A5100781906- Pain Mechanisms and Treatments
- Parasitic Diseases Research and Treatment
- COVID-19 Clinical Research Studies
- Connexins and lens biology
- Long-Term Effects of COVID-19
- Pain Management and Placebo Effect
- Heme Oxygenase-1 and Carbon Monoxide
- Reproductive System and Pregnancy
- Motivation and Self-Concept in Sports
- Parasite Biology and Host Interactions
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Head and Neck Cancer Studies
- Respiratory Support and Mechanisms
- Pain Management and Treatment
- Transcranial Magnetic Stimulation Studies
- Wound Healing and Treatments
- Parasites and Host Interactions
- Anesthesia and Neurotoxicity Research
- Lung Cancer Treatments and Mutations
- Thermal Regulation in Medicine
- Biomarkers in Disease Mechanisms
- Transplantation: Methods and Outcomes
- COVID-19 Impact on Reproduction
- Cancer Risks and Factors
Sun Yat-sen University
2012-2025
Sun Yat-sen University Cancer Center
2021-2025
Shenzhen University
2021-2024
Third Affiliated Hospital of Sun Yat-sen University
2012-2024
South China University of Technology
2022-2024
Zero to Three
2023
National Natural Science Foundation of China
2023
Affiliated Hospital of Jining Medical University
2021-2022
Data Sciences International (United States)
2022
Northeast Agricultural University
2011-2021
Abstract A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 HCoV-19). We previously reported the clinical features 12 patients with 2019-nCoV infections Shenzhen, China. To further understand pathogenesis COVID-19 and find better ways monitor treat disease 2019-nCoV, we measured levels 48 cytokines blood plasma those patients. Thirty-eight out 2019-nCoV-infected were significantly elevated compared healthy individuals....
This study shows the effective use of MXene-based nanomaterials to improve performance biocomposite sponges in wound healing. In this way, diverse chitin/MXene composite are fabricated by incorporating with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into network chitin sponge (CH), which can prevent massive blood losses and promote healing process bacterial-infected wounds. With addition nanomaterials, hemostatic efficacy...
Abstract Objectives To explore whether the gap junction (GJ) composed by connexin32(Cx32) mediated pyroptosis in renal ischemia-reperfusion(I/R) injury via transmitting miR155-3p, with aim to provide new strategies for prevention and treatment of acute kidney (AKI) after I/R. Methods 8–10 weeks male C57BL/ 6 wild-type mice Cx32 knockdown were divided into two groups respectively: control group I/R group. MCC950 (50 mg/kg. ip.) was used inhibit NLRP3 vivo. Human tubular epithelial cells (HK -...
The purpose of this study was to examine the associations social support and self-efficacy with physical Activity (PA) mediating effect on relationship between PA in Chinese adolescents. Participants included a total 2341 adolescents (aged 12.75 ± 1.46 years). Self-reported instruments, including activity questionnaire for adolescents, revalued scale exercise scale, were used measure activity, self-efficacy. Results showed that (r = 0.29, p < 0.05) 0.43, significant positive predictors among...
Abstract Customizable 3D‐printed biopolymer hydrogels, highly sought after for diabetic wound management, face challenges in clinical application due to weak physical crosslinking within their constituent inks. In this study, a novel chitosan‐based hydrogel ink with dense yet reversible network is subtly designed the rapid situ fabrication of personalized dressing. This robust established through multiple electrostatic and hydrogen bonding interactions between unique carboxymethyl chitosan...
Abstract Postoperative acute kidney injury (AKI) is a severe complication after liver transplantation (LT). Its deterioration and magnification lead to the increase in mortality. Connexin43 (Cx43) mediates direct transmission of intracellular signals between neighboring cells, always considered be potent biological basis organ damage magnification. Thus, we explored effects Cx43 on AKI following LT its related possible mechanism. In this study, alternations expression were observed 82...
