A5013488169- Melanoma and MAPK Pathways
- Synthesis of Tetrazole Derivatives
- Beetle Biology and Toxicology Studies
- Quinazolinone synthesis and applications
- Protein Degradation and Inhibitors
- Cutaneous Melanoma Detection and Management
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- Electrospun Nanofibers in Biomedical Applications
- Cellular Mechanics and Interactions
- Microbial Metabolic Engineering and Bioproduction
- Cancer, Hypoxia, and Metabolism
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Nanoplatforms for cancer theranostics
University of Michigan
2020-2024
University of Virginia
2022-2024
Samueli Institute
2022
University of California, Los Angeles
2022
Abstract Neurofibromin 1 (NF1) loss of function (LoF) mutations are frequent in melanoma and drive hyperactivated RAS tumor growth. NF1LoF cells, however, do not show consistent sensitivity to individual MEK, ERK, or PI3K/mTOR inhibitors. To identify more effective therapeutic strategies for treating melanoma, we performed a targeted kinase inhibitor screen. A tool compound named MTX-216 was highly blocking growth vitro vivo. Single-cell analysis indicated that drug-induced cytotoxicity...
There are a limited number of stimuli-responsive biomaterials that capable delivering customizable dosages therapeutic at specific location and time. This is especially true in tissue engineering regenerative medicine applications, where it may be desirable for the biomaterial to also serve as scaffolding material. Therefore, purpose this study was engineer traditionally non-stimuli responsive scaffold thermally so could used on-demand drug delivery applications. Fibrin hydrogels frequently...
Summary Targeting the distinct metabolic needs of tumor cells has recently emerged as a promising strategy for cancer therapy. The heterogeneous, context-dependent nature cell metabolism, however, poses challenges in identifying effective therapeutic interventions. Here, we utilize various unsupervised and supervised multivariate modeling approaches to systematically pinpoint recurrent states within hundreds lines, elucidate their association with lineage growth environments, uncover...
<div>Abstract<p>Neurofibromin 1 (NF1) loss of function (LoF) mutations are frequent in melanoma and drive hyperactivated RAS tumor growth. NF1<sup>LoF</sup> cells, however, do not show consistent sensitivity to individual MEK, ERK, or PI3K/mTOR inhibitors. To identify more effective therapeutic strategies for treating melanoma, we performed a targeted kinase inhibitor screen. A tool compound named MTX-216 was highly blocking growth <i>in vitro</i>...
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<p>Supplementary Dataset Legends</p>
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