A5066517933- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Cancer Immunotherapy and Biomarkers
- Crystal structures of chemical compounds
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- RNA Interference and Gene Delivery
- Metal-Catalyzed Oxygenation Mechanisms
- Adenosine and Purinergic Signaling
- Ferroptosis and cancer prognosis
- Organometallic Compounds Synthesis and Characterization
- Autophagy in Disease and Therapy
- Catalytic C–H Functionalization Methods
- Synthesis of Organic Compounds
- Galectins and Cancer Biology
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
Guangxi Normal University
2016-2025
Ministry of Education of the People's Republic of China
2025
Chinese People's Liberation Army
2015-2024
The University of Texas MD Anderson Cancer Center
2020-2023
China University of Mining and Technology
2022
South China Agricultural University
2019
State Council of the People's Republic of China
2017
Nankai University
2013-2015
Chongqing Vocational Institute of Engineering
2013
An efficient strategy for the synthesis of benzofuro[2,3- b]pyrazines was developed. These tricyclic scaffolds were formed through a multistep cascade sequence, which includes double insertion isonitriles and chemoselective bicyclization. In this reaction, nanopalladium used as recyclable catalyst. Product 3w exhibited excellent anticancer activity toward T-24 (IC50 = 12.5 ± 0.9 μM) HeLa 14.7 1.6 cells. We also explored action mechanism on
Two G-quadruplex ligands [Pt(L(a))(DMSO)Cl] (Pt1) and [Pt(L(b))(DMSO)Cl] (Pt2) have been synthesized fully characterized. The two complexes are more selective for SK-OV-3/DDP tumor cells versus normal (HL-7702). It was found that both Pt1 Pt2 could be a telomerase inhibitor targeting DNA. This is the first report demonstrating telomeric, c-myc, bcl-2 G-quadruplexes caspase-3/9 preferred to bind with rather than Pt1, which also can induce senescence apoptosis. different biological behavior of...
Agents inducing both apoptosis and autophagic death can be effective chemotherapeutic drugs. In our present work, we synthesized two organometallic gold(III) complexes harboring C^N ligands that structurally resemble tetrahydroisoquinoline (THIQ): Cyc-Au-1 (AuL1Cl2, L1 = 3,4-dimethoxyphenethylamine) Cyc-Au-2 (AuL2Cl2, L2 methylenedioxyphenethylamine). screening their in vitro activity, found gold exhibited lower toxicity, resistance factors, better anticancer activity than those of...
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic cell death (ICD), representing a "second hit" from host system tumor cells. Although chemo-immunotherapy is highly promising, ICD inducers remain sparse with vague drug–target mechanisms. Here, we report an endoplasmic reticulum stress-inducing cyclometalated Ir(III)–bisNHC complex (1a) new inducer, and based on this...
Developing anticancer drugs with low side effects is an ongoing challenge. Immunogenic cell death (ICD) has received extensive attention as a potential synergistic modality for cancer immunotherapy. However, only limited set of or treatment modalities can trigger ICD response and none them have cytotoxic selectivity. This provides incentive to explore strategies that might provide more effective inducers free adverse effects. Here, we report metal-based complex ( Cu-1 ) disrupts cellular...
The development and optimization of metal-based anticancer drugs with novel cytotoxic mechanisms have emerged as key strategies to overcome chemotherapeutic resistance side effects. Agents that simultaneously induce ferroptosis autophagic death received extensive attention potential modalities for cancer therapy. However, only a limited set or treatment can synergistically tumor cell death. In this work, we designed synthesized four new cycloplatinated (II) complexes harboring an...
The development of anticancer drugs to treat triple-negative breast cancer (TNBC) is an ongoing challenge. Immunogenic cell death (ICD) has garnered considerable interest worldwide as a promising synergistic modality for chemoimmunotherapy. However, only few or treatment modalities can trigger ICD response and none them exert clinical effect against TNBC. Therefore, new agents with potentially effective chemoimmunotherapeutic are required. In this study, five cyclometalated Ir(III) complexes...
Agents with multiple modes of tumor cell death can be effective chemotherapeutic drugs. One example a bimodal approach is an agent that induce both apoptosis and autophagic death. Thus far, no clinical anticancer drug has been shown to simultaneously these pathways. Mono-functional platinum complexes are potent candidates which act through mechanisms distinct from cisplatin. Here, we describe the synthesis characterize two mono-functional containing 8-substituted quinoline derivatives as...
A platinum(ii) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) association with potent ER stress and reactive oxygen species generation, followed by activation of damage-associated molecular pattern signals immune responses. Importantly, Pt exhibits anti-tumour activities two independent mouse models via immunogenic cell death pathway.
Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and vaccines has been compromised by rapidly spreading SARS-CoV-2 variants. Viruses can hijack glycosylation machinery host cells to shield themselves from host's immune response attenuate antibody efficiency. However, it remains unclear if targeting on viral spike protein impair infectivity its variants.We adopted flow cytometry, ELISA, BioLayer interferometry approaches assess binding...
Abstract Latexin (LXN) is abundant in macrophages and plays critical roles inflammation. Much known about atherosclerosis, the role of macrophage LXN atherosclerosis has remained elusive. Here, expression human mouse atherosclerotic lesions was examined by immunofluorescence immunohistochemistry. knockout LXN/ApoE double-knockout mice were generated to evaluate functions atherosclerosis. Bone marrow transplantation (BMT) experimentation carried out determine whether regulates We found that...
A novel and efficient protocol for the regioselective synthesis of 3-styrylcoumarins from readily available cinnamic acids coumarins is presented. The reaction proceeds via a decarboxylative cross-coupling mediated by catalytic amount Pd(OAc)2, with Ag2CO3 as an oxidant, 1,10-phenanthroline ligand. plausible mechanism this process depicted, resulting show excellent fluorescence quantum yields.
Three cobalt(<sc>ii</sc>) complexes with 8-hydroxyquinoline derivatives as ligands were synthesized. They exhibited strong proliferation inhibition activity against T-24 cancer cells, which induced cell apoptosis <italic>via</italic> intrinsic caspase-mitochondria pathways.
Autophagy has been recognized as one of the pathways for eliciting immunogenic cell death (ICD). However, specific molecular target responsible autophagy-mediated ICD not yet elucidated. Here, we report that an oxoisoaporphine alkaloid-modified iridium(III) complex (2a) displays autophagy-inducing activity. Through unbiased thermal proteome profiling (TPP), this new was found to interact with lysosomal protease cathepsin D (Cat D). Subsequent cellular and biochemical assays─including shift...