Objective Many female patients with nasopharyngeal carcinoma (NPC) desire to reproduce after treatment. To evaluate the outcomes of subsequent pregnancy NPC and explore prognostic effects in women.
Abstract Numerous studies have revealed severe damage to male fertility from acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, raising concerns about the potential adverse impact on reproductive function of disease 2019 (COVID‐19) vaccine developed based virus. Interestingly, there are several researchers who studied COVID‐19 mRNA since then but come up with conflicting results. As a near‐ideal candidate for mass immunization programs, inactivated SARS‐CoV‐2 has been widely...
We aimed to determine the preventive and therapeutic efficacy of modified manual chest compression (MMCC), a novel noninvasive device-independent method, in reducing oxygen desaturation events patients undergoing upper gastrointestinal endoscopy under deep sedation.A total 584 outpatients who underwent sedation during were enrolled. In cohort, 440 randomized MMCC group (patients received when their eyelash reflex disappeared, M1 group) or control (C1 group). 144 with Sp o2 < 95% subsequently...
In the present study, relationship between academic achievements and participation in a sports team adolescents has been identified using nationally representative data. The study sample was created by referring to U.S. Youth Risk Behavior Surveillance 2019 cycle, of which were eligible samples current study. A self-reported questionnaire used assess (0, one, two, three or more teams) performance (mostly A, mostly B, C, E, F). Controlling variables included sex, age, grade, race/ethnicity,...
Alterations of empathy for others' pain among patients with chronic remained inconsistent. Here, applying a capsaicin-based ongoing model on healthy participants, this study investigated how first-hand influences empathic reactions to vicarious stimuli. Healthy participants were randomly treated topical capsaicin cream (capsaicin group) or hand (control the left forearm. Video clips showing limbs in painful and non-painful situations used induce responses. The group showed greater neural...
Growing evidence has suggested that time-varying functional connectivity between different brain regions might underlie the dynamic experience of pain. This study used a novel, data-driven framework to characterize interactions large-scale networks during sustained pain by estimating recurrent patterns phase-synchronization. Resting-state magnetic resonance imaging signals were collected from 50 healthy participants before (once) and after (twice) onset was induced topical application...
Gap junctions regulate proper kidney function by facilitating intercellular communication, vascular conduction, and tubular purinergic signaling. However, no clear relationship has been described between gap-junction acute injury induced the endotoxin lipopolysaccharide (LPS).Normal rat epithelial cells (NRK52E cells) were seeded at high low densities to promote or impede formation, respectively, establish distinctive levels of communication in culture. Cells then challenged with LPS various...
Backgound: Pepsin immunohistochemical (IHC) staining is a promising diagnostic approach of laryngopharyngeal reflux (LPR). The interarytenoid mucosa has been proved to be an effective biopsy area.Objectives: To investigate whether positive result pepsin IHC in laryngeal lesions can predict LPR.Methods: study included 136 patients with cancer or vocal cord leukoplakia. 24 h multichannel intraluminal impedance-pH (MII-pH) was performed before operation, and on pathological sections after...
Abstract Trichinella spiralis is an important foodborne parasitic nematode distributed worldwide that infects humans and animals. Glutaminase (GLS) gene in the glutamine-dependent acid resistance (AR) system; however, its role T. muscle larvae (ML) remains unclear. The present study aimed to characterize GLS (TsGLS) assess function ML AR both vitro vivo using RNA interference. results indicated native TsGLS (72 kDa) was recognized by anti-rTsGLS serum at stage; moreover, immunofluorescence...
Patients with lung ischemia-reperfusion injury (LIRI), involving cytokines, including interleukin (IL)-6 and IL-8, display poor clinical outcomes. Isoflurane displays protective effects against in numerous organs. In the present study, of isoflurane on LIRI were investigated vitro using a hypoxia-reoxygenation (HR) cell model. The mRNA expression levels specific genes analyzed by reverse transcription-quantitative PCR protein measured ELISA western blotting. Cell apoptosis proliferation...