Hypoxia is a characteristic of locally advanced solid tumors, resulting from an imbalance between oxygen consumption and supply. In hypoxic increased expression nitroreductase (NTR) detected, therefore, the development NTR-targeted fluorescent probes to selectively efficiently detect hypoxia in vivo utmost importance. this study, probe (1) has been designed tested for effective optical detection NTR vitro vivo. The reduction (1), catalyzed by NTR, resulted changes electron-withdrawn nitrogen...

Summary Background Chloral hydrate, a commonly used sedative in children during noninvasive diagnostic procedures, is associated with side effects like prolonged sedation, paradoxical excitement, delirium, and unpleasant taste. Dexmedetomidine, highly selective α ‐2 agonist, has better pharmacokinetic properties than chloral hydrate. We conducted this prospective, double‐blind, randomized controlled trial to evaluate efficacy of intranasal dexmedetomidine that second oral dose hydrate for...

Abstract Aim To study analgesic effects of dexmedetomidine or sufentanil, both combined with ropivacaine, in epidural analgesia during labor. Methods We recruited 160 primigravidae full‐term pregnancy who received anesthesia labor and randomized them into four groups to receive administration ropivacaine sufentanil (RS 1 RS 2 groups) (RD RD groups). Systolic blood pressure, diastolic pressure heart rate before (T ), 15 min after induction on delivery 3 ) h postpartum 4 together visual...

Dexmedetomidine (DEX) could serve as an adjuvant analgesic during cancer therapies. Abnormal expression of microRNAs (miRNAs) lead to development. This study was aimed explore the roles DEX in ovarian (OC) OC cell lines SKOV3 and HO-8910 were treated with DEX, after which development miR-185, SOX9, Wnt/β-catenin pathway measured. DEX-treated cells transfected miR-185 mimic, antisense or + silenced SOX9 further measure growth. The target relation between identified, protein levels detected...

Moderate to deep sedation is required for an auditory brainstem response test when high-intensity stimulation used. Chloral hydrate the most commonly used sedative, whereas intranasal dexmedetomidine increasingly in pediatric non-painful procedural sedations.The aim of this study was compare success rate after oral chloral at 50 mg kg-1 and 3 μg plus buccal midazolam 0.1 test.Children who were recruited randomly assigned receive placebo, or with . The primary outcome successful...

BACKGROUND:The aim of this study was to explore the effect dexmedetomidine (DEX)-mediated insulin-like growth factor 2 (IGF2) signal pathway on immune function and cancer cell invasion migration in rats with ovarian cancer. MATERIAL AND METHODS:Forty were divided into 4 groups: model group, low dose (0.2 μg/kg/hour DEX), medium (1.0 high (5.0 DEX) DEX groups. In addition, 10 Fischer344 selected as a normal group. Human NUTU-19 poorly differentiated epithelial line cells blank group dose,...

This study is to investigate if non-intubated anaesthesia combined with paravertebral nerve block (PVNB) can enhance recovery in children undergoing video-assisted thoracic surgery (VATS).A randomized controlled trial including 60 patients aged 3 8 years old who underwent elective VATS was performed. They were randomly assigned receive PVNB or general tracheal intubation (1:1 ratio). The primary outcome the length of postoperative in-hospital stay. secondary outcomes included emergence time,...

The present study aimed to investigate and compare the analgesic effect safety of ropivacaine or levobupivacaine in combined spinal‑epidural anesthesia during childbirth their effects on neonatal Apgar scores, as well maternal vital signs. A total 615 patients undergoing labor between April 2016 March 2017 were divided into two groups according used for childbirth: group (n=318) (n=297). onset time analgesia was determined pain score visual analog scale assessed at delivery (T3). At...

Dexmedetomidine is an important sedative agent administered as premedication to achieve procedural sedation in children. To describe the correlation between genetic state and concentration of dexmedetomidine, it necessary develop a specific, time-saving economical method for detection dexmedetomidine plasma samples. In this work, ultra-high-performance liquid chromatography (UHPLC)-tandem mass spectrometry has been established validated from pediatric population. After simple liquid-liquid...

<title>Abstract</title> <bold>Purpose: </bold>The lung protective ventilation strategy has been advocated during the laparoscopic perioperative period. However, uncertainty remains as to which mode of mechanical is more appropriate in We hypothesized pressure controlled - volume guaranteed (PCV-VG) a better option than (VCV) <bold>Method: trial was self-controlled study. The period divided into five phases: before induction anesthesia (AWAKE), after (BEGIN), first phase surgery (MIDDLE-1),...

Background: The present work is an effort to develop novel propofol (PPF) and remifentanil (RFT) co-loaded nanoemulsion (NME) for the treatment of anesthetic effects. Methods: PPF/RFT NME was prepared via high-pressure homogenization method. Its physicochemical properties were assessed ensure good quality suitability i.v. administration. We also studied in vivo pharmacokinetics pharmacodynamics dogs with optimized formulation. Results: This study showed that mean particle size 124.2 nm zeta...

