A5041635920- Ion Transport and Channel Regulation
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Ion channel regulation and function
- Cancer survivorship and care
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Advanced Glycation End Products research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Childhood Cancer Survivors' Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Renal function and acid-base balance
- Psychosomatic Disorders and Their Treatments
- Neuroscience of respiration and sleep
- Alcohol Consumption and Health Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Causal Inference Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Telomeres, Telomerase, and Senescence
- Health disparities and outcomes
- Intensive Care Unit Cognitive Disorders
Erasmus MC
2025
University of Miami
2019-2024
North Downs Hospital
2024
National Institute of Environmental Health Sciences
2020
Environmental Protection Agency
2020
University of Alabama at Birmingham
2007-2020
University of Florida Health
2019
University of Arizona
2009-2018
Neurobehavioral Systems
2018
Emory University
2011-2015
Post-acute sequelae of SARS-CoV-2 (PASC) is defined as persistent symptoms after apparent recovery from acute COVID-19 infection, also known long-haul. We performed a retrospective review electronic health records (EHR) the University California COvid Research Data Set (UC CORDS), de-identified EHR PCR-confirmed SARS-CoV-2-positive patients in California. The purposes were to (1) describe prevalence PASC, (2) and symptom clusters, (3) identify risk factors for PASC. subjected non-negative...
Abstract Emerging data suggest that the effects of infection with SARS-CoV-2 are far reaching extending beyond those severe acute disease. Specifically, presence persistent symptoms after apparent resolution from COVID-19 have frequently been reported throughout pandemic by individuals labeled as “long-haulers”. The purpose this study was to assess for at days 0-10 and 61+ among subjects PCR-confirmed infection. University California COvid Research Data Set (UC CORDS) used identify 1407...
Abstract Background There is a compelling unmet medical need for biomarker-based models to risk-stratify patients with acute respiratory distress syndrome. Effective stratification would optimize participant selection clinical trial enrollment by focusing on those most likely benefit from new interventions. Our objective was develop prognostic, model predicting mortality in adult Methods This secondary analysis using cohort of 252 mechanically ventilated subjects the diagnosis Survival day 7...
Postacute sequelae of SARS-CoV2 (PASC) infection is an emerging global health crisis, variably affecting millions worldwide. PASC has no established treatment. We describe 2 cases in response to opportune administration over-the-counter antihistamines, with significant improvement symptoms and ability perform activities daily living. Future studies are warranted understand the potential role histamine pathogenesis explore clinical benefits antihistamines treatment PASC.
SARS-CoV-2 (COVID-19) has caused over 80 million infections 973,000 deaths in the United States, and mutations are linked to increased transmissibility. This study aimed determine effect of variants on respiratory features, mortality, vaccination status. A retrospective review medical records (n = 55,406 unique patients) using University California Health COvid Research Data Set (UC CORDS) was performed identify status, mortality from 01/01/2020 04/26/2022. Variants were identified CDC data...
To determine the frequency, timing, and duration of post-acute sequelae SARS-CoV-2 infection (PASC) their impact on health function. Post-acute is an emerging major public problem that poorly understood has no current treatment or cure. PASC a new syndrome yet to be fully clinically characterised. Descriptive cross-sectional survey (n = 5163) was conducted from online COVID-19 survivor support groups who reported symptoms for more than 21 days following infection. Participants background...
Despite known advantages, the use of biobehavioral approaches in nursing research remains limited. The purposes this article are to (1) present applications stress and inflammation various health conditions as examples concepts (2) stimulate similar future research. Under a conceptual framework, studies on selective inflammatory biomarkers cardiovascular, cancer, pulmonary reviewed summarized. Inflammation underlies many diseases, is significant source increased inflammation. Biobehavioral...
Abstract IMPORTANCE Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) is a major public health concern. Studies suggest that 1 in 3 infected with may develop PASC, including those without initial symptoms or mild COVID-19 disease. 1, 2 OBJECTIVE To evaluate the timing, duration, and impacts PASC reported by large group primarily non-hospitalized survivors. DESIGN, SETTING, AND PARTICIPANTS A survey 5,163 survivors reporting for more than 21 days following infection. Participants were...
