A5045710005- Click Chemistry and Applications
- Anesthesia and Neurotoxicity Research
- Synthesis and biological activity
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Agricultural and Food Sciences
- Neuroinflammation and Neurodegeneration Mechanisms
- Electron Spin Resonance Studies
- Biochemical Acid Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- Vitamin C and Antioxidants Research
- Pesticide Exposure and Toxicity
- Synthesis and Biological Evaluation
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Nutrition, Genetics, and Disease
- Environmental and biological studies
- Respiratory Support and Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Nosocomial Infections in ICU
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
Universidade Federal de Ouro Preto
2020-2025
In live organisms, there is a balance between the production of reactive oxygen species (ROS) and their neutralization. The increased level these leads to condition called redox imbalance. aim this study was evaluate protective action isobenzofuranones in primary cultures hippocampal neurons subjected To accomplish this, MTT LIVE/DEAD assays were initially performed. pretreated with 1 2, higher number cells when compared that untreated ones. Regarding imbalance, significant increase...
SYNTHESIS OF NOVEL 1,2,3-TRIAZOLES INSPIRED ON THE SRPIN340 AND EVALUATION THEIR EFFECTS HUMAN GLIOBLASTOMA CELL LINE. It is herein described the synthesis of a series thirty novel 1,2,3-triazole1,4-disubstituted compounds inspired on known SRPKs inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide (SRPIN340) and biological evaluation them against human glioblastoma multiforme cell line U87MG. Starting with 1-fluoro2-nitro-4- (trifluoromethyl)benzene (1), substances were...