A5027745301- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cerebral Venous Sinus Thrombosis
- Blood disorders and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Retinal and Optic Conditions
- Glioma Diagnosis and Treatment
- Iron Metabolism and Disorders
- Gene expression and cancer classification
- Autophagy in Disease and Therapy
- Soft tissue tumor case studies
- Cancer Mechanisms and Therapy
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Cannabis and Cannabinoid Research
- Lymphoma Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Neutropenia and Cancer Infections
- Appendicitis Diagnosis and Management
- Cancer Cells and Metastasis
- Animal Ecology and Behavior Studies
- Myasthenia Gravis and Thymoma
- CNS Lymphoma Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
Edmond and Lily Safra Children's Hospital
2007-2025
Sheba Medical Center
2004-2023
Tel Aviv University
2016-2021
Assaf Harofeh Medical Center
2005-2016
Pediatrics and Genetics
2015
Boston Children's Hospital
2005
The rhabdoid tumor (RT) predisposition syndromes 1 and 2 (RTPS1 2) are rare genetic conditions rendering young children vulnerable to an increased risk of RT, malignant neoplasms affecting the kidney, miscellaneous soft-part tissues, liver central nervous system (Atypical Teratoid Rhabdoid Tumors, ATRT). Both, RTPS1&2 due pathogenic variants (PV) in genes encoding constituents BAF chromatin remodeling complex, i.e. SMARCB1 (RTPS1) SMARCA4 (RTPS2). In contrast other disorders related PVs such...
Affymetrix human Hu133A oligonucleotide arrays were used to study the expression profile of CD133+ cord blood (CB) and peripheral (PB) using CD133 cell‐surface marker. An unsupervised hierarchical clustering 14,025 valid probe sets showed a clear distinction between cells representing hematopoietic stem cell (HSC) population CD133‐differentiated cells. Two hundred forty‐four genes found be upregulated by at least twofold in CD133‐positive both CB PB compared with CD133‐negative These...
The active components of Cannabis sativa L., Cannabinoids, traditionally used in the field cancer for alleviation pain, nausea, wasting and improvement well-being have received renewed interest recent years due to their diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory activity induction tumor regression. Here we several experimental approaches, which identified delta-9-tetrahydrocannabinol (Delta(9)-THC) an essential mediator cannabinoid antitumoral...
Immune thrombocytopenia (ITP) is an isolated autoimmune condition, often preceded by a viral infection. Vaccines, mainly the measles-mumps-rubella vaccine, have also been associated with increased risk of developing disease. Although some case reports ITP after influenza immunization in adults published, epidemiologic studies examining role vaccine as trigger not conclusively proven causality. We report child 3 occurrences ITP, each within 1 week receiving trivalent inactivated vaccine. He...
10604 Background: Li-Fraumeni Syndrome (LFS) [OMIM #151623] is an autosomal dominant cancer predisposition syndrome caused primarily by germline pathogenic (PV) or likely variants (LPV) in the TP53 gene. Classical (AD) inheritance predicts a 50% risk of for offspring PV/LPV carriers. However, clinical observations Israeli LFS families suggest higher-than-expected prevalence carriers among offspring. This study aims to further investigate this phenomenon. Methods: Relevant data from 36...
Abstract Infantile myofibromatosis (IM), which is typically diagnosed in young children, comprises a wide clinical spectrum ranging from inconspicuous solitary soft tissue nodules to multiple disseminated tumors resulting life-threatening complications. Familial IM follows an autosomal dominant mode of inheritance and linked PDGFRB germline variants. Somatic variants were also detected multifocal lesions. associated with constitutively activate kinase activity the absence its ligand....
Glioblastoma multiforme (GBM) is the most frequent and incurable brain tumor in adults. Although temozolomide (TMZ) does not cure GBM, it has demonstrated anti-GBM activity improved survival (8-14 months) quality of life. We studied mechanisms by which TMZ affects 2 human GBM cell lines; U251-MG U87-MG, aiming to unravel drug-activated cascades enable development combination therapies that will improve efficacy TMZ.The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium assay was used...
Only few reports have looked into the risk of invasive bacterial infection in children with neutropenia that is not malignancy related. The objective current study was to determine clinical significance as a predictor serious (SBI) immunocompetent children. We conducted retrospective case-control including 3 months 18 years age fever ≥ 38°C hospitalized or presenting emergency department. Patients who had ≤ 1000 ANC/μL and blood culture taken were matched for consecutive febrile patients...
Background. The use of competitive inhibitors acetylcholine other than atropine, for patients with organophosphate poisoning, is controversial. Because scopolamine ability to cross the blood-brain barrier better that it has been suggested should be used in poisoning who have central nervous system manifestations. Case Description. A 17-year-old girl was admitted pediatric ward after ingesting chlorpyrifos as a suicidal attempt. She reported vomiting three times. had no symptoms 12 hours and...
The molecular basis of α-thalassemia (α-thal) is complex. use multiplex ligation-dependent probe amplification (MLPA) has offered the possibility identifying more gene deletions causing α-thal. Our objective was to determine two patients with Hb H (β4) disease. By using MLPA in combination comparative genomic hybridization (CGH) we identified novel α-globin cluster deletions: a 30 kb deletion (patient 1) refer as – –JAL and large 216 2) –LOD. Patient 1 compound heterozygote for –α3.7...
Retinal vein occlusion (RVO) and superior ophthalmic thrombosis (SOVT) are rare diseases in the pediatric population; however, neurologic morbidity significant. As published data scarce for these conditions, we present our experience with ocular venous four patients, discuss recommended management evaluation treatment. We suggest performing thrombophilia workup all patients RVO or SOVT. In risk factors additional thrombi, highly recommend initiating anticoagulation therapy. There is a need...
Abstract: EBV association with the rare and usually fatal tLELC has been well documented, but not thoroughly studied, in literature. A symptomatic 16-year-old boy was admitted for a locally advanced, inoperable EBV-associated tLELC. The diagnosis established by appropriate immunohistology RNA in-situ hybridization (ISH) EBNA. patient responded to induction combination chemotherapy followed consolidation irradiation course given primary mediastinal lesion. Later, upon disease progression, he...