A5061506468- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Folate and B Vitamins Research
- Cardiac Arrest and Resuscitation
- Esophageal and GI Pathology
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Vascular Procedures and Complications
- Ultrasound in Clinical Applications
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Coronary Artery Anomalies
- Cardiac Health and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac tumors and thrombi
- Renal and Vascular Pathologies
- Thermal Regulation in Medicine
Case Western Reserve University
2016-2025
Mount Sinai Hospital
1998-2025
University Hospitals of Cleveland
2017-2023
University School
2022
St. Vincent Charity Hospital
2016-2017
Aurora St. Luke's Medical Center
2000-2016
Nia Association
2015
Creative Commons
2015
Aurora Health Care
2015
University of Wisconsin–Madison
2011-2015
Retrospective and case-control studies show that hyperhomocysteinemia is an independent risk factor for atherosclerosis in patients with end-stage renal disease. We studied prospectively the association between total homocysteine cardiovascular outcomes.In all, 167 (93 men, 74 women; mean age, 56.3+/-14.7 years) were followed a duration of 17.4+/-6.4 months. Cardiovascular events causes mortality related to values other factors. Cox regression analysis was used identify predictors mortality....
Background High plasma homocysteine is associated with premature coronary artery disease in men, but the threshold concentration defining this risk and its importance women elderly are unknown. Furthermore, although low B vitamin status increases homocysteine, link between these vitamins unclear. Methods Results We compared 304 patients 231 control subjects. Risk factors concentrations of folate, B12, pyridoxal 5′-phosphate were documented. A 14 μmol/L conferred an odds ratio 4.8 ( P...
A high level of total plasma homocysteine is a risk factor for atherosclerosis, which an important cause death in renal failure. We evaluated the role this as vascular complications end-stage disease.Total fasting and other factors were documented 176 dialysis patients (97 men, 79 women; mean age, 56.3 +/- 14.8 years). Folate, vitamin B12, pyridoxal phosphate concentrations also determined. The prevalence values was determined by comparison with normal reference population, associated...
Abstract The objective of this study was to compare the efficacy N‐acetylcysteine (NAC), fenoldopam, and saline in preventing radiocontrast‐induced nephropathy (RCIN) high‐risk patients undergoing cardiovascular procedures. We prospectively enrolled 123 who were scheduled for procedures had a baseline creatinine > 1.6 mg/dl or clearance < 60 ml/min. Patients randomly assigned receive either (0.45% normal at 1 cc/kg) 12 hr before after procedure, fenoldopam (0.1 μg/kg/min) plus 4 prior...
While randomized clinical trials have compared clopidogrel with higher potency adenosine diphosphate (ADP) receptor inhibitors among patients acute myocardial infarction, little is known about the frequency, effectiveness and safety of switching between ADP in routine practice. We studied 11,999 infarction treated percutaneous coronary intervention at 230 hospitals from April 2010 to October 2012 TRANSLATE-ACS study. Multivariable Cox regression was used compare six-month post-discharge...
A high plasma homocysteine concentration is a risk factor for atherosclerosis and thrombosis, which are major causes of morbidity mortality in heart transplant patients. High concentrations may be caused by lower folate vitamin B6 levels. We hypothesized that these patients might have low levels B6, could contribute to the development vascular complications.Total fasting was measured 189 cardiac recipients healthy controls, as were folate, B12, creatinine.Homocysteine higher than controls...
Abstract Background Autologous hematopoietic stem cell transplant (HSCT) emerged as a treatment for refractory CD after several clinical studies including randomized trial (ASTIC).1,2 In patients at risk bowel failure these demonstrated an endoscopic response in over 80% of with two related deaths. A recent using alternative fludarabine-based conditioning regimen had unexpected safety outcomes 2 deaths and renal secondary to thrombotic microangiopathy.3 Here we report long-term HSCT...
Introduction: Ischemic heart disease (IHD) remains a leading cause of death globally, with its impact disproportionately higher in underserved regions, where access to specialist care is limited. In rural areas like Portage County, Ohio, geographic isolation and lack local healthcare options have led delayed treatment poor outcomes. 2016, catheterization (cath) lab, alongside comprehensive cardiovascular screening prevention programs, was established address the issue. Hypothesis: We...
Carotid angioplasty and stenting to treat extracranial carotid stenosis is an alternative (as yet not widely accepted) high-risk surgery, but its safety efficacy are little known, especially in elderly patients. We reviewed our 3-year experience of treating 100 patients (> 65 years old) considered be inoperable (76 men, 24 women, mean age 76 ± 10 years, follow-up 18 9.2 months) present two case histories. Most (85%) were symptomatic (transient ischemic attacks 60, stroke 25); 80 had...
Abstract Patients who suffer cardiogenic shock after cardiac arrest have a very poor prognosis. Left ventricular assist devices proven to be useful in these patients improve survival. Recently introduced percutaneous are easier use and can inserted quickly the catheterization laboratory. We describe case where intra‐aortic balloon pump by itself was not enough provide hemodynamic support patient with arrest. The Impella Recover ® LP 2.5 system (ABIOMED, Inc., Danvers, MA) successfully used...
Endovascular intervention deploying a kissing stents (KS) technique has been used as an alternative to surgical in treating symptomatic aortoiliac occlusive disease. However, the long-term results on high-risk patients are unknown. We retrospectively analyzed data who underwent endovascular using KS at our institution. Fifty aged 62 +/- 6.4 years with severe stenosis stent-supported angioplasty technique. Thirty percent of had total occlusion distal aorta and/or iliac arteries. Twelve...
Primary percutaneous coronary intervention (PPCI) is the choice reperfusion strategy for acute ST-segment elevation myocardial infarction (STEMI). However, data on PPCI in elderly patients are sparse. This study determined clinical outcome post-PPCI versus younger with STEMI. A cohort of 790 consecutive STEMI was studied survival and major adverse cardiovascular events (MACE) after using a precise cardiac catheterization protocol. Patients were divided into two groups: those ≥75 years...
Abstract Background: Cardiac allograft vasculopathy (CAV) is the leading cause of death after first year following heart transplantation. We compared restenosis rates, mortality, and other major adverse cardiac events (MACE) between transplant recipients treated with DES BMS for CAV. Methods: All patients from our registry undergoing PCI stenting CAV were identified. Procedural data, baseline clinical characteristics, yearly coronary angiography, prospectively collected. Primary outcome was...