A5091548707- Heat shock proteins research
- Enzyme Structure and Function
- Protein Structure and Dynamics
- thermodynamics and calorimetric analyses
- Crystallization and Solubility Studies
- Seismic Waves and Analysis
- Research on Leishmaniasis Studies
- X-ray Diffraction in Crystallography
- Seismology and Earthquake Studies
- Methane Hydrates and Related Phenomena
- Computational Drug Discovery Methods
- Biochemical and Molecular Research
- ATP Synthase and ATPases Research
- Trypanosoma species research and implications
- Hemoglobin structure and function
- Toxin Mechanisms and Immunotoxins
- Synthesis and Biological Evaluation
- Generative Adversarial Networks and Image Synthesis
- Insect and Pesticide Research
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Fungal Infections and Studies
- Nanoparticle-Based Drug Delivery
- Fungal and yeast genetics research
- RNA Research and Splicing
Universidade de São Paulo
2015-2024
Universidade Federal de São Carlos
2015-2024
Hospital Universitário Clementino Fraga Filho
2023
Rio de Janeiro Federal Institute of Education, Science and Technology
2023
Robert Bosch (India)
2023
Universidade de Brasília
2022
Ministre de la Santé
2022
National Institute of Science and Technology for Structural Biology and Bioimaging
2021
Hospital das Clínicas da Universidade Federal de Minas Gerais
2013-2015
Instituto do Coração
2014
Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating events through extensive phosphorylation factors from proteins (SR proteins). Previous investigations have described overexpression SRPK1 and SRPK2 leukemia other cancer types, suggesting that they would be useful targets for developing novel antitumor strategies. Herein, we evaluated effect...
The human mitochondrial Hsp70, also called mortalin, is of considerable importance for mitochondria biogenesis and the correct functioning cell machinery. In matrix, mortalin acts in importing folding process nucleus-encoded proteins. vivo deregulation expression and/or function has been correlated with age-related diseases certain cancers due to its interaction p53 protein. spite critical biological roles, structural functional studies on are limited by insoluble recombinant production....
Proteins that belong to the heat shock protein (Hsp) 40 family assist Hsp70 in many cellular functions and are important for maintaining cell viability. A knowledge of structural functional characteristics Hsp40 is therefore essential understanding role chaperone system cells. In this work, we used small angle x-ray scattering analytical ultracentrifugation study two representatives human Hsp40, namely, DjA1 (Hdj2/dj2/HSDJ/Rdj1) from subfamily DjB4 (Hlj1/DnaJW) B, determine their quaternary...
The ubiquitous Hsp90 is critical for protein homeostasis in the cells, stabilizing "client" proteins a functional state. activity depends on its ability to bind and hydrolyze ATP, involving various conformational changes that are regulated by co-chaperones, posttranslational modifications small molecules. Compounds like geldanamycin (GA) radicicol inhibit ATPase occupying ATP binding site, which can lead client degradation also cell growth differentiation protozoan parasites. Our goal was...
Heat shock proteins (HSPs) are ubiquitous polypeptides expressed in all living organisms that participate several basic cellular processes, including protein folding, from which their denomination as molecular chaperones originated. There HSPs, HSPA5, also known 78-kDa glucose-regulated (GRP78) or binding immunoglobulin (BIP) is an ER resident involved the folding of during translocation into this compartment prior to transition Golgi network. HSPA5 detected on surface cells secreted...
Protein folding, refolding and degradation are essential for cellular life regulated by protein homeostatic processes such those that involve the molecular chaperone DnaK/Hsp70 its co-chaperone DnaJ. Hsp70 action is initiated when proteins from DnaJ family bind an unfolded delivery purposes. In eukaryotes, can be divided into two main groups, Type I II, represented yeast cytosolic Ydj1 Sis1, respectively. Although sharing some unique features both members of family, Sis1 structurally...
Mitochondrial Hsp70 is involved in both protein import and folding process, among other essential functions. In mammalian cells, due to its role the malignant it receives name of mortalin. Despite importance mitochondrial homeostasis, mortalin tends self-aggregate vitro vivo, later leads biogenesis failure. Recently, a zinc-finger protein, named Hsp70-escort 1 (Hep1, also called Zim17/TIM15/DNLZ), was described as an human co-chaperone which avoids self-aggregation. Here, we report...
The initiation of Aspergillus fumigatus infection occurs via dormant conidia deposition into the airways. Therefore, conidial germination and subsequent hyphal extension growth occur in a sustained heat shock (HS) environment promoted by host. cell wall integrity pathway (CWIP) essential eukaryotic chaperone Hsp90 are critical for fungi to survive HS. Although A. is thermophilic fungus, mechanisms underpinning HS response not thoroughly described important define its role pathogenesis,...
Heat shock proteins (HSP) are critical elements for the preservation of cellular homeostasis by participating in an array biological processes. In addition, HSP play important role protection from various environmental stresses. part a large family different molecular mass polypeptides, displaying expression patterns, subcellular localizations, and diversity functions. An unexpected observation was detection on cell surface. Subsequent studies have demonstrated that ability to interact...
Leishmaniasis is a group of parasitic diseases with the potential to infect more than 1 billion people; however, its treatment still old and inadequate. In order contribute changing this view, work consisted development complexes derived from MI metal ions thioureas, aiming obtain leishmanicidal agents. The thiourea ligands (HLR) were obtained by reactions p-toluenesulfohydrazide R-isothiocyanates used in complexation AgI AuI, leading formation composition [M(HLR)2]X (M = Ag or Au; X NO3-...