Alzheimer's disease (AD) is a neurodegenerative disorder and the commonest cause of dementia among aged people. D-galactose (D-gal) senescence agent, while aluminium known neurotoxin linked to pathogenesis AD. The combined administration rats with d-gal chloride (AlCl3) considered be an easy cheap method obtain animal model plant Centella asiatica (CA) reported exert neuroprotective effects both in vitro vivo. Therefore, this study explored protective CA on cognition brain ultrastructure...

To determine the anti-inflammatory and antinociceptive activities of Mitragyna speciosa Korth methanol extract in rodents.Anti-inflammatory activity was evaluated using carrageenan-induced paw edema cotton pellet-induced granuloma tests rats. Antinociceptive measured writhing test hot plate mice, formalin All drugs extracts were diluted dH(2)O administered through intraperitoneal route. Results analyzed one-way ANOVA followed by Dunnett's for multiple comparisons among groups.Results showed...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD characterised clinically by decline in cognitive functions and pathologically presence of neurofibrillary tangles (NFTs), deposition beta-amyloid (Aβ) plaque synaptic dysfunction brain. Centella asiatica (CA) valuable herb being used widely African, Ayurvedic, Chinese traditional medicine to reverse impairment enhance functions. This study aimed evaluate effectiveness CA...

Postpartum depression (PPD) is a psychiatric disorder that occurs in 10-15% of childbearing women. It hypothesized omega-3 fatty acids, which are components fish oil, may attenuate symptoms. In order to examine this hypothesis, the animal model postpartum was established present study. Ovariectomized female rats underwent hormone-simulated pregnancy (HSP) regimen and received progesterone estradiol benzoate or vehicle for 23 days, mimicking actual rat's pregnancy. The days after hormone...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cholinergic dysfunctions and impaired redox homeostasis. The plant Centella asiatica (CA) renowned for its nutritional benefits herbal formulas promoting health, enhancing cognition, neuroprotective effects. present study aims to investigate the protective role of CA on D-gal/AlCl₃-induced cognitive deficits in rats. rats were divided into six groups administered donepezil 1 mg/kg/day, (200, 400, 800 mg/kg/day) D-gal...

Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia, characterised by multiple cognitive impairments personality changes. Different methods including chemicals have been used to induce AD-like symptoms in rodent order screen many therapeutic drugs for a variety dysfunctions. Articles from reliable databases such as Google Scholar, Science Direct, PubMed, Scopus, Ovid were searched retrieved with following descriptors: 'Alzheimer's Disease', Cognitive...

Neurotransmission and cognitive dysfunctions have been linked to old age disorders including Alzheimer’s disease (AD). Aluminium is a known neurotoxic metal, whereas d-galactose (d-gal) has established as senescence agent. WIN55,212-2 (WIN), potent cannabinoid agonist which partially restores neurogenesis in aged rats. The current study aimed explore the therapeutic potentials of WIN on chloride (AlCl3) d-gal-induced rat models with dysfunction. Healthy male albino Wistar rats weighing...

Background: Alzheimer's disease (AD) a neurodegenerative disorder is leading cause of dementia in the elderly population. The concurrent dosing rats with aluminium chloride (AlCl3) and D-galactose (D-gal) regarded an effective approach for developing animal model to study AD. Centella asiatica (CA) demonstrates neuroprotective effects both vitro vivo studies. This research investigated protective CA against neurodegeneration hippocampus activation astrocytes treated AlCl3 D-gal. Materials...

The increase in endothelial permeability often promotes edema formation various pathological conditions. Tumor necrosis factor-alpha (TNF-α), a pro-atherogenic cytokine, impairs barrier function and causes dysfunction early stage of atherosclerosis. Asiaticoside, one the triterpenoids derived from Centella asiatica, is known to possess antiinflammatory activity. In order examine role asiaticoside preserving barrier, we assessed its effects on hyperpermeability disruption actin filaments...

This study evaluated the antidepressant-like effect of lipid extract C. striatus in chronic unpredictable mild stress (CUMS) model depression male rats and its mechanism action. The animals were subjected to CUMS for six weeks by using variety stressors. At end protocol, forced swimming test (FST) open field followed biochemical assay. protocol produced depressive-like behavior decreasing body weight, sucrose preference, increasing duration immobility FST. increased plasma corticosterone...

Background: Depression is a psychological disorder which associated with mood swings and cognitive deficits, ranked third among the leading causes of global health care burden. Chronic unpredictable mild stress (CUMS) has been shown to induce depression-like behaviors in rodents, exhibit similarities human form depression. Centella asiatica (CA) an ancient medicinal plant neuroprotective potential. This work aimed assess protective role CA on CUMS-induced rats.
 Methods: Thirty six rats...

Fatin Nadzirah Zakaria1,2, Mohamad Aris Mohd Moklas1, Taufik Hidayat Baharuldin3, Che Norma Mat Taib1, Hasiah Ab Hamid1, Hafizah Abdul Hamid1 and Samaila Musa Chiroma4 Author informationArticle notesCopyright License informationPDFCitations 1Department of Human Anatomy, Faculty Medicine Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, MALAYSIA 2Department Basic

Postpartum depression (PPD) is a familiar problem which associated with about 10-20% of women after child delivery. Fish oil (FO) has therapeutic potentials to many diseases including mood disorders. However, there paucity data on the effects FO supplementation PPD rat model. Hence, this study aimed at investigating in ameliorating depressive-like behaviors by evaluating involvement NLRP3-inflammasome.Thirty six virgin adult female rats (n = 6) were randomly divided into groups; Group 1-3...

Background: There is a dearth of precise information for molecular and cellular mechanisms responsible the development Alzheimer’s disease (AD). However, convincing data from clinical research basic biology have shown that inflammation brain an integral part AD. In this review, role in AD will be highlighted.
 Methods: Articles credible scientific databases, such as ScienceDirect, Scopus, PubMed, Google Scholar Mendeley, were searched retrieved using keywords ‘inflammation’,...

Pathophysiology of postpartum depression (PPD) has been associated with many factors, such as neuroendocrine, neuroinflammation and neurotransmitter changes. Fish oil (FO) improves PPD both in humans animals. However, little is known regards to its pharmacology on a PPD-like rat model. Hence, the current study aimed at investigating effects FO Female rats were induced symptoms then randomly divided into six groups (n = 6) for two experimental protocols. Protocol 1 consisted (2 mL distilled...

Postpartum depression affects 15% of women. Channa striatus, a freshwater fish, is consumed in local Malay population as rejuvenating diet during postpartum period. This study evaluated the antidepressant-like effect lipid extract C. striatus fillet and its mechanism action female Sprague-Dawley rats model depression. The were ovariectomized treated with high dose progesterone estradiol benzoate for 23 days to have hormone-simulated pregnancy. day 24 afterwards considered During period, was...