A5063334552- Computational Drug Discovery Methods
- Synthesis and biological activity
- Free Radicals and Antioxidants
- Click Chemistry and Applications
- Analytical Chemistry and Chromatography
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Bioinformatics and Genomic Networks
- Breast Implant and Reconstruction
- Multicomponent Synthesis of Heterocycles
- Cholinesterase and Neurodegenerative Diseases
- Chemical Synthesis and Analysis
- Pesticide and Herbicide Environmental Studies
- Chemistry and Chemical Engineering
- Phytochemicals and Antioxidant Activities
- Adenosine and Purinergic Signaling
- Inflammatory mediators and NSAID effects
- Chemical Thermodynamics and Molecular Structure
- Machine Learning in Bioinformatics
- Metal complexes synthesis and properties
- Advanced Chemical Sensor Technologies
- Pharmacological Receptor Mechanisms and Effects
- Electrospun Nanofibers in Biomedical Applications
- Advancements in Transdermal Drug Delivery
Universidad Central "Marta Abreu" de las Villas (UCLV)
2011-2023
Universidade do Porto
2007-2015
Rede de Química e Tecnologia
2007-2013
Universidade de Vigo
2012
Universidade de Santiago de Compostela
2007
Soft tissues are commonly fiber-reinforced hydrogel composite structures, distinguishable from hard by their low mineral and high water content. In this work, we proposed the development of 3D printed constructs biopolymers chitosan (CHI) cellulose nanofibers (CNFs), both without any chemical modification, which processing did not incorporate crosslinking. The unique mechanical properties native offer new strategies for design environmentally friendly performance composites. here bioinspired...
Background: Silicone gel breast implants are associated with long-term adverse events, including capsular contracture, reported incidence rates as high 50 percent. However, it is not clear how long the follow-up period should be and whether there any association estrogen or menopausal status. In addition, placement of Baker grade II subjects in majority reports has been data sets controls instead contracture. Methods: A retrospective medical study (1998 to 2004) was performed women (n = 157)...
Recent advances in nanocellulose technology have revealed the potential of crystalline cellulose nanofibers to reinforce materials which are useful for tissue engineering, among other functions. However, low biodegradability can possess some problems biomedical applications. In this work, alginate particles with encapsulated enzyme cellulase extracted from Trichoderma reesei were prepared biodegradation nanofibers, carrier system could be incorporated engineering biomaterials degrade...
There are several indices that provide an indication of different types on the performance QSAR classification models, being area under a Receiver Operating Characteristic (ROC) curve still most powerful test to overall assess such performance. All ROC related parameters can be calculated for both training and sets, but, nevertheless, neither them constitutes absolute indicator by themselves. Moreover, one biggest drawbacks is computing time needed obtain curve, which naturally slows down...
The systemic information enclosed in microarray data encodes relevant clues to overcome the poorly understood combination of genetic and environmental factors Parkinson's disease (PD), which represents major obstacle understand its pathogenesis develop disease-modifying therapeutics. While several gene prioritization approaches have been proposed, none dominate over rest. Instead, hybrid seem outperform individual approaches. A consensus strategy is proposed for PD related from mRNA based on...
Chemical carcinogenicity is of primary interest because it drives much the current regulatory actions regarding new and existing chemicals conventional experimental tests take around 3 years to design, conduct, interpret in addition costing hundreds millions dollars, skilled personnel hours, animal lives. Thus, theoretical approaches such as one proposed here, quantitative structure–activity relationship (QSAR), are increasingly used for assessing risks environmental chemicals, since they...
Blockade of the human Ether-à-go-go Related Gene (hERG) potassium channel by small molecules can prolong QT interval, leading to fatal cardiotoxicity. Numerous drugs have been withdrawn from market due cardiac side effects, underscoring need for early identification hERG toxicity. Despite several classification machine learning (ML) models having developed this end, robustness, class imbalance, and interpretability are still challenges. Using largest public database inhibition, work...
Abstract Worldwide, legislative and governmental efforts are focusing on establishing simple screening tools for identifying those chemicals most likely to cause adverse effects without experimentally testing all of regulatory concern. This is because even the basic biological compounds concern, apart from requiring a huge number test animals, would be neither resource nor time effective. Thus, alternative approaches such as one proposed here, quantitative structure-activity relationship...