Objective To explore the application of Narcotrend-assisted anesthesia in-depth monitor during total intravenous in children. Methods From June to November 2013,a 40 children who underwent abdominal surgery were included study randomly. They divided into Narcotrend group (n = 20) and control 20). All patients received with propofol remifentanil. The adjusted according index (NTI). Those their heart rate(HR), mean arterial pressure (MAP) movement. Changes hemodynamics, durations...

Objective To evaluate the effective dose of dexmedetomidine for prevention emergence agitation after desflurane anesthesia patients undergoing a cleft lip repair surgery in children. Methods Twenty-one American Society Anesthesiology Classification (ASA) Ⅰ orⅡchildren, scheduled elective under general anesthesia, were enrolled study. After induction, was administered before surgery. Emergence (EA) (agitation measured at level 4 or more least once) assessed on arrival postanesthetic...

Objective To investigate the role of nuclear factor-kappa B (NF-κB)signaling pathway in propofol-induced suppression up-regulation inducible nitric oxide synthase (iNOS) gene expression LPSstimulated RAW264.7 cells.Methods cells were purchased from cell bank Chinese Academy Sciences and cultured DMEM culture medium containing 10％ fetal bovine serum.The seeded 6 cm diameter dishes (3 ml/dish) or 6-well plates (2 ml/well) with a density 5 × 105/ml randomly divided into 3 groups ( n =18):...

Objective To determine the minimum alveolar concentration (MAC) of sevoflurane in Chinese neonates.Methods Thirty ASA Ⅰ or Ⅱ neonates,aged ≤ 28 days,with normal body weight,scheduled for elective surgery under general anesthesia,were enrolled study.Anesthesia was induced with inhalation 6.00％ oxygen.The infants were tracheal intubated and mechanically ventilated.The inhaled adjusted to achieve preset end-tidal maintained at this level 20 min.Skin incision then performed.The determined by...

Objective To evaluate the effect of isobaric ropivacaine used in spinal anesthesia on cesarean section. Methods A total 180 cases scheduled for section from August 2012 to April 2013 Guangzhou Women and Children Medical Center were randomly divided into 9 groups each group had 20 cases. Each given 7 mg (group R7),8 mg(group R8),9 R9),10 R10),11 R11),12 R12),13 R13),14 R14), 15 R15),respectively. Every subject was punctured L3~L4 intervertebral space,then injected subarachnoid space....

Objective To investigate the postoperative analgesic effect of levobupivacaine combined with dexmedetomidine applied to infraorbital nerve block for cleft lip repair in children. Methods A total 60 children who were diagnosed as congenital and underwent surgery Guangzhou Women Children′s Medical Center from April July 2016 selected study objects. According random number table, patients divided into 3 groups, LD group (received block), L control normal saline solution 20 cases each...

Objective To study radical cure effect of introducing different doses midazolam anesthesia on postoperative analgesia in patients with thoracoscope lung carcinoma. Methods Between August 2014 and July 2015, choosing 82 cancer our hospital, according to the draw method, they were divided into observation group (41 cases) control patients). Observation treated 0.1 mg/kg induction, given dose 0.05 for induction anesthesia. Two groups preoperative 48 h inflammatory factor levels, blood...

Objective To study curative efficacy of high oxygen liquid one lung ventilation anesthesia in children. Methods 30 children who received therapy from July 2014 to 2016 our hospital were selected as research objects. According random number table, all underwent pulmonary lobectomy, those divided into the A group (n=15) and B (n=15). The after ventilation, was treated with 30 ml (kg·h) speed, constant speed input acetated glygoyle oxygen, while ringer injected same speed.Then...

Objective To evaluate the effects of different fluid therapy protocols on postoperative nausea and vomiting (PONV) in pediatric patients undergoing ambulatory surgery. Methods A total 160 patients, American Society Anesthesiologists physical status Ⅰ or Ⅱ, aged 3-7 yr, weighing 14-24 kg, with body mass index <30 kg/m2, elective lower abdominal surgery, were randomized into Ⅱ groups (n=80 each) using a random number table method.Lactated Ringer′s solution 10 ml·kg-1·h-1 30...

Objective: Cervical cancer (CC) is a serious health problem, causing heavy burden each year worldwide. Long non-coding RNA (lncRNA) implicated in CC progression. This study aims to clarify the underlying mechanism of lncRNA HAND2 AS1 cellular process. Method: LncRNA expression tissues and adjacent was analyzed via Gene Expression Omnibus microarray. The levels HAND2-AS1, microRNA (miR)-21 ALEX1 54 cases tissues, cell lines normal breast cells were detected. malignant biological behaviors...