A5012387791- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Advanced Proteomics Techniques and Applications
- Fish Ecology and Management Studies
- PARP inhibition in cancer therapy
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- Zebrafish Biomedical Research Applications
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- Cell Image Analysis Techniques
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Physiological and biochemical adaptations
- Marine and fisheries research
- Avian ecology and behavior
- Gene expression and cancer classification
- Nitric Oxide and Endothelin Effects
Institute of Cancer Research
2022-2025
Institute of Cancer Research
2024
Technische Universität Dresden
2022
Universität Innsbruck
2018-2019
Reactive oxygen species (ROS) at the right concentration promote cell proliferation in culture, stem cells, and model organisms. However, mystery of how ROS signaling is coordinated with cycle progression integrated into control machinery on molecular level remains unsolved. Here, we report increasing levels mitochondrial during human lines that target cyclin-dependent kinase 2 (CDK2). Chemical metabolic interferences production decrease T-loop phosphorylation CDK2 so impede its full...
The cell cycle governs a precise series of molecular events, regulated by coordinated changes in protein and phosphorylation abundance, that culminates the generation two daughter cells. Here, we present proteomic phosphoproteomic analysis human hTERT-RPE-1 cells using deep quantitative mass spectrometry isobaric labelling. By analysing non-transformed improving temporal resolution coverage key regulators, dataset cycle-dependent site oscillation offers foundational reference for...
SUMMARY Cells are constantly exposed to reactive oxygen species (ROS) from both intrinsic and extrinsic sources. ROS influence proliferation cell fate through cysteine oxidation (S-sulfenylation), but specific targets mechanisms remain unclear. Here, we use redox proteomics identify cycle-coordinated S-sulfenylation investigate its role in cycle decision-making. We find that of a single (C41) on the CDK inhibitor p21 during G2 phase determines whether cells continue proliferate. Preventing...
Piscivorous birds frequently display sex-specific differences in their hunting and feeding behavior, which lead to diverging impacts on prey populations. Cormorants (Phalacrocoracidae), for example, were previously studied examine dietary between the sexes males found consume larger fish coastal areas during autumn winter. However, information partitioning breeding generally foraging inland waters is missing. Here, we assess choice of Great (Phalacrocorax carbo) two subsequent seasons...
Abstract The cell cycle governs a precise series of molecular events, regulated by coordinated changes in protein and phosphorylation abundance, that culminates the generation two daughter cells. Here, we present proteomic phosphoproteomic analysis human hTERT-RPE-1 cells using deep quantitative mass spectrometry isobaric labelling. Through analysing non-transformed cells, improving temporal resolution coverage key regulators, dataset cycle-dependent site oscillation offers foundational...
Abstract Mitotic DNA double-strand breaks (DSBs) accumulate in response to replication stress or BRCA1/2 deficiency posing a significant threat genome stability as repair by non-homologous end-joining (NHEJ) and homologous recombination (HR) is inactivated mitosis. cells instead rely on the mechanisms of microhomology mediated (MMEJ) mitotic synthesis (MiDAS). However, how these pathways are regulated mitosis remains unknown. Here we reveal CIP2A-TOPBP1 complex facilitates recruitment SMX...
SUMMARY Long considered as cytotoxic reagents, reactive oxygen species (ROS) at the right concentration promote cell proliferation in culture, stem cells and model organisms. However, how ROS signaling is coordinated with cycle progression integrated into control machinery on molecular level remains unsolved. Here, we report oscillations of mitochondrial during that target cyclin-dependent kinase 2 (CDK2). Chemical metabolic interference production decrease T-loop phosphorylation CDK2,...