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Paweł Łukasik

ORCID: 0000-0003-4812-497X
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About
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A5088591972
Research Areas
  • Cancer-related Molecular Pathways
  • Advanced Breast Cancer Therapies
  • Synthesis and Characterization of Heterocyclic Compounds
  • Synthesis and biological activity
  • Microtubule and mitosis dynamics
  • Synthesis of heterocyclic compounds
  • Cancer Mechanisms and Therapy
  • Protein Degradation and Inhibitors

Pomeranian Medical University
 2021

University of Nottingham
 2012

 Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
OPENALEX - Publications 
Paweł Łukasik Sherifa Elabar Frankie Lam Hao Shao Xiangrui Liu and 2 more Abdullah Y. Abbas Shudong Wang

10.1016/j.ejmech.2012.09.034 article EN European Journal of Medicinal Chemistry 2012-10-03
 Synthesis and Anticancer Activity of Mitotic-Specific 3,4-Dihydropyridine-2(1H)-thiones
OPENALEX - Publications 
Magdalena Perużyńska Aleksandra Borzyszkowska-Ledwig Jacek G. Sośnicki Łukasz Struk Tomasz J. Idzik and 6 more Gabriela Maciejewska Łukasz Skalski Katarzyna Piotrowska Paweł Łukasik Marek Droździk Mateusz Kurzawski

Most anticancer drugs target mitosis as the most crucial and fragile period of rapidly dividing cancer cells. However limitations classical chemotherapeutics drive search for new more effective selective compounds. For this purpose structural modifications previously characterized pyridine aalog (S1) were incorporated aiming to obtain an antimitotic inhibitor satisfactory specific activity. Structure-activity relationship analysis compounds against a panel cell lines allowed select compound...

10.3390/ijms22052462 article EN International Journal of Molecular Sciences 2021-02-28
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