A5023487609- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Cancer-related cognitive impairment studies
- Breast Cancer Treatment Studies
- Advanced Biosensing Techniques and Applications
- Lung Cancer Research Studies
Case Western Reserve University
2024
University School
2024
National Heart Lung and Blood Institute
2020-2021
National Institutes of Health
2020-2021
Abstract Genetic mutations associated with acute myeloid leukemia (AML) also occur in age-related clonal hematopoiesis, often the same individual. This makes confident assignment of detected variants to malignancy challenging. The issue is particularly crucial for AML posttreatment measurable residual disease monitoring, where results can be discordant between genetic sequencing and flow cytometry. We show here that it possible distinguish from hematopoiesis resolve immunophenotypic identity...
1082 Background: Clonal hematopoiesis (CH) has been associated with reduced overall survival and is shown to be increased in patients solid tumors after receiving chemotherapy radiotherapy. However, the clinical implications of these observations have not prospectively evaluated among different racial groups. This study was initiated an urban cancer center CH rates before therapy a racially diverse population. Methods: Women aged ≥18 newly diagnosed non-metastatic breast provided written...
Abstract Genetic mutations associated with acute myeloid leukemia can also be detected in age-related clonal hematopoiesis, making confident assignment of variants to malignancy challenging particularly the post-treatment setting. This has implications for measurable residual disease monitoring, where relationship between sequencing and flow cytometry is imperfect. We show, using whole-genome-sequencing informed patient-personalized single-cell DNA antibody-oligonucleotide sequencing, that...
<div>Abstract<p>Genetic mutations associated with acute myeloid leukemia (AML) also occur in age-related clonal hematopoiesis, often the same individual. This makes confident assignment of detected variants to malignancy challenging. The issue is particularly crucial for AML posttreatment measurable residual disease monitoring, where results can be discordant between genetic sequencing and flow cytometry. We show here that it possible distinguish from hematopoiesis resolve...
<p>Supplementary Data</p>
<div>Abstract<p>Genetic mutations associated with acute myeloid leukemia (AML) also occur in age-related clonal hematopoiesis, often the same individual. This makes confident assignment of detected variants to malignancy challenging. The issue is particularly crucial for AML posttreatment measurable residual disease monitoring, where results can be discordant between genetic sequencing and flow cytometry. We show here that it possible distinguish from hematopoiesis resolve...
<p>Supplementary Data</p>