Brenda Chang

ORCID: 0000-0003-4868-8230
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About
Contact & Profiles
Research Areas
  • Shoulder Injury and Treatment
  • Cardiac, Anesthesia and Surgical Outcomes
  • CAR-T cell therapy research
  • Shoulder and Clavicle Injuries
  • Intensive Care Unit Cognitive Disorders
  • Hip disorders and treatments
  • Sports injuries and prevention
  • Hemodynamic Monitoring and Therapy
  • Orthopaedic implants and arthroplasty
  • Osteoarthritis Treatment and Mechanisms
  • Immunotherapy and Immune Responses
  • Knee injuries and reconstruction techniques
  • Lower Extremity Biomechanics and Pathologies
  • Sepsis Diagnosis and Treatment
  • Anesthesia and Sedative Agents
  • Total Knee Arthroplasty Outcomes
  • Pain Management and Opioid Use
  • Viral Infectious Diseases and Gene Expression in Insects
  • Cardiac Arrest and Resuscitation
  • Anesthesia and Pain Management
  • Healthcare Decision-Making and Restraints
  • Respiratory Support and Mechanisms
  • Renal function and acid-base balance
  • Nerve Injury and Rehabilitation
  • Patient Safety and Medication Errors

Rusk Rehabilitation
2023

City of Hope
2016-2020

Atrium Medical Cente
2019

City Of Hope National Medical Center
2014-2018

Beckman Research Institute
2018

Hospital for Special Surgery
2016-2018

UC San Diego Health System
2018

Brigham and Women's Hospital
2014-2018

NYU Langone Health
2018

VA San Diego Healthcare System
2017

The American Shoulder and Elbow Surgeons (ASES) questionnaire was developed to provide a standardized method for evaluating shoulder function. Previous studies have determined the clinical responsiveness of this outcome measure heterogenous populations or patients with nonoperatively treated rotator cuff disease. Currently, our knowledge, no exist that establish clinically relevant change in ASES score after arthroplasty.We asked: (1) What are minimal important difference (MCID) substantial...

10.1007/s11999-016-4968-z article EN Clinical Orthopaedics and Related Research 2016-07-08

The minimal clinically important difference (MCID) has been defined in orthopaedics and is the smallest change that a patient considers meaningful. Less known about improvements perceives as considerable, or substantial clinical benefit (SCB). For young, highly functioning cohort with femoroacetabular impingement (FAI), SCB an measure of success.To derive for FAI treatment identify outcome score thresholds variables predictive SCB.Cohort study (diagnosis); Level evidence, 2.The modified...

10.1177/0363546516687541 article EN The American Journal of Sports Medicine 2017-02-01

There is increased emphasis on efficiently administering patient-reported outcome measures (PROMs). The International Hip Outcome Tool-12 (iHOT-12) a short-form version of the iHOT-33, and relatively little known about clinically significant outcomes using iHOT-12.The purpose this study was to define minimal important difference (MCID) patient acceptable symptomatic state (PASS) for iHOT-12 identify predictors achieving these psychometric end points in patients undergoing arthroscopic...

10.1007/s11420-018-9646-0 article EN HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery 2018-11-15

Recent studies have found that depression is associated with increased pain and impairment following lower-extremity arthroplasty; however, this association has not been investigated for total shoulder arthroplasty. The objective of study was to investigate the between patient-reported outcomes arthroplasty.A prospectively collected institutional registry queried consecutive patients who underwent arthroplasty osteoarthritis from 2007 2013 baseline minimum 2-year postoperative American...

10.2106/jbjs.16.00541 article EN Journal of Bone and Joint Surgery 2017-04-19

Minimal clinically important difference (MCID) defines the minimum degree of quantifiable outcome improvement that a patient perceives as result an intervention or in process healing. Substantial clinical benefit (SCB) amount is needed for to feel substantially better. Little known about when significant achieved.To investigate time-dependent nature MCID and SCB after hip arthroscopy femoroacetabular impingement (FAI).Cohort study; Level evidence, 2.An institutional preservation registry was...

10.1177/0363546518786480 article EN The American Journal of Sports Medicine 2018-08-01

This study examines the impact of procedural locations and types anesthetics on patient outcomes in non-operating room anesthesia (NORA) locations. The National Anesthesia Clinical Outcomes Registry database was examined to compare OR NORA anesthetic complications demographics.The for all procedures from 2010 2013. A total 12,252,846 cases were analyzed, with 205 practices contributing information, representing 1494 facilities 7767 physician providers. Cases separated basis procedure...

10.1097/pts.0000000000000156 article EN Journal of Patient Safety 2015-04-08

The aims of this study are (i) to report on the rates subsequent surgery following hip arthroscopy and (ii) identify prognostic variables associated with revision surgery, survival complication rates. Statewide Planning Research Cooperative System database, a census hospital admissions ambulatory in New York State, was used cases primary arthroscopy. Demographic information or arthroplasty were collected. risks modeled use age, sex, procedure surgeon volume as risk factors. Survival analyses...

10.1093/jhps/hnx018 article EN cc-by Journal of Hip Preservation Surgery 2017-06-26

Background Consumer-driven healthcare and an increasing emphasis on quality metrics have encouraged patient engagement in the rating of healthcare. As such, online physician websites become mainstream may play a potential role future policy. Questions/Purposes The purpose this study was to evaluate ratings for US sports medicine surgeons, determine predictors positive analyze inter-website scoring correlation. Methods American Orthopedic Society Sports Medicine (AOSSM) member directory...

