A5011605095- HIV Research and Treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- HIV-related health complications and treatments
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Infectious Encephalopathies and Encephalitis
- Alzheimer's disease research and treatments
- Neurological Complications and Syndromes
- Mosquito-borne diseases and control
- Traumatic Brain Injury Research
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- HIV/AIDS Research and Interventions
- COVID-19 and Mental Health
Tulane University
2020-2025
Temple University
2006-2020
Ark Therapeutic (United States)
2014-2017
Dickinson State University
2008
Children's of Alabama
2005
Research Triangle Park Foundation
2003
Dartmouth–Hitchcock Medical Center
2002
This randomized controlled trial examined the benefits of combining an inhaled corticosteroid, fluticasone propionate (F), with long-acting beta(2)-agonist, salmeterol (S), to treat inflammatory and bronchoconstrictive components chronic obstructive pulmonary disease (COPD). A total 691 patients COPD received combination F S (FSC), (50 mcg), (500 or placebo twice daily via Diskus device for 24 weeks. significantly greater increase in predose FEV(1) at endpoint was observed after FSC (156 ml)...
Abstract We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated proviral copies from latently infected human CD4+ T-cells. Comprehensive assessment whole-genome sequencing eradicated cells ruled out any off-target effects by our technology that might compromise integrity host further showed no effect on several cell health indices including viability, cycle apoptosis. Persistent co-expression Cas9...
Abstract Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development animal models that recapitulate the neuropathological findings autopsied brain tissue from patients who died severe acute respiratory syndrome 2 (SARS-CoV-2) infection critical for elucidating neuropathogenesis and disease. Here, we show neuroinflammation, microhemorrhages, hypoxia, neuropathology is consistent with...
HIV-associated neurocognitive disorders (HAND) describes different levels of impairment, which are a common complication HIV infection. The most severe these, dementia (HIV-D), has decreased in incidence since the introduction combination antiretroviral therapy (cART), while an increase less severe, minor disorder (MND), is now seen. neuropathogenesis HAND not completely understood, however macrophages (MΦ)s/microglia believed to play prominent role development more HIV-D. Here, we report...
Abstract Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-effective vaccines and treatments. Here we investigate the events from acute state up four weeks post infection, in non-human primates (NHP) with heterogeneous pulmonary pathology. We show a robust migration of CD16 expressing monocytes lungs occurring during phase, describe two subsets interstitial macrophages (HLA-DR + CD206 − ): transitional CD11c cell population directly IL-6 levels plasma,...
Abstract Renal macrophages (RMs) participate in tissue homeostasis, inflammation and repair. RMs consist of embryo-derived (EMRMs) bone marrow-derived (BMRMs), but the fate, dynamics, replenishment, functions metabolic states these two RM populations remain unclear. Here we investigate characterize at different ages by conditionally labeling ablating several transgenic lines. We find that expand mature parallel with renal growth after birth, are mainly derived from fetal liver monocytes...
Evidence suggests an association between severe acute respiratory syndrome-cornavirus-2 (SARS-CoV-2) infection and the occurrence of new-onset diabetes. We examined pancreatic expression angiotensin-converting enzyme 2 (ACE2) transmembrane serine protease (TMPRSS2), cell entry factors for SARS-CoV-2, using publicly available single-cell RNA sequencing data sets, tissue from control male female nonhuman primates (NHPs) humans. also SARS-CoV-2 immunolocalization in cells SARS-CoV-2-infected...
Preclinical mouse models that recapitulate some characteristics of coronavirus disease (COVID-19) will facilitate focused study pathogenesis and virus-host responses. Human agniotensin-converting enzyme 2 (hACE2) serves as an entry receptor for severe acute respiratory syndrome (SARS-CoV-2) to infect people via binding envelope spike proteins. Herein we report development characterization a rapidly deployable COVID-19 model. C57BL/6J (B6) mice expressing hACE2 in the lung were transduced by...
Monocytes and macrophages play a prominent role in the establishment of HIV-1 infection, virus dissemination, development viral reservoirs. Like T cells, display immune polarization that can promote or impair adaptive immunity. We hypothesize dysregulation monocyte/macrophage activation differentiation may dysfunction contribute to AIDS pathogenesis. Using flow cytometry, we analyzed frequency monocyte subsets human immunodeficiency type 1 (HIV-1) infection relative seronegative controls,...
Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations the post-acute sequelae SARS-CoV-2. Our understanding metabolic decline after acute COVID-19 remains unclear due to lack animal models. Here, we report a non-human primate model SARS-CoV-2 using infected African green monkeys. Using this model, identify dysregulated blood chemokine signature during that correlates with elevated persistent hyperglycemia four months post-infection. Hyperglycemia...
CD16
Infection with the etiological agent of COVID-19, SARS-CoV-2, appears capable impacting cognition in some patients post-acute sequelae SARS-CoV-2 (PASC). To evaluate neuropathophysiological consequences infection, we examine transcriptional and cellular signatures Brodmann area 9 (BA9) frontal cortex hippocampal formation (HF) Alzheimer’s disease (AD), SARS-CoV-2-infected AD individuals compared to age- gender-matched neurological cases. Here, show similar alterations neuroinflammation...