A5074647405- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Colorectal Cancer Surgical Treatments
- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Kruppel-like factors research
- Galectins and Cancer Biology
Centro de Investigaciones Biológicas Margarita Salas
2022-2024
Cadherin-17 (CDH17), a marker of differentiation in intestinal cells, binds and activates α2β1 integrin to promote cell adhesion proliferation colorectal cancer (CRC) metastasis. Furthermore, CDH17 associates with p120- β-catenin manner yet be fully elucidated. In this report, we explored the molecular mediators involved association, their contribution CRC dissemination potential therapeutic implications. Proteomic confocal analyses were employed identify validate interactors. Functional...
Abstract Interleukin 13 receptor alpha 2 (IL13Rα2) is a relevant therapeutic target in glioblastoma (GBM) and other tumors associated with tumor growth invasion. In previous study, we demonstrated that protein tyrosine phosphatase 1B (PTP1B) key mediator of the IL-13/IL13Rα2 signaling pathway. PTP1B regulates cancer cell invasion through Src activation. However, PTP1B/Src downstream mechanisms modulate process remain unclear. present research, have characterized interactome PTP1B-associated...
Abstract The necessity to accurately predict recurrence and clinical outcome in early stage colorectal cancer (CRC) is critical identify those patients who may benefit from adjuvant chemotherapy. Here, we developed validated a gene‐based risk‐score algorithm for patient stratification personalised treatment disease based on alterations the secretion of metastasis‐related proteins. A quantitative label‐free proteomic analysis secretome highly poorly metastatic CRC cell lines with different...
<title>Abstract</title> Cadherin 17 (CDH17) plays a crucial role in the metastatic progression of colorectal cancer (CRC) through its interaction with α2β1 integrin. To further elucidate molecular mechanisms involving CDH17 functions CRC, we examined global expression alterations following silencing various cell lines. Loss resulted marked down-regulation stem (CSC) marker LGR5, leading to inhibition Wnt/β-catenin signaling, suppression pluripotency genes like MYC, and subsequent reduction...
Introduction: Colorectal cancer (CRC) is the second leading cause of death in developed countries, mainly as a consequence metastatic spread. Secreted proteins are essential to communicate cells with tumor- microenvironment, favoring tumor progression and metastasis. The conditioned medium or cellular secretome, including exosomes, has demonstrated be rich source effectors biomarkers metastatization different tumors. Our goal was identify altered secreted fraction highly order determine...