A5005897298- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Memory and Neural Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Ophthalmology and Eye Disorders
- Motor Control and Adaptation
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Ion channel regulation and function
- Primate Behavior and Ecology
- Neuroscience and Music Perception
University of Bristol
2016-2024
Baylor College of Medicine
2022
University of Leeds
2013
The Na<sup>+</sup>/K<sup>+</sup> ATPase (NKA) is an essential membrane protein underlying the potential in excitable cells. Transmembrane ion transport performed by catalytic α subunits (α1–4). predominant neurons are α1 and α3, which have different affinities for Na<sup>+</sup> K<sup>+</sup>, impacting on kinetics. exchange rate of markedly influences activity expressing them. We investigated distribution function main isoforms subunit expressed mouse spinal cord. NKAα1 immunoreactivity...
The periaqueductal gray (PAG) coordinates behaviors essential to survival, including striking changes in movement and posture (e.g., escape response noxious stimuli vs freezing fear-evoking stimuli). However, the neural circuits underlying expression of these remain poorly understood. We demonstrate vivo rats that activation ventrolateral PAG (vlPAG) affects motor systems at multiple levels neuraxis through following: (1) differential control spinal neurons forward sensory information...
The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by identification neurons male rat ventrolateral PAG (vlPAG) that encode memory through signalling onset and offset an auditory-conditioned stimulus during presentation unreinforced conditioned tone (CS+) retrieval. Some units only display CS+ or responses, two signals differ extinction sensitivity, suggesting they are independent each other. In addition, understanding cerebellar contributions to survival...
Pathways arising from the periphery that target inferior olive [spino-olivocerebellar pathways (SOCPs)] are a vital source of information to cerebellum and modulated (gated) during active movements. This limits their ability forward signals climbing fibers in cerebellar cortex. We tested hypothesis temporal pattern gating is related predictability sensory signal. Low-intensity electrical stimulation ipsilateral hindlimb awake rats evoked field potentials C1 zone copula pyramidis Responses...
Abstract The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by identification neurons rat ventral PAG (vPAG) that encode memory through signalling onset and offset an auditory conditioned stimulus during presentation unreinforced tone retrieval. Some units only display CS+ or responses two signals differ extinction sensitivity, suggesting they are independent each other. In addition, understanding cerebellar contributions to survival circuits advanced discovery...
The extinction of fear memories is an important component in regulating defensive behaviors, contributing toward adaptive processes essential for survival. cerebellar medial nucleus (MCN) has bidirectional connections with the ventrolateral periaqueductal gray (vlPAG) and implicated regulation multiple aspects fear, such as conditioned learning expression motor outputs. However, it unclear how communication between MCN vlPAG changes during extinction. We use dynamic causal models (DCMs) to...