10.1007/s11420-016-9520-x article EN HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery 2016-08-17

Background: Mosaicplasty and fresh osteochondral allograft transplantation (OCA) are popular cartilage restoration techniques that involve the single-stage implantation of viable, mature hyaline cartilage–bone dowels into chondral lesions knee. Recently, there has been greater focus on what represents a clinically relevant change in outcomes reporting, commonly applied metrics for measuring clinical significance include minimal important difference (MCID) substantial benefit (SCB). Purpose:...

10.1177/0363546518808030 article EN The American Journal of Sports Medicine 2018-11-27

Background: Lower extremity overuse injuries are common among runners, especially first-time marathoners. Hip abductor and quadriceps strengthening is often recommended to reduce running-related injuries. Hypothesis: A 12-week strength training program would decrease the rate of resulting in marathon noncompletion improve race finishing time. Study Design: Randomized trial. Level Evidence: 2. Methods: Twelve weeks before New York City Marathon, runners age 18 years older were randomized into...

10.1177/1941738119877180 article EN Sports Health A Multidisciplinary Approach 2019-10-23

Introduction The analysis of malpractice claims can provide risk managers with a detailed view patient mortality and morbidity. data comes from many institutions, encompasses diverse group practitioners practice settings, contains clinical information. Analysis help identify patterns injury, factors, rare sentinel events. Methods We examined most recent anesthesia closed collected by Doctors Company, large national insurer. analyzed between 2007 2012. Each claim underwent review physician...

10.1002/jhrm.21156 article EN Journal of Healthcare Risk Management 2014-09-01

For the treatment of femoral condyle cartilage defects with osteochondral allograft transplantation (OCA), many surgeons have relaxed their graft-recipient size-matching criteria given limited supply. However, since anteroposterior (AP) length is typically correlated radius curvature for a condyle, large mismatch in AP can indicate corresponding curvature, leading to articular incongruity after implantation.To evaluate association between and clinical outcomes OCA.Case-control study; Level...

10.1177/0363546518782939 article EN The American Journal of Sports Medicine 2018-07-09

The first clinical case of transient traumatic locked-in syndrome is presented. state lasted for 3 months. patient's neurologic deficit and the abnormal auditory evoked responses pointed to a lesion involving left pons ventral midbrain. caused by damage brain stem structures can be thus it may have better prognosis than secondary occlusion basilar artery.

10.1159/000115110 article EN European Neurology 1979-01-01

Background Chondral lesions in the patellofemoral compartment represent a difficult entity to treat among active patients, with no clear consensus on optimal treatment strategy. The purpose of this study was review functional outcomes patients >40 years old primary osteochondral who underwent cartilage restoration procedure structural graft. Methods Following institutional board approval, 35 treated for chondral or injuries were retrospectively identified. Seventeen (47%) had prior...

10.1177/1947603516665441 article EN Cartilage 2016-08-24

Blood and marrow transplantation (BMT) is a potentially curative therapy for number of malignant nonmalignant diseases. Multiple variables, including age, comorbid conditions, disease, disease stage, prior therapies, degree donor-recipient matching, type transplantation, dose intensity the preparative regimen, affect both morbidity mortality. Despite tremendous gains in supportive care, BMT remains high-risk medical therapy. A critically ill recipient may require transfer to an intensive...

10.1016/j.bbmt.2015.07.026 article EN cc-by-nc-nd Biology of Blood and Marrow Transplantation 2015-08-01

As the world of cellular therapy expands to include immune effector cell (IEC) products such as commercial chimeric antigen receptor (CAR) T cells, quality management (QM) professionals are faced with creating either new IEC stand-alone programs or expand existing hematopoietic transplantation (HCT) promote patient safety and be aligned quality, regulatory, accreditation requirements. The team at City Hope (COH) recently expanded HCT program and, in doing so, implemented regulatory...

10.1016/j.bbmt.2020.03.021 article EN cc-by-nc-nd Biology of Blood and Marrow Transplantation 2020-05-19

The Boston Marathon terrorist bombing that occurred on April 15, 2013 illustrates the importance of a cohesive, efficient management for operating room and perioperative services. Conceptually, emotional intelligence (EI) is form social used by individuals in leadership positions to monitor feelings emotions their team while implementing strategic plan.To describe experience caring victims at large tertiary care center provide examples demonstrating EI its role patient flow overall care.A...

10.5055/ajdm.2014.0144 article EN American Journal of Disaster Medicine 2014-04-01

Preoperative patient-reported outcome measures (PROMs) have been shown to influence outcomes after total shoulder arthroplasty (TSA), although little is known about this relationship. An institutional registry was retrospectively queried for preoperative and 2-year postoperative 12-Item Short Form Health Survey (SF-12) American Shoulder Elbow Surgeons (ASES) scores patients who underwent anatomic TSA (aTSA) or reverse (rTSA). PROMs were evaluated their effect on patient achievement of...

10.3928/01477447-20210618-09 article EN Orthopedics 2021-07-01

Abstract Xeroderma pigmentosum ( XP ) is a rare, autosomal recessive disease involving defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma AFX neoplasm typically found setting extensive sun exposure or therapeutic radiation, s are rarely associated with children . We report case 13‐year‐old Guatemalan girl type C variant who developed one largest reported on child's finger.

10.1111/pde.12852 article EN Pediatric Dermatology 2016-04-04

Whether shoulder arthroplasty can be performed on an outpatient basis depends appropriate patient selection. The purpose of this study was to identify risk factors for adverse events (AEs) following and generate predictive models improve This a retrospective review prospectively collected data using single institution registry as well the American College Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database, including subjects undergoing hemiarthroplasty, total (TSA),...

10.3928/01477447-20201216-01 article EN Orthopedics 2020-12-29
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