A5061189859- Neurogenesis and neuroplasticity mechanisms
- Galectins and Cancer Biology
- Immune cells in cancer
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
University of Michigan
2017-2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an has constituted a difficult clinical challenge. The complex, dynamic, inhibitory microenvironment postinjury, which is characterized by proinflammatory signaling from invading leukocytes lack sufficient factors that promote axonal survival elongation, limits regeneration. Herein, we investigated delivery polycistronic vectors, potential to coexpress target distinct barriers...
Triple negative breast cancer (TNBC) is a highly aggressive subtype that lacks effective targeted therapies. Although TNBC not defined by specific therapeutic targets, subset of patients have tumors overexpress cyclins. High cyclin D/E expression catalyzes CDK4/2 activity. In turn, can non-canonically phosphorylate Smad3, key TGFβ signaling intermediate, and this phosphorylation has been associated with the shift from tumor-suppressive to oncogenic pathway action in oncogenesis....
Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and bladder, bowel, sexual function. Patients are rarely treated immediately, this delay associated with tissue scar formation can make regeneration at chronic time points more challenging. Herein, we investigated using poly(lactide-co-glycolide) multichannel bridge implanted into SCI following surgical resection necrotic tissue. We characterized dynamic...