A5065777527- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radical Photochemical Reactions
- Synthesis and Biological Evaluation
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Particle Accelerators and Free-Electron Lasers
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
- Synthesis and Characterization of Pyrroles
- Asymmetric Hydrogenation and Catalysis
- Luminescence and Fluorescent Materials
- Immunodeficiency and Autoimmune Disorders
- Catalytic Alkyne Reactions
- Inorganic Fluorides and Related Compounds
- Inorganic Chemistry and Materials
- Analytical Chemistry and Chromatography
- Chemical and Physical Properties in Aqueous Solutions
- Internet of Things and AI
- Crystal structures of chemical compounds
Indian Institute of Technology Guwahati
2019-2025
Indian Institute of Technology Kharagpur
2021
Inter-University Accelerator Centre
1999
Jawaharlal Nehru University
1986
St. Mary’s Hospital
1983
A sustainable Mn(I)-catalyzed exclusive solvent-dependent functionalization of imidazopyridine with maleimide via an electrophilic metalation at the distal (in 2,2,2-trifluoroethanol (TFE)) and chelation assisted proximal tetrahydrofuran (THF)) has been developed. The strategy was successfully applied to drug Zolimidine a broad range substrates, thereby reflecting method's versatility.
A Mn(I)-catalyzed site-selective nondirected C3-maleimidation of quinoxaline is established. Herein, the electrophilic C3-metalation precedes over o-directed strategy to access diversely substituted quinoxaline-appended succinimides. The products undergo PIFA-promoted C(sp2)-C(sp3) spirocyclization via π-electrons drifting from aryls and Selectfluor-mediated dehydrogenation succinimide at room temperature.
Bu4NI-catalyzed regioselective N2-methylation, N2-alkylation, and N2-arylation of tetrazoles have been achieved using tert-butyl hydroperoxide (TBHP) as the methyl source, alkyl diacyl peroxides primary peresters secondary tertiary sources, aryl arylating source. These reactions proceed without pre-functionalization tetrazole in absence any metal catalysts. Here, serve dual role oxidants well alkylating or agents. Based on DFT calculations, it was found that spin density, transition-state...
A Cu(I)-mediated cascade cyclization/annulation of unprotected o-alkynylanilines with maleimides in one pot is developed. The protocol offers sequential formation C–N and two C–C bonds to deliver fused benzo[a]carbazoles having free NH skeletons. annulated products display fluorescence emission the range 485–502 nm a large Stokes shift lifetime ∼17 ns. 3aa displays AEE behavior ethanol/hexane system possesses marigold-flower-like morphology at aggregated state. Cell viability assays...
Multifaceted application potential of AEEgens in bioimaging, theranostics, chemo/biosensors, mechanochromics, solar cells, and organic photoelectronics opens up a new research paradigm to develop design more such compounds. Herein, quinoxaline N-directed Ru(II)-catalyzed oxidative annulation 2-arylquinoxalines with internal alkynes leads the formation highly luminescent annulated quaternary ammonium salts presence Cu(OAc)2·H2O oxidant. While synthesized compounds exhibit emissions...
A Cu(OTf) 2 -mediated regioselective dearomative aryl-hydroxylation across the C(sp )N bond of 2-aryl quinoxalines and bis- N -arylation (benz)imidazoles were developed using aryl boronic acids.
A visible light-driven di-functionalization of maleimide with disulfide and in situ -generated singlet oxygen offers selective 1,2-thiohydroxylation under additive-free conditions.
An EnT-mediated C3-N-heteroarylation of 2-aryl quinoxalines via decarboxylative radical-radical cross-coupling (C(sp2)-C(sp2)) with oxime esters is presented. Upon photoactivation, the triplet energy photocatalyst transferred to both reacting partners (oxime ester and 2-phenylquinoxaline). The excited undergoes fragmentation a C-centered N-heteroaryl radical an N-centered imine radical. former attacks C3 site quinoxaline diradical, while latter acts as hydrogen atom abstractor (HAA)....
Demonstrated here is an external photo-sensitizer-free (auto-sensitized) singlet oxygen-enabled solvent-dependent tertiary hydroxylation and aryl-alkyl spiro-etherification of C3-maleimidated quinoxalines. Such "reagent-less" photo-oxygenation at Csp
Abstract One of the cyano group γ‐keto malononitrile gets hydrolyzed selectively to an amide in presence copper(II) acetate monohydrate. The situ generated undergo intramolecular dehydrative cyclization a 1,2‐dihydropyridone intermediate. Further annulation with internal alkyne same pot produce fused isoquinolone, 4‐oxo‐2,6,7‐triaryl‐4 H ‐pyrido[2,1‐ ]isoquinoline‐3‐carbonitrile. This one‐pot process is associated formation one C−C, two C−N, C=C and C=O bonds. final synthesis four‐step...
A base-mediated 1,1-difunctionalization of vinylene carbonate has been achieved using two different nucleophiles, namely, thiol and alcohol, with the assistance air (O2). In alcoholic solvents, decarboxylation occurs at room temperature to provide a 1,1-difunctionalized product, where serves as an ethynol (C2) synthon in this three-component reaction. On other hand, acetonitrile, exclusive hydrothiolation under basic conditions temperature. This method offers one-pot decarboxylative...
Developed here is a highly fluorescent organic N,O bidentate BF
A Ru(II) catalyzed regioselective Heck-type C-H olefination of isoxazole with unactivated allyl phenyl sulfone is revealed. The solvent DCM offers dual sp2-sp2 activation via an N-directed strategy, leading to ortho-olefinated isoxazoles exclusive E-selectivity. On the other hand, in DCE solvent, serves as nitrile synthon and leads o-olefinated benzonitrile. At a higher temperature (110 °C) DCE, after ortho-olefination mediated cleavage delivered functionality.
A cobalt(III)‐catalyzed dual C(sp2)−H/C(sp2)−H activation of 2‐arylimidazopyridines and its annulation with N‐substituted maleimides leads to polycyclic aromatic heterocycles. This sustainable oxidative uses earth‐abundant, less toxic, cost‐effective cobalt(III) catalyst that complement expensive 2nd 3rd‐row metals. features a broad substrate scope very good functional group tolerance. These maleimide‐fused imidazopyridines display strong fluorescence in the region 527− 536 nm Stokes shift...
Summary Double antibody radioimmunoassays have been developed for the quantification of anti-IgG, anti-C3, anti-C3c, anti-C3d and anti-C4 antibodies determination their binding constants. Assays were undertaken on 53 polyspecific antiglobulin reagents obtained from a variety commercial public sources. Concentrations anti-IgG varied 1.2 to 12.8 μg/ml in products 0.4 6.0 products. anti-C3 anti-C3c 0.1 1.0 most but concentrations by more than 100-fold 0.02 6.5 μg/ml. 0.05 0.7 <0.01 1.3 0.18...