A5044575977- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Biotin and Related Studies
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Calpain Protease Function and Regulation
- Chronic Lymphocytic Leukemia Research
Oregon Health & Science University
2022-2024
University of Alabama at Birmingham
2023
Vollum Institute
2023
VA Portland Health Care System
2023
Portland VA Medical Center
2023
Stanford University
2023
University of California, San Francisco
2020-2023
Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to actin cytoskeleton. Mutations in Dag1 or genes required for its glycosylation result dystroglycanopathy, type of congenital muscular dystrophy characterized by wide range phenotypes including muscle weakness, brain defects, and cognitive impairment. We investigated interneuron (IN) development, synaptic function, associated seizure susceptibility multiple mouse models reflect phenotypic...
Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to actin cytoskeleton. Mutations in Dag1 or genes required for its glycosylation result dystroglycanopathy, type of congenital muscular dystrophy characterized by wide range phenotypes including muscle weakness, brain defects, and cognitive impairment. We investigated interneuron (IN) development, synaptic function, associated seizure susceptibility multiple mouse models reflect phenotypic...
Normal hematopoiesis requires constant prolific production of different blood cell lineages by multipotent hematopoietic stem cells (HSC). Stem- and progenitor- need to balance dormancy with proliferation. How genetic alterations impact frequency, lineage potential, metabolism HSC is largely unknown. Here, we compared induced expression KRAS
ABSTRACT Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to actin cytoskeleton. Mutations in Dag1 or genes required for its glycosylation result dystroglycanopathy, type of congenital muscular dystrophy characterized by wide range phenotypes including muscle weakness, brain defects, and cognitive impairment. We investigated interneuron (IN) development, synaptic function, associated seizure susceptibility multiple mouse models reflect phenotypic...
Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to actin cytoskeleton. Mutations in Dag1 or genes required for its glycosylation result dystroglycanopathy, type of congenital muscular dystrophy characterized by wide range phenotypes including muscle weakness, brain defects, and cognitive impairment. We investigated interneuron (IN) development, synaptic function, associated seizure susceptibility multiple mouse models reflect phenotypic...
Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to actin cytoskeleton. Mutations in Dag1 or genes required for its glycosylation result dystroglycanopathy, type of congenital muscular dystrophy characterized by wide range phenotypes including muscle weakness, brain defects, and cognitive impairment. We investigated interneuron (IN) development, synaptic function, associated seizure susceptibility multiple mouse models reflect phenotypic...
Abstract Oncogenic mutations in RAS genes, like KRAS G12D or NRAS , trap Ras the active state and cause myeloproliferative disorder T cell leukemia (T-ALL) when induced bone marrow via Mx1CRE . The exchange factor RASGRP1 is frequently overexpressed T-ALL patients. In lines overexpression of increases flux through RASGTP/RasGDP cycle. Here we expanded expression surveys pediatric generated a RoLoRiG mouse model crossed to determine consequences primary hematopoietic cells....