A5007192172- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Gene Regulatory Network Analysis
- Bone and Joint Diseases
- Cellular Mechanics and Interactions
- Bone Metabolism and Diseases
- Pancreatic function and diabetes
- Bone health and treatments
- Cell Image Analysis Techniques
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
University of British Columbia
2020-2024
Canada's Michael Smith Genome Sciences Centre
2022
Abstract The development of vascular networks in microfluidic chips is crucial for the long-term culture three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or tissue explants. Despite rapid advancement microvascular network systems and organoid technologies, vascularizing organoids-on-chips remains a challenge engineering. Most existing devices poorly reflect complexity vivo flows require complex technical set-ups. Considering these constraints, we develop platform to...
An organoid is defined as an engineered multicellular in vitro tissue that mimics its corresponding vivo organ such it can be used to study aspects of a culture dish. The breadth and application human pluripotent stem cell (hPSC)-derived research have advanced significantly include the brain, retina, tear duct, heart, lung, intestine, pancreas, kidney, blood vessels, among several other tissues. development methods for generation microvessels, specifically, has opened way modeling vessel...
ABSTRACT The development of vascular networks on-chip is crucial for the long-term culture three-dimensional cell aggregates such as organoids, spheroids, tumoroids, and tissue explants. Despite rapid advancement microvascular network systems organoid technology, vascularizing organoids-on-chips remains a challenge in engineering. Moreover, most existing microfluidic devices poorly reflect complexity vivo flows require complex technical settings to operate. Considering these constraints, we...
ABSTRACT The emergence of germ layers in embryos during gastrulation is a key developmental milestone. How morphogenetic signals engage the regulatory networks responsible for early embryonic tissue patterning incompletely understood. To understand this, we developed gene network (GRN) model human pluripotent stem cell (hPSC) lineage commitment and embedded it into ‘cellular’ agents that respond to dynamic signalling microenvironment. We found cellular pattern order, composition, dynamics...
Abstract The emergence of the anterior-posterior body axis during early gastrulation constitutes a symmetry-breaking event, which is key to development bilateral organisms, and its mechanism remains poorly understood. Two-dimensional gastruloids constitute simple robust framework study developmental events in vitro. Although spontaneous symmetry breaking has been observed three dimensional (3D) gastruloids, mechanisms behind this phenomenon are We thus set out explore whether controllable 2D...