A5017141752- Reproductive Health and Contraception
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Reproductive tract infections research
- Pregnancy and Medication Impact
- Global Maternal and Child Health
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- HIV Research and Treatment
- Cervical Cancer and HPV Research
- Maternal and Perinatal Health Interventions
- Data-Driven Disease Surveillance
- Influenza Virus Research Studies
- Reproductive System and Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmaceutical industry and healthcare
- Endometriosis Research and Treatment
- HIV, Drug Use, Sexual Risk
- Emergency and Acute Care Studies
- Estrogen and related hormone effects
- 3D Printing in Biomedical Research
- Healthcare Systems and Technology
- Ovarian function and disorders
- Bariatric Surgery and Outcomes
- Sexual function and dysfunction studies
Population Council
2014-2025
Montefiore Medical Center
2023
RELX Group (United States)
2014-2019
Population Council
2015
RELX Group (United Kingdom)
2014
University of Samarra
2013
New York City Department of Health and Mental Hygiene
2011
St. Luke's-Roosevelt Hospital Center
2009
BackgroundNo empirical data support the 54-58mm external diameter of intravaginal rings (rings) currently available and in development for contraception other indications. Understanding how affects preference, adherence, acceptability is critical optimizing future product development.ObjectivesOur primary objectives were to determine which three non-medicated differing diameters was preferred yielded highest adherence. Secondary comparing acceptability, patterns safety rings.Study DesignIn...
A ring-shaped, contraceptive vaginal system designed to last 1 year (13 cycles) delivers an average of 0·15 mg segesterone acetate and 0·013 ethinylestradiol per day. We evaluated the efficacy this return menses or pregnancy after use.In two identically designed, multicentre, open-label, single-arm, phase 3 trials (one at 15 US academic community sites one 12 international sites), participants followed a 21-days-in, 7-days-out schedule for up 13 cycles. Participants were healthy, sexually...
HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) a non-ARV lectin with potent anti-HIV activity. GRFT’s preclinical safety, lack of systemic absorption after vaginal administration in animal studies, and cross-resistance existing ARV drugs prompted its development for topical PrEP. We investigated pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity PC-6500 (0.1% GRFT carrageenan (CG) gel) healthy women...
Women need multipurpose prevention technologies (MPTs) to simultaneously prevent sexually transmitted infections (STIs), including HIV, with or without contraception. User feedback early in product development is critical for maximizing uptake and continuation. Our global online survey (April 2017-December 2018) explored women's opinions about MPT formulations (e.g., fast-dissolving vaginal inserts, films, intravaginal rings, injectables, implants), preferences long-acting "on-demand"...
Objective: To evaluate the safety and pharmacokinetics of MIV-150 zinc acetate in a carrageenan gel (PC-1005). Acceptability, adherence, pharmacodynamics were also explored. Design: A 3-day open-label run-in (n = 5) preceded placebo-controlled, double-blind trial healthy, HIV-negative, abstinent women randomized (4:1) to vaginally apply 4 mL PC-1005 or placebo once daily for 14 days. Methods: Assessments included physical examinations, labs, colposcopy, biopsies, cervicovaginal lavages...
Expanding contraceptive options could better meet users' diverse needs and preferences. Annovera ® is a vaginal ring that provides year of pregnancy prevention while remaining under user control allowing for regular menstrual cycles. This method may also help to reduce burdens on some health care supply chain systems. However, knowledge gaps exist regarding initial ongoing acceptability rings in African settings. We will undertake an open-label, non-randomized, two-arm, parallel clinical...
ABSTRACT Objective Intravaginal rings (IVRs) are marketed or in development for contraception and other indications. We sought to develop validate the IVR Acceptability Scale (IVR‐AS) as a multidimensional, standardized tool assessing acceptability among end‐users United States. Methods items reflect specific aspects of women male partners. Response options range from 1 (not‐at‐all acceptable) 5 (highly acceptable). evaluated IVR‐AS within randomized, crossover clinical trial three...
Abstract We compared emergency department and ambulatory care syndromic surveillance systems during the pandemic (H1N1) 2009 outbreak in New York City. Emergency departments likely experienced increases influenza-like-illness significantly earlier than facilities because more patients sought at departments, differences case definitions existed, or a combination thereof.
Increased electronic prescribing (eRx) rates have the potential to prevent errors, increase patient safety, and curtail fraud. US Federal meaningful use guidelines require at least a 40% rate.We evaluated eRx among primary care providers in New York City order determine trends as well identify any obstacles increased required by guidelines.The data we analysed included automatic transmissions from enrolled Primary Care Information Project (PCIP) 1 January 2009 July 2010 follow-up telephone...
A randomized, placebo-controlled, efficacy trial of Carraguard was unable to demonstrate a reduction in women's risk HIV infection, which may have been due, part, low adherence (gel used 42 % vaginal sex acts, on average). secondary analysis undertaken understand baseline factors associated with high ≥85 acts). Women who reported ≥1 act, returned opened applicator, and had conclusive post-enrollment test (N = 5990) were included. Adherence estimated as the ratio average weekly applicator...
In Brief Context: During the onset of 2009 pandemic influenza A (H1N1) (pH1N1), New York City Department Health and Mental Hygiene implemented a pilot respiratory virus surveillance system. Objectives: We evaluated performance this system, which linked electronic health record (EHR) clinical, epidemiologic, diagnostic data to monitor influenza-like illness (ILI) in community. Design: Surveillance was conducted at 9 community centers with EHRs. Clinical decision support system alerts...
To predict serum segesterone (SA) and ethinyl estradiol (EE) levels after 364 days of hypothetical continuous use (without removal) a cyclic contraceptive vaginal system (CVS) containing 0.15 mg SA 0.013 EE.We used pharmacokinetic (PK) data (n = 37) from multicenter, open-label, nonrandomized study healthy women (18-38 years) that the CVS for 13 cycles in 21 days-in/7 days-out regimen to develop linear regression model daily EE use. We then determined residual SA/EE vitro 18 randomly chosen...
Abstract To identify biomarkers of hormonal contraceptive (HC) use in urine and saliva, we conducted a pilot study with 30 women initiating levonorgestrel (LNG) containing combined oral contraceptives (COCs) or depot medroxyprogesterone acetate (DMPA) (15/group). Based on established COC pharmacokinetics, collected serum samples before ingestion during Days one three use, DMPA injection 21 60 post-injection. We used liquid chromatography-tandem mass spectrometry (LC–MS/MS) to measure...
The search for alternative naturally occurring antimicrobial agents will always continue, especially when emerging diseases like COVID-19 provide an urgency to identify and develop safe effective ways prevent or treat these infections. purpose of this study was evaluate the potential activity as well antioxidant properties commercial samples from four traditional medicinal plants used in Central America: