A5050985167- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Lung Cancer Treatments and Mutations
- Congenital Heart Disease Studies
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Atrial Fibrillation Management and Outcomes
- Cancer Genomics and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Patient-Provider Communication in Healthcare
- Lung Cancer Research Studies
- Nutrition and Health in Aging
- Cancer-related gene regulation
- Cardiac tumors and thrombi
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
University Health Network
2016-2025
Princess Margaret Cancer Centre
2020-2025
Toronto General Hospital
2016-2024
University of Toronto
2019-2024
Health Net
2022
Johannes Gutenberg University Mainz
2014
This study reviewed a series of patients treated with transcatheter closure septal defect to treat platypnea-orthodeoxia syndrome, specific attention characteristics and device choice. Platypnea–orthodeoxia syndrome is an uncommon condition characterized by positional dyspnea hypoxemia due intracardiac right-to-left shunting through patent foramen ovale (PFO), atrial defect, or pulmonary arteriovenous malformations. Percutaneous such defects the treatment In this single-center series, 52...
Abstract Background Brain metastasis (BrM) and Leptomeningeal Carcinomatosis (LMC) are uncommon complications in gastroesophageal carcinoma (GEC) patients. These patients have a poor prognosis challenging to treat. We described the clinicopathologic features outcomes largest cohort of Central Nervous System (CNS) GEC Methods single-center retrospective study treated from 2007 2021. Clinicopathologic characteristics treatment modalities were reviewed. Survival was calculated date CNS...
493 Background: Metastatic gastroesophageal adenocarcinoma (GEA) is a heterogeneous disease with an overall poor prognosis. The tumour microenvironment (TME) between the primary and metastatic compartment not well characterized. This study aims to describe immunogenomic features of matched GEA their correlation clinical outcomes. Methods: We performed whole exome sequencing (WES, n=36) total RNA (RNA-seq, on prospectively collected cohort GEA, which 14 had tissues. used TME deconvolution...
371 Background: The therapeutic approach in locally advanced GEC is evolving. NA-CRT followed by surgery has been recommended based on the CROSS trial. SANO trial reports active surveillance may be an alternative clinically complete response after D-CRT both squamous cell carcinoma (SCC) and adenocarcinoma (AC). SCC AC are different diseases with differences tumor location, etiology, biology. Despite evolving landscape, there still a role for approaches. In our large observational cohort...
Human epidermal growth factor receptor 2 (HER2) overexpression is present in approximately 20-25 of patients with advanced gastroesophageal adenocarcinoma (GEA). Upon progression on 1st line therapy, ramucirumab and paclitaxel (rampac) given ≥2 setting regardless HER2 status. We aim to assess whether associated better survival positive(+) pts compared those HER2(-) disease. reviewed all consecutive adult metastatic/unresectable GEA who were treated rampac for ≥2nd therapy at Princess...
Abstract Background: Although GEC is most common in the elderly population, there a rising incidence of YO defined as occurring patients ≤50 years age. The clinical and genomic differences between older onset disease remain unclear. We aim to comprehensively explore landscape compare with (>50 years) elucidate potential molecular two age groups that may guide therapeutic approaches future. Methods: Data from Association for Cancer Research Project Genomics Evidence Neoplasia...
ABSTRACT Background The majority of esophageal and gastric cancers are diagnosed at an advanced stage with poor overall survival (OS). Whether the pre‐diagnostic interval from symptom onset has any impact on OS is unclear. We investigated this question in peri‐COVID19 pandemic era. Methods retrospectively analyzed a cohort 308 patients esophageal, gastroesophageal junction, or carcinoma treated curative intent Princess Margaret Cancer Centre January 2017 to December 2021. Clinical details...
Abstract Background Malnutrition and sarcopenia are poor prognostic factors in many cancers. Studies gastric esophageal (GE) cancer have focused on curative intent patients. This study aims to evaluate the utility of malnutrition de novo metastatic GE adenocarcinoma. Methods Patients with adenocarcinoma seen at Princess Margaret Cancer Centre from 2010 2016 an available pre‐treatment abdominal computed tomography (CT) were included. was defined as nutritional risk index (NRI) <97.5....
Coronary artery fistulae (CAF) are rare congenital cardiac abnormalities. With increasing age, patients with moderate to large likely become symptomatic and encounter complications. Percutaneous closure has been accepted as a safe effective alternative surgery; however, information regarding long-term outcomes in adult after transcatheter is limited.We describe our 20-year experience percutaneous of CAF patients, focusing on outcomes.From 1995 2015, 25 underwent 33 interventions close 26 at...
Abstract Background Prognostic scores that can identify patients at risk for early death are needed to aid treatment decision-making and patient selection clinical trials. We compared the accuracy of four predict (within 90 days) overall survival (OS) in with metastatic gastric esophageal (GE) cancer. Methods Advanced GE cancer receiving first-line systemic therapy were included. risks calculated using: Royal Marsden Hospital (RMH), MD Anderson Cancer Centre (MDACC), Gustave Roussy Immune...
Metastatic gastroesophageal adenocarcinoma (GEA) is a heterogeneous disease with an overall poor prognosis. The impact of sites metastatic dissemination on survival not well characterized. This study aimed to evaluate whether certain impacts survival.A retrospective analysis 375 patients GEA treated at the Princess Margaret Cancer Centre from 2006 2016 was performed. Overall (OS) and progression-free (PFS) were estimated using Kaplan-Meier method. Cox proportional hazards regression models...
Abstract Background An especially significant event in the patient–oncologist relationship is initial consultation, where many complex topics—diagnosis, treatment intent, and often, prognosis—are discussed a relatively short period of time. This study aimed to measure patients' understanding information during their first medical oncology visit satisfaction with communication from oncologists. Methods Between January August 2021, patients without prior systemic gastrointestinal malignancy...
Objectives To identify combined clinical, radiomic, and delta-radiomic features in metastatic gastroesophageal adenocarcinomas (GEAs) that may predict survival outcomes. Methods A total of 166 patients with GEAs on palliative chemotherapy baseline treatment/follow-up (8–12 weeks) contrast-enhanced CT were retrospectively identified. Demographic clinical data collected. Three-dimensional whole-lesional radiomic analysis was performed the scans. “Delta” calculated based change parameters...
282 Background: Outcomes remain poor for patients with metastatic gastric, gastroesophageal and esophageal adenocarcinoma (GEAC) median survival of 14 months combination chemotherapy immunotherapy as per the Checkmate 649 trial. There is limited data to clarify if any differences exist between denovo recurrent GEAC in terms response systemic therapy. We compare baseline characteristics outcomes our cohort. Methods: A retrospective observational analysis was conducted include reviewed at...
Abstract Background Patient-reported outcomes measures (PROM) are self-reflections of an individual’s physical functioning and emotional well-being. The Edmonton Symptom Assessment Scale (ESAS) is a simple validated PRO tool 10 common symptoms patient-reported functional status (PRFS) measure. prognostic value this unknown in patients with gastroesophageal cancer (GEC). In study, we examined the association between ESAS score overall survival (OS) GEC, prognostication difference Eastern...
Abstract Background The incidence of esophageal and gastric carcinoma (GEC) in elderly patients is increasing, yet ≥75 years have historically been underrepresented clinical trials. We sought to investigate palliative chemotherapy administration patterns survival outcomes older adults. Materials Methods A retrospective analysis identified aged 65-74 (young-old) (older-old) diagnosed with advanced GEC. Patient tumor characteristics were recorded, descriptive analysis, time-to-event data using...
Abstract Background The absence of recurrent mutations in esophageal adenocarcinoma (EAC) poses a challenge detecting circulating tumor DNA (ctDNA) plasma and may hinder the advancement liquid biopsy methods. To address this, we cultured patient-derived EAC organoids (PDOs), speculating that they could serve as guide for identifying ctDNA patient's blood samples. This approach aims to leverage potential tool overcome complexity EAC, offering promising avenue refining strategies clinical...
Abstract Background Esophageal adenocarcinoma tumors are divided into three grades based on the tumour’s histological differentiation: well, moderate and poor. Poorly differentiated tumours have a worse survival rate than well tumours. Understanding molecular programs of this differentiation may lead to identification novel therapeutic interventions specific tumour differentiation. We utilized laser-capture microdissection enrich cells followed by gene expression profiling (RNA-seq) identify...
The following essay studies the strategies and practices applied by Indonesian domestic workers in Singapore order to accumulate money. This is done presenting background situation, especially regarding female labor migration from Indonesia other countries, examining specific income conditions experienced Singapore. particular focus of this on gaining a deeper understanding how women act within restrictive framework, i.e. identifying their legal illegal for increasing regular “negative”...