A5057213590- Cancer Mechanisms and Therapy
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Gestational Trophoblastic Disease Studies
- Liver Disease Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
Wuhan Institute of Physics and Mathematics
2019-2021
Chinese Academy of Sciences
2021
University of Chinese Academy of Sciences
2019
RSK4 promotes invasiveness and drug resistance in lung bladder cancer inhibition of this kinase shows therapeutic potential.
Abstract Chronic hepatitis B Virus (HBV) infection has high morbidity, pathogenicity and unclear pathogenesis. To elucidate the relationship between HBV replication host phospholipid metabolites, we measured 10 classes of phospholipids in serum infected patients cells using ultra performance liquid chromatograph-triple quadruple mass spectrometry. We found that levels phosphatidylcholine (PC), phosphatidylethanolamine, lyso-phosphatidic acid were increased HBsAg (+) compared with (−), while...
In recent years, tumor microenvironment (TME) has been recognized as potential targets for treatment and the vascular system is one of such targets. Fusing truncated tissue factor (tTF) with pH low insertion peptides (pHLIP), tTF-pHLIP, can target vessels owing to its acidic TME cause vessel occlusion by blood clotting subsequently effectively inhibit growth. To evaluate bioeffects, we exposed tTF-pHLIP normal mice xenograft B16F10 analyzed metabolic profiling various tissues biofluids...