A5101960204- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Occupational exposure and asthma
- Tracheal and airway disorders
- Mycobacterium research and diagnosis
- Contact Dermatitis and Allergies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vascular Anomalies and Treatments
- Asthma and respiratory diseases
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- Pancreatic and Hepatic Oncology Research
- Tuberculosis Research and Epidemiology
- Lung Cancer Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Myeloid Leukemia Treatments
- Pancreatitis Pathology and Treatment
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Respiratory and Cough-Related Research
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Salivary Gland Tumors Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Chemical Safety and Risk Management
Akita University
2015-2025
Nagaoka Red Cross Hospital
2013-2025
The University of Tokyo
2024
Kazusa DNA Research Institute
2023
Takeda (Norway)
2022
Akita University Hospital
2008-2022
Washington University in St. Louis
1993-2022
Kumamoto University
2021
University of Fukui
2009-2018
Airlangga University
2013
BACKGROUND Cachexia, described as weight loss (mainly in lean body mass [LBM]) and anorexia, is common patients with advanced cancer. This study examined the efficacy safety of anamorelin (ONO‐7643), a novel selective ghrelin receptor agonist, Japanese cancer cachexia. METHODS double‐blind clinical trial (ONO‐7643‐04) enrolled 174 unresectable stage III/IV non–small cell lung (NSCLC) cachexia Japan. Patients were randomized to daily oral (100 mg) or placebo for 12 weeks. The primary endpoint...
Nickel and cobalt, which belong to the same elemental group, are known cause interstitial lung disease bronchial asthma. The ability of these metals injure cells inflammation is likely be important in their pathogenicity but comparative studies rare. Additionally, ultrafine (uf) forms used increasingly little available information on toxicity. Thus inflammatory response following intratracheal instillation particles Co, Ni, TiO2 was compared. Physiological saline (PS) as a vehicle control DQ...
A comparison was made of the bronchoalveolar lavage fluid (BALF) response to ultrafine nickel (Uf-Ni) and standard-sized (Std-Ni). Rats were intratracheally instilled with 0, 0.1, 0.5, 1 5 mg Uf-Ni Std-Ni, respectively. At 3 d after instillation, body weight wet lung determined. same time, BALF analyzed for lactate dehydrogenase (LDH), total protein (TP), tumor necrosis factor-alpha (TNF-alpha), cell differential counts. The results showed that indicators injury inflammation in markedly...
<b><i>Objective:</i></b> Chemotherapy with irinotecan plus cisplatin has shown promise in chemo-naïve small-cell lung cancer (SCLC) patients. However, treatment for relapsed or refractory SCLC not been adequately evaluated. This phase II study evaluated the appropriate schedule of as a single agent. was designed to determine antitumor activity, toxicity, and survival previously treated <b><i>Methods:</i></b> Previously patients at least one...
Abstract Background and Aims Decompensated cirrhosis with fibrosis progression causes portal hypertension followed by an oedematous intestinal tract. These conditions weaken the barrier function against bacteria in tract, a condition called leaky gut, resulting invasion bacterial components. Here, we investigated role of outer‐membrane vesicles (OMVs) Escherichia coli , which is representative pathogenic gut‐derived patients pathogenesis cirrhosis. Methods We involvement OMVs humans using...
Allergic diseases have increased in many developed countries including Japan. Doctors are also at risk for allergic from exposure to allergens working conditions and hospital environments. We investigated the factors relating occupational allergy doctors. Self-administered questionnaires were mailed all doctors (n=895) who had previously graduated School of Medicine, Fukui Medical University. Data 307 responders (response rate: 34.3%, male 241, female 66, mean age +/- S.D., 30.8 4.2)...
A 66-year-old male ex-smoker presented with fatigue and non-productive cough, as well a 2-year history of ground-glass opacities. Deterioration on chest radiography increased KL-6 levels coincided the progression diffuse opacities high-resolution CT. Surgical lung biopsy revealed features consistent desquamative interstitial pneumonia. Concurrent skin hardening presence anti-Scl-70 antibodies supported diagnosis systemic sclerosis. Treatment oral corticosteroids proved to be effective,...
