dextromethorphan/dextrorphan metabolic ratios were calculated an 8-hour urine...
We aimed to assess sensitivity and specificity of the updated criteria for behavioral variant frontotemporal dementia (bvFTD) based on a large autopsy-confirmed cohort patients with dementia.Two hundred thirty-nine consecutive pathologically confirmed patients, clinically assessed in specialist cognitive unit were identified. Patients predominant aphasia, motor disorders, or insufficient clinical information excluded. Frontotemporal Dementia Consensus applied anonymized data taken from...
Abstract An increase in the efficiency of clinical trial conduct has been successfully demonstrated oncology field, by use multi-arm, multi-stage trials allowing evaluation multiple therapeutic candidates simultaneously, and seamless recruitment to phase 3 for those passing an interim signal efficacy. Replicating this complex innovative design diseases such as Parkinson’s disease is appealing, but addition challenges associated with any assessing a single potentially modifying intervention...
Repeat expansions in C9orf72 are a major cause of frontotemporal dementia with amyotrophic lateral sclerosis (FTD-ALS). Not all FTD-ALS patients show expansions. The study examined whether there clinical differences between and without C9orf72. We case notes from consecutive patients, screened for expansions, documented demographic, neurological, behavioural cognitive characteristics. Sixty met the selection criteria, whom 11 showed expanded repeats (C9-positive) 49 did not (C9-negative). A...
<h3>Background</h3> A proportion of patients with behavioural variant frontotemporal dementia (bvFTD) develop amyotrophic lateral sclerosis (ALS). It is currently unknown whether the and cognitive syndrome in bvFTD ALS (ALS-FTD) indistinguishable from that alone. <h3>Methods</h3> retrospective cohort 241 clinical diagnoses (n=185) or ALS-FTD (n=56) was examined respect to behavioural, neuropsychiatric symptoms. Features were rated as present absent based on information recorded interviews...
We aimed to evaluate the co-occurrence of language and behavioural impairment in patients with frontotemporal lobar degeneration (FTLD) spectrum pathology.Eighty-one dementia pathological confirmation FTLD were identified. Anonymized clinical records from patients' first assessment rated for features consensus criteria, primary progressive aphasia (PPA) criteria 1998 criteria.Over 90% pathology exhibited a combination at least one feature. Changes language, particular, commonly accompanied...
Spontaneous spinal cerebrospinal fluid (CSF) leaks cause intracranial hypotension (SIH) and also may infratentorial superficial siderosis (iSS) but the rate of development among different CSF leak types outcome treatment are not known. We determined time interval from SIH onset to iSS treatment.A total 1,589 patients with underwent neuroimaging was detected in 57 (23 men 34 women, mean age = 41.3 years [3.6%]). examined type underlying by various imaging modalities. Percutaneous surgical...
The differentiation of subtypes primary progressive aphasia (PPA) remains challenging. We aimed to identify optimum neuropsychological measures for characterizing PPA, examine the relationship between behavioural change and PPA determine whether characteristic profiles language, working memory, changes occur in PPA. Forty-seven patients with multi-domain Alzheimer's disease (AD) together 19 age-matched controls underwent a large battery memory language tests. found that simple tasks sentence...
Behavioural variant frontotemporal dementia (bvFTD) is characterised by behaviour change and impaired executive skills. There growing evidence that naming difficulties may also be present but the basis for these unclear. A primary semantic deficit has been proposed, although contributions to breakdown are possible. The study aimed improve understanding of disorder in bvFTD through direct comparison with (SD), examination neural correlates. It address current controversies about role anterior...
This study compared changes in measured versus predicted peak aerobic power (V̇O2peak) following cardiovascular rehabilitation (CR). Peak cardiopulmonary exercise testing (CPET) results were to four V̇O2peak estimation methods: the submaximal modified Bruce treadmill, Astrand-Ryhming cycle ergometer, and Chester step tests, Duke Activity Status Index (DASI).Adults with disease (CVD) who completed a 12-week CR program assessed at baseline 12 weeks follow-up. CPET, DASI three subsequent tests...
Objective The precise relationship between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is incompletely understood. association has been described as a continuum, yet data suggest that this may be an oversimplification. Direct comparisons patients who have behavioural variant FTD (bvFTD) with without ALS are rare. This prospective comparative study aimed to determine whether there phenotypic differences in cognition behaviour FTD-ALS bvFTD alone. Methods Patients or...