A5084721186- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Graphene and Nanomaterials Applications
- Adipokines, Inflammation, and Metabolic Diseases
- ATP Synthase and ATPases Research
- Diet and metabolism studies
- Viral Infections and Immunology Research
- Nanoparticle-Based Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Tissue Engineering and Regenerative Medicine
- Fatty Acid Research and Health
- SARS-CoV-2 and COVID-19 Research
- Nanoparticles: synthesis and applications
- Signaling Pathways in Disease
- Cannabis and Cannabinoid Research
- Cancer Immunotherapy and Biomarkers
- Heart Failure Treatment and Management
- Metabolism and Genetic Disorders
- Vitamin D Research Studies
- Heavy Metal Exposure and Toxicity
Tecnológico de Monterrey
2016-2025
Hospital Zambrano Hellion
2016-2025
Medicina
2014-2015
Houston Methodist
2009
Temple University
2008
Instituto Nacional de Cardiología
2003-2006
Abstract The inappropriate use of antibiotics and the inadequate control infections have led to emergence drug-resistant strains. In recent years, metallo-pharmaceutics metallic nanoparticles been proposed as potential alternative antimicrobials due their broad-spectrum antimicrobial properties. Moreover, findings shown that combinations transition metal compounds can exhibit synergistic Therefore, synthesis design bimetallic is a field worth exploring harness interactions between groups...
The mitochondrial permeability transition pore (mPTP), an energy-dissipating channel activated by calcium, contributes to reperfusion damage depolarizing the inner membrane potential. As Ca(2+) overload is a main inductor of mPTP opening, we examined effect Ru(360), selective inhibitor calcium uptake system against myocardial induced in rat model.Myocardial injury was 5-min occlusion left anterior descending coronary artery, followed anaesthetized open-chest rats. We measured...
Vitamin D deficiency is highly prevalent worldwide. It has been associated with heart failure (HF) given its immunoregulatory functions. In-vitro and animal models have shown protective roles through mechanisms involving procollagen-1, JNK2, calcineurin/NFAT, NF-κB, MAPK, Th1, Th2, Th17, cytokines, cholesterol-efflux, oxLDL, GLUT4, among others. A 12-month follow-up in HF patients showed a high prevalence of vitamin deficiency, no seasonal variation (64.7-82.4%). positive correlation between...
Due to the emergence of multi-drug resistant strains, development novel antibiotics has become a critical issue. One promising approach is use transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback metals their toxicity eukaryotic Here, we show that barriers them as therapeutic agents could be mitigated by combining with silver. We demonstrate synergism combinatorial treatments (Silver/transition...
The role of the mitochondrial calcium uniporter (MCU) in energy dysfunction and hypertrophy heart failure (HF) remains unknown. In angiotensin II (ANGII)–induced hypertrophic cardiac cells we have shown that overexpress MCU present bioenergetic dysfunction. However, by silencing MCU, cell are prevented blocking overload, increase reactive oxygen species, activation nuclear factor kappa B–dependent proinflammatory signaling. Moreover, identified a calcium/calmodulin–independent protein kinase...
Stress-induced cardiomyopathy, triggered by acute catecholamine discharge, is a syndrome characterized transient, apical ballooning linked to heart failure and ventricular arrhythmias. Rats receiving an isoproterenol (ISO) overdose (OV) suffer cardiac apex ischemia-reperfusion damage arrhythmia, then undergo remodeling dysfunction. Nevertheless, the subcellular mechanisms underlying dysfunction after subsides are not thoroughly understood. To address this question, Wistar rats received...
The effective delivery of antioxidants to the cells is hindered by their high metabolization rate. In this work, quercetin was encapsulated in poly(lactic-co-glycolic) acid (PLGA) nanoparticles. They were characterized terms its physicochemical properties (particle size distribution, ζ -potential, encapsulation efficiency, release and biological interactions with cardiac regarding nanoparticle association, internalization protective capability against relevant challenges). A better achieved...
Cyclophilin D (CypD) mediates the mitochondrial permeability transition pore (mPTP) opening that contributes to dysfunction. CypD is regulated by its acetylation/deacetylation state depends on Sirtuin-3 (SIRT3) deacetylase. Since obesity and metabolic syndrome decrease SIRT3 activity expression, we tested hypothesis hyperacetylation promotes dysfunction under this pathophysiological state, which associated with ventricular heart failure.Myocardial tissue samples from patients left failure,...
Abstract Bariatric and metabolic surgery has shown to promote weight loss reduce systemic inflammation. However, the sequence timing of events regarding improvement inflammation resolution been rarely explored. Furthermore, data on inflammatory markers Th17 Th1 cell responses after bariatric is scarce. We conducted a prospective study in subjects with obesity that underwent surgery, follow-ups at 3 6 months. Anthropometric such as insulin levels, HOMA-IR, lipid parameters declined...
Abstract Background Childhood obesity is a serious public health concern that confers greater risk of developing important comorbidities such as MetS and T2DM. Recent studies evidence gut microbiota may be contributing factor; however, only few exist in school-age children. Understanding the potential role T2DM pathophysiology from early stages life might contribute to innovative microbiome-based interventions improve health. The main objective present study was characterize compare bacteria...
Mitochondrial calcium overload has been implicated in the irreversible damage of reperfused heart. Accordingly, we studied effect an oxygen-bridged dinuclear ruthenium amine complex (Ru360), which is a selective and potent mitochondrial uniporter blocker, on dysfunction matrix free-calcium concentration mitochondria isolated from rat hearts. The perfusion Ru360 maintained oxidative phosphorylation prevented opening permeability transition pore We found that only partially inhibited...
The sympathetic nervous system is a critical regulator of cardiac function (heart rate and contractility) in health disease. Sympathetic agonists bind to adrenergic receptors that are known activate protein kinase A, which phosphorylates target proteins enhances performance. Recently, it has been proposed A-mediated phosphorylation the ryanodine receptor (the Ca(2+) release channel sarcoplasmic reticulum at single residue, Ser2808) component regulation function. This highly controversial...
Recent evidence has shown that nanoparticles have been used to improve or create new functional properties for common products may pose potential risks human health. Silicon dioxide (SiO2) emerged as a promising therapy vector the heart. However, its toxicity and mechanisms of damage remain poorly understood. This study provides first exploration SiO2-induced in cultured cardiomyocytes exposed 7- 670-nm SiO2 particles. We evaluated mechanism cell death isolated adult 24-h incubation. The...
Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin production the skin and associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, inflammatory markers according to seasonal variation Mexican healthy older adults. The same cohort was followed during 12 months. deficiency/insufficiency found 91.3% of subjects despite living appropriate latitude (25°40'0″N). 25(OH)D levels remained below <30...
Abstract Bacterial species are able to colonize and establish communities in biotic abiotic surfaces. Moreover, within the past five decades, incidence of bacterial strains resistant currently used antibiotics has increased dramatically. This led diverse health issues economical losses for different industries. Therefore, there is a latent need develop new more efficient antimicrobials. work reports an production exopolysaccharide native yeast strain isolated from Mexican Northeast,...
Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related abnormal calcium handling and energetic failure cardiomyocytes. Moreover, precise mechanisms underlying this debacle remain unclear. In order elucidate these mechanisms, article explores ex vivo function mitochondria after exposure nanoSiO2.The cumulative...