A5011587382- Ethics in Business and Education
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Critical Theory and Philosophy
- Political Philosophy and Ethics
- Political Economy and Marxism
- HIV-related health complications and treatments
- Ethics in medical practice
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Eastern European Communism and Reforms
- Urbanization and City Planning
- Cancer, Lipids, and Metabolism
- Advanced MRI Techniques and Applications
- Pulsars and Gravitational Waves Research
- Lipid metabolism and disorders
- Legal Education and Practice Innovations
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Information and Cyber Security
- Advanced Malware Detection Techniques
- Atherosclerosis and Cardiovascular Diseases
- Gamma-ray bursts and supernovae
- Economic Theory and Institutions
Regeneron (United States)
2023-2025
AstraZeneca (Sweden)
2025
AstraZeneca (United States)
2020-2024
Washington University in St. Louis
2024
New York Medical College
2024
Johns Hopkins University
2010-2023
Johns Hopkins Hospital
2023
The University of Texas at Austin
2023
University of Kansas
2001-2022
Johns Hopkins University Applied Physics Laboratory
2016-2022
Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies possible; however, their safety efficacy have not been compared.To test whether MSCs safe effective in patients with left ventricular (LV) dysfunction due to ICM.A phase 1/2 randomized comparison (POSEIDON study) US tertiary-care referral hospital of 30 LV ICM between April 2, 2010, September 14, 2011, 13-month follow-up.Twenty million, 100 or 200...
Coronary artery disease (CAD) has been associated with HIV infection, but data are not consistent.
Abstract Background and Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder characterized by severely elevated LDL cholesterol (LDL-C) premature atherosclerotic cardiovascular disease. In the pivotal Phase 3 HoFH trial (NCT03399786), evinacumab significantly decreased LDL-C in patients with HoFH. This study assesses long-term safety efficacy of adult adolescent Methods this open-label, single-arm, (NCT03409744), aged ≥12 years who were evinacumab-naïve or had...
Heightened immune activation among human immunodeficiency virus (HIV)-infected persons may contribute to atherosclerosis. We assessed associations of serologic markers monocyte activation, soluble CD163 (sCD163) and CD14 (sCD14), chemoattractant protein 1 (CCL2) with subclinical atherosclerosis men those without HIV infection in the Multicenter AIDS Cohort Study.We performed noncontrast computed tomography on 906 (566 HIV-infected 340 HIV-uninfected men), 709 whom also underwent coronary...
Transendocardial stem cell injection (TESI) with mesenchymal cells improves remodeling in chronic ischemic cardiomyopathy, but the effect of site remains unknown.To address whether TESI exerts its effects at only or also remote areas, we hypothesized that segmental myocardial scar and ejection fraction improve to a greater extent injected than noninjected segments.Biplane ventriculographic endocardial tracings were recorded. was guided 10 sites infarct-border zones. Sites mapped according...
Despite bearing a disproportionate burden of heart failure (HF), Black and Hispanic individuals have been poorly represented in HF clinical trials. Underrepresentation trials limits the generalizability findings to these populations may even introduce uncertainties hesitancy when translating trial data care people from underrepresented groups. The Heart Failure Collaboratory, consortium stakeholders convened enhance therapeutic development, has dedicated improving recruitment strategies for...
BACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) levels due to profoundly defective LDL receptor (LDLR) function. Given that LDL-C starts in utero, atherosclerosis often presents during childhood or adolescence, creating largely unmet need for aggressive LDLR-independent lipid-lowering therapies young patients with HoFH. Here we present the first evaluation of efficacy and...
Starting from May 2023, the LIGO Scientific, Virgo and KAGRA Collaboration has been conducting fourth observing run with improved detector sensitivities an expanded network including KAGRA. Accordingly, it is vital to optimize detection algorithm of low-latency search pipelines, increasing their gravitational waves compact binary coalescences. In this work, we discuss several new features developed for ranking statistics GstLAL-based inspiral pipeline, which mainly consist signal...
ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab < 5‐year‐old HoFH. Population pharmacometric models characterizing exposure LDL‐C response accounting for apheresis effect ≥ were adapted growth maturation to predict compare concentrations across age/weight groups virtual 6‐month‐old...
In the present study, we investigate hemodynamics inside left atrium (LA) and understand its impact on development of ventricular flow patterns. We construct heart model using dynamic-computed tomographic images perform simulations an immersed boundary method based solver. show that atrial is characterized by a circulatory generated pulmonary veins (LPVs) direct stream from right (RPVs). The complex interaction vortex rings formed each PVs leads to breakup annihilation, thereby producing...
The blood–brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to brain. In rodents, regadenoson activation adenosine A2A receptors causes transient BBB disruption and increased drug concentrations in normal This study was conducted evaluate if would increase intra-tumoral temozolomide patients with glioblastoma. Patients scheduled for a clinically indicated surgery recurrent glioblastoma were eligible. Microdialysis catheters (MDC) placed...
The myth that ethics has no place in engineering been attacked, and at least some corners of the profession put to rest.1 Another myth, however, is emerging take its place?the engineer as moral hero. A litany saints slowly taking form. field are whistle blowers, especially those who have sacrificed all for their convictions. zeal preachers, gone too far, piling responsibility upon on shoulders engineer. This emphasis, I believe, misplaced. Though engineers members a holds public safety...
A coupled chemo-fluidic computational model for investigating flow-mediated thrombogenesis in infarcted left ventricles (LVs) is proposed. LV thrombus (LVT) formation after the acute myocardial infarction (AMI) may lead to thromboembolic events that are associated with high mortality and morbidity, reliable stratification of LVT risk key managing treatment AMI patients. There have been several studies emphasizing importance blood flow patterns on formation; however, given complex interplay...
Background Blockade of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a potentially attractive mechanism for lowering inflammatory and lipid risk in patients with atherosclerosis. This study aims to assess safety, tolerability, target engagement MEDI6570, high-affinity monoclonal blocking antibody LOX-1. Methods Results phase 1, first-in-human, placebo-controlled (NCT03654313) randomized 88 type 2 diabetes receive single ascending doses (10, 30, 90, 250, or 500 mg)...
International business ethics, as the term implies, cannot be national in character, anymore than international law can character. Yet analogy to is misleading it enlightening. For although we speak of American, German or Japanese law, odd ethics. The reason that ethics usually thought universal. Hence there simply not Despite this, a sense given American does refer opposed but rather approach taken by those who do United States. What characterizes uses special concerned with certain...
Objective: Cytokines released by epicardial fat are implicated in the pathogenesis of atherosclerosis. HIV infection and antiretroviral therapy have been associated with changes body distribution coronary artery disease. We sought to determine whether is greater subclinical Design: studied 579 HIV-infected 353 HIV-uninfected men aged 40–70 years noncontrast computed tomography measure adipose tissue (EAT) volume calcium (CAC). Total plaque score (TPS) subtypes (noncalcified, calcified,...
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate-limiting enzyme in reverse transport. Infusions of acyltransferase have potential to enhance transport and benefit patients with coronary heart disease. The purpose this study was test safety, pharmacokinetic, pharmacodynamic profile MEDI6012. Methods Results This phase 2a double-blind randomized 48 subjects stable disease on a statin single dose or placebo (6:2) (NCT02601560) ascending doses administered...