A5077004925- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA regulation and disease
- RNA Research and Splicing
- Genetics and Neurodevelopmental Disorders
École Polytechnique Fédérale de Lausanne
2022
Swiss Cancer Center Léman
2022
University of Lausanne
2022
Many human cancers manifest the capability to circumvent attack by adaptive immune system. In this work, we identified a component of evasion that involves frequent up-regulation fragile X mental retardation protein (FMRP) in solid tumors. FMRP represses attack, as revealed cancer cells engineered lack its expression. FMRP-deficient tumors were infiltrated activated T impaired tumor growth and enhanced survival mice. Mechanistically, FMRP's immunosuppression was multifactorial, involving...