About
Contact & Profiles
A5058670283
Research Areas
- Receptor Mechanisms and Signaling
- Mast cells and histamine
- Adenosine and Purinergic Signaling
- Cholinesterase and Neurodegenerative Diseases
- Amino Acid Enzymes and Metabolism
- Pharmacological Receptor Mechanisms and Effects
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Heinrich Heine University Düsseldorf
2016-2021
10.1016/j.ejmech.2018.02.015
article
EN
European Journal of Medicinal Chemistry
2018-02-16
10.1016/j.bmcl.2019.08.016
article
EN
Bioorganic & Medicinal Chemistry Letters
2019-08-09
Adenosine A1/A2A receptors (A1R/A2AR) represent targets in nondopaminergic treatment of motor disorders such as Parkinson's disease (PD). As an innovative strategy, multitargeting ligands (MTLs) were developed to achieve comprehensive PD therapies simultaneously addressing comorbid symptoms sleep disruption. Recognizing the wake-promoting capacity histamine H3 receptor (H3R) antagonists combination with "caffeine-like effects" A1R/A2AR antagonists, we designed A1R/A2AR/H3R MTLs, where a...
10.1021/acs.jmedchem.0c00914
article
EN
Journal of Medicinal Chemistry
2021-06-09
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