In Western studies, lung microbiome changes are reported in patients with chronic obstructive pulmonary disease (COPD) and associated poorer outcomes, but similar studies Asian or those less severe COPD limited. The Acute Exacerbation Respiratory InfectionS Japan (AERIS-J; jRCT1080224632/NCT03957577) was a prospective, non-interventional study to evaluate sputum diversity at baseline after 12 months (V2; exploratory analysis), aged 40-80 years stable (June 2019-June 2022). Baseline...
Although immune checkpoint inhibitors (ICIs) have been shown to improve overall survival (OS) in advanced non-small-cell lung cancer (NSCLC) patients, ICIs sometimes cause various types of immune-related adverse events (irAEs), which lead the interruption ICI treatment. This study aims evaluate clinical significance continuation NSCLC patients with irAEs and assess safety efficacy readministration after their discontinuation due irAEs.We retrospectively identified who were treated first-...
Mucoepidermoid carcinoma of the lung (MEC) is a tumor low malignant potential bronchial gland origin. MEC and adenoid cystic are both considered to be salivary gland-type neoplasms. MECs comparatively rare with an incidence all cancers. We recently encountered case this type cancer. A 60-year-old man was found have abnormal shadow in left lower field on regular check-up for cancer at his company. Chest radiography CT revealed mass measuring 30 mm diameter field. Bronchoscopy protuberant S9...
Recent interventional studies have indicated that some exercise programs beneficial physical and immunological effects for older people. Some evidence suggests involving music and/or a rhythmic movement component may be particularly beneficial.To assess the of new type therapy (MMT) on physical, immunological, hormonal psychosocial health parameters among adults.112 elderly female subjects (average age 73.62 ± 5.50 years) who performed little habitual participated in this randomized,...
Abstract Background Interstitial lung disease (ILD) induced by anti‐programmed‐cell death‐1 (PD‐1) and anti‐PD‐ligand 1 (PD‐L1) is potentially life‐threatening a common reason of the discontinuation therapy. In contrast, an enhancement in antitumor effects was reported patients who developed immune‐related adverse events, including ILD. Although recent evidence suggests that radiologic patterns ILD may reflect severity immune responses to anti‐PD‐1/PD‐L1 therapies, association between...
Adenoid cystic carcinoma of the peripheral lung is a rare entity. We recently encountered patient with adenoid carcinoma. A 75-year-old woman showed nodular lesion 10 mm in diameter right upper field on chest radiography. The diagnosis was unclear, but cancer could not be ruled out. Thoracoscopic biopsy performed, and intraoperative pathological revealed lung. enforced lobectomy mediastinal lymph node dissection to patient. Histopathological examination characteristic cribriform structure....
Alpha-fetoprotein (AFP)-producing lung adenocarcinoma is a rare type of cancer, with its characteristics not yet fully clarified. We recently encountered case this cancer. The patient was 69-year-old man who consulted an internist the chief complaint epigastric pain. Chest X-ray and CT revealed lobulated mass measuring 70 mm in diameter right lower field metastasis hilar lymph nodes. Of tumor markers, serum AFP elevated (4620 ng/ml), carcinoembryonic antigen carbohydrate 19-9 were also...
Objectives Ultrasound (US) lung comets are often observed in patients with interstitial disease or congestive heart failure, but few studies have explored the clinical importance of US former condition. We whether comet number could be used to assess severity pneumonia. Methods Forty stable pneumonia were examined. Lung evident on transthoracic imaging 12 selected regions posterior chest wall analyzed. defined accompanied by thickened and irregular pleural lines as comets; these predominated...
Metal‐Induced Lung Disease: Lessons from Japan's Experience: Yukinori Kusaka, et al. Department of Environmental Health, School Medicine, Fukui Medical University —Metals inducing occupational respiratory diseases, e.g. metal fever, acute and chronic pneumonia, asthma, bronchitis, obstructive lung disease, pulmonary fibrosis cancer are described. The metals mentioned the following: aluminum, antimony, arsenic, barium, beryllium, cadmium, chromium, cobalt, copper, iron, lithium, manganese,...
Ectopic thymoma rarely presents as an intrathoracic tumor. We report a case of ectopic presenting giant right tumor that was treated with resection. The patient 50-year-old Japanese woman who presented the chief complaint chest pain. Detailed examination revealed solid measuring 15 × 10 8 cm in diameter, clear border. Imaging findings suggested solitary fibrous tumor, and surgery performed. At surgery, found to be adherent diaphragm, mediastinal pleura, lower lobe lung, although it could...