Advancements in cancer have increased survival rates leading to a paradigm shift such that is considered chronic disease, necessitating an evaluation of our understanding survivorship (CS). For this purpose, comprehensive literature search was performed, using CINAHL, MEDLINE, and PUBMED from 2000-2021. Drawing the concepts literature, salient factors affect CS across populations were identified proposed model developed. This paper describes Cancer Survivorship Model (CSM). The CSM...
The receptor for advanced glycation end-products (RAGE), a multiligand member of the Ig family, may play crucial role in regulation lung fluid balance. We quantified soluble RAGE (sRAGE), decoy isoform, and (AGEs) from bronchoalveolar lavage smokers nonsmokers, tested hypothesis that AGEs regulate balance through protein kinase C (PKC)-gp91(phox) signaling to epithelial sodium channel (ENaC). Human samples showed increased (9.02 ± 3.03 μg versus 2.48 0.53 μg), lower sRAGE (1,205 292 pg/ml...
β-Adrenergic receptors (β-AR) increase epithelial sodium channel (ENaC) activity to promote lung fluid clearance. However, the effect of selective β-AR agonist on highly cation (HSC) channels or nonselective (NSC) in alveolar type 1 (T1) and 2 (T2) cells is unknown. We hypothesized that stimulation with β -AR (denopamine) (terbutaline) would HSC and/or NSC cells. performed single-channel measurements from T1 T2 accessed rat slices. Terbutaline (20 μM) increased ENaC (open probability, NP o )...
Long-haul COVID-19, also called post-acute sequelae of SARS-CoV-2 (PASC), is a new illness caused by infection and characterized the persistence symptoms. The purpose this cross-sectional study was to identify distinct significant temporal pattern PASC symptoms (symptom type onset) among nationwide sample survivors (n = 5652). randomly sorted into two independent samples for exploratory (EFA) confirmatory factor analyses (CFA). Five factors emerged from EFA: (1) cold flu-like symptoms, (2)...
Chronic alcohol consumption is associated with increased incidence of ICU-related morbidity and mortality, primarily from acute respiratory distress syndrome (ARDS). However, the mechanisms involved are unknown. One explanation that regulates epithelial sodium channels (ENaC) via oxidant signaling to promote a pro- injury environment. We used small rodent models mimic chronic tested hypothesis ethanol (EtOH) would affect lung fluid clearance by up-regulating ENaC activity in lung....
ABSTRACT Exosomes are nano‐sized vesicles that secreted into the extracellular environment. These contain various biological effector molecules can regulate intracellular signaling pathways in recipient cells. The aim of this study was to examine a correlation between exosomal cathepsin B activity and receptor for advanced glycation end‐products (RAGE). Type 1 alveolar epithelial (R3/1) cells were treated with or without hydrogen peroxide exosomes isolated from cell conditioned media...
Amiloride-sensitive epithelial Na(+) channels (ENaC) regulate fluid balance in the alveoli and are regulated by oxidative stress. Since glutathione (GSH) is predominant antioxidant lungs, we proposed that changes redox potential (Eh) would alter cell signaling have an effect on ENaC open probability (Po). In present study, used single channel patch-clamp recordings to examine of stress, via direct application disulfide (GSSG), activity. We found a linear decrease activity as GSH/GSSG Eh...
Cigarette smoke contains high levels of reactive species. Moreover, cigarette can induce cellular production oxidants. The purpose this study was to determine the effect extract (CSE)-derived oxidants on epithelial sodium channel (ENaC) activity in alveolar type 1 (T1) and 2 (T2) cells measure corresponding rates fluid clearance mice receiving a tracheal instillation CSE. Single-channel patch clamp analysis T1 T2 demonstrate that CSE exposure increases ENaC (NPo), measured as product number...