A5031599364- Circadian rhythm and melatonin
- Dermatology and Skin Diseases
- Dietary Effects on Health
- Health Literacy and Information Accessibility
- Adipose Tissue and Metabolism
- Social Media in Health Education
- Mobile Health and mHealth Applications
- Asthma and respiratory diseases
- Adrenal Hormones and Disorders
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Genomics, phytochemicals, and oxidative stress
- Microbial Metabolic Engineering and Bioproduction
- Genetic and Kidney Cyst Diseases
- Polyamine Metabolism and Applications
- IL-33, ST2, and ILC Pathways
Leipzig University
2018-2023
Humboldt-Universität zu Berlin
2018-2021
Freie Universität Berlin
2018-2021
Charité - Universitätsmedizin Berlin
2018-2021
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019
Background Experts agree that the promotion of (digital) health literacy should be an integral part school curriculum. However, promoting within German system is difficult because education not a mandatory subject in all states. Therefore, experts suggest could addressed as framework for digital and schools developed by Conference on Education Ministries Cultural Affairs (Kultusministerkonferenz). Objective The goal this study was to evaluate newly e-learning course designed improve...
Organisms adapt their metabolism and draw on reserves as a consequence of food deprivation. The central role the liver in starvation response is to coordinate sufficient energy supply for entire organism, which has frequently been investigated. However, knowledge how circadian rhythms impact alter this scarce. Therefore, we investigated influence different timings global hepatic gene expression. Mice (n=3 each) were challenged with 24-hour deprivation started morning or evening, coupled...
Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachidonic 15-lipoxygenating Alox5 mutant instead 5-lipoxygenating wildtype enzyme. These were leukotriene deficient but exhibited elevated linoleic oxygenase activity. Here we characterized polyenoic fatty metabolism these more detail and tested animals three different experimental inflammation models. In autoimmune...
Atopic diseases constitute a major health challenge for industrialized countries, and elevated levels of interleukin 4 (IL-4) frequently characterize these disorders. Previous in vitroanalyses have indicated that IL-4 strongly upregulates the expression IL-4-sensitive genes human monocytes.To explore whether similar alterations may contribute to pathomechanisms atopic vivo we carried out small-scale case-control clinical study (n = 43), which quantified plasma IgE as well selected blood...
Aims: Most mammalian genomes involve several genes encoding for functionally distinct arachidonate lipoxygenase (ALOX isoforms). Proinflammatory leukotrienes are formed via the ALOX5 pathway, but 12/15-lipoxygenating ALOX isoforms have been implicated in biosynthesis of pro-resolving mediators. In vitro mutagenesis triad determinants abolished leukotriene synthesizing activity ALOX5, biological consequences these alterations not studied. To fill this gap, we created Alox5 knock-in mice,...
The circadian rhythm is a decisive regulator for metabolic homeostasis especially in the liver. importance of diurnal control highlighted by increased risk liver diseases, obesity and syndrome due to disturbance rhythms. However, time resolved vivo studies metabolism are rare molecular resolved, kinetic models can be used phenotyping based on proteomic data, enabling linking rhythmicity protein abundances regulation.
<sec> <title>BACKGROUND</title> Experts agree that the promotion of (digital) health literacy should be an integral part school curriculum. However, promoting within German system is difficult because education not a mandatory subject in all states. Therefore, experts suggest could addressed as framework for digital and schools developed by Conference on Education Ministries Cultural Affairs (Kultusministerkonferenz). </sec> <title>OBJECTIVE</title> The goal this study was to evaluate newly...