A5100418281- Congenital Heart Disease Studies
- Pectus Deformity Diagnosis and Treatment
- Tracheal and airway disorders
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Vascular anomalies and interventions
- Mitochondrial Function and Pathology
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Gout, Hyperuricemia, Uric Acid
- Injury Epidemiology and Prevention
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Sarcoma Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Hearing, Cochlea, Tinnitus, Genetics
- Vascular Tumors and Angiosarcomas
- Gastrointestinal disorders and treatments
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
Shanghai Cancer Institute
2025
Renji Hospital
2024-2025
Shanghai Jiao Tong University
2021-2025
Wuhan No.1 Hospital
2025
Capital Medical University
2014-2024
Chongqing Medical University
2018-2024
Children's Hospital of Chongqing Medical University
2018-2024
Ruijin Hospital
2021-2024
Beijing Children’s Hospital
2012-2024
China International Science and Technology Cooperation
2018-2023
Abstract The pathogenesis of age‐related hearing loss (ARHL) remains unclear. OPA1 is the sole fusion protein currently known to be situated in inner mitochondrial membrane, which pivotal for maintaining normal function. While it has already been demonstrated that mutations may lead hereditary deafness, its involvement occurrence and development ARHL not previously explored. In our study, we constructed D‐gal‐induced senescent HEI‐OC1 cells cochlea C57BL/6J mice with a mutated SUMOylation...
Pneumocytis pneumonia (PCP) is a life-threatening disease in non-HIV infected children. However, there have been few studies that examined the clinical characteristics associated with PCP and outcomes for these pediatric patients.A retrospective review was performed over 10-year period to evaluate outcome of children diagnosed at Beijing Children's Hospital China.A total 60 were included study. The overall mortality 41.7% (25/60). Underlying diseases connective tissue (n = 23; 38.3%),...
Presbycusis contributes to cognitive decline and Alzheimer's disease. However, most research in this area involves clinical observations statistical modeling, few studies have examined the relationship between hearing loss molecular changes that lead dysfunction. The present study investigated whether dementia absence of aging noise using a mouse model severe bilateral induced by kanamycin (1000 mg/kg) furosemide (400 mg/kg). Immunohistochemistry, silver staining, immunofluorescence...
Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, which risk factors mediate this unknown. Methods: intelligence (n=269,867), (n=510,795) cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals European ethnicities. genetic associations these (UK Biobank, n=397,867) analyzed using linkage...
Purpose: Develop and validate an accessible prediction model using machine learning (ML) to predict the risk of chemotherapy-induced myelosuppression (CIM) in children with Wilms' tumor (WT) before chemotherapy is administered, enabling early preventive management. Methods: A total 1433 cycles 437 WT who received our hospital from January 2009 March 2022 were retrospectively analyzed. Demographic data, clinicopathological characteristics, hematology blood biochemistry baseline results,...
ABSTRACT Postoperative pain and tumor recurrence are critical challenges following malignant resection. To address these issues, we developed a supramolecular gel delivery system loaded with ropivacaine microcrystals (RopC Gel). Using PEG400 as the solvent, successfully screened identified matrix materials capable of forming hydrogels through heating–cooling process. By strategically leveraging hydrophilic hydrophobic properties matrix, controlled its mechanical strength degradation rate by...
Tetralogy of Fallot (TOF) is a congenital heart disease characterized by abnormal cardiomyocyte differentiation in the right ventricular outflow tract (RVOT), and HA117 novel long noncoding RNA (lncRNA) with anti-differentiation roles. To investigate potential association TOF, we collected 84 RVOT tissues from patients TOF. We determined expression samples TOF clinical data to conduct cross-sectional short-term follow-up study. McGoon ratio, Nakata index, left end-diastolic volume index...
Abstract Background Acute renal injury (AKI) after aortic arch reconstruction with cardiopulmonary bypass leads to of multiple organs and increases perioperative mortality. The study was performed explore risk factors for AKI. We aim develop a prediction model that can be used accurately predict AKI through machine learning (ML). Methods A retrospective analysis on 134 patients who were treated at our hospital from January 2002 2022. Risk compositive evaluated comprehensive analyses. Six...
OBJECTIVES: To comprehensively describe the incidence, process of care, outcomes, and variation among different age groups pediatric out-of-hospital cardiac arrest (OHCA) in China. DESIGN: The Baseline Investigation Out-of-Hospital Cardiac Arrest (BASIC-OHCA) is a prospective, multicenter, population-based registry emergency medical services (EMS)-assessed OHCA SETTING: A total 25 monitoring sites all seven geographical regions were included, covering population (age ≤ 19) around 22.3...
Abstract Leiomyosarcoma of the inferior vena cava (IVCL) is a rare retroperitoneal tumor. We report two cases level II (middle level, renal veins to hepatic veins) IVCL, who underwent en bloc resection with reconstruction bilateral or left venous return using prosthetic grafts. In our cases, IVCL documented be occluded preoperatively, therefore, radical tumor and/or right kidney was performed and distal end resected without caval reconstruction. None patients developed edema acute failure...
Abstract Objectives The occurrence of pulmonary infection after congenital heart disease (CHD) surgery can lead to significant increases in intensive care cardiac unit (CICU) retention time, medical expenses, and risk death risk. We hypothesized that patients with a high could be screened out as early surgery. Hence, we developed validated the first prediction model verify our hypothesis. Methods Patients who underwent CHD from October 2012 December 2017 Children’s Hospital Chongqing Medical...
The incidence of clinical adverse events after tetralogy Fallot (TOF) repair remains high. This study was performed to explore risk factors for and develop a prediction model through machine learning (ML) forecast the TOF repair.A total 281 participants who were treated with cardiopulmonary bypass (CPB) at our hospital from January 2002 2022 included in study. Risk explored by composite comprehensive analyses. Five artificial intelligence (AI) models used ML build screen out best performance...
Background: The optimal timing of surgery for pectus excavatum (PE) is controversial. A large proportion children will not undergo before puberty. However, untimely may lead to a decline in the children’s social adaptation and competitiveness because have already developed psychological physiological impairments due PE at an early age. study retrospectively compared academic performance undergoing Nuss procedure versus nonsurgical observation. Methods: This retrospective real-world research...
Surgical repair of pectus excavatum is typically carried out immediately prior to puberty. However, at the time surgery, some psychosocial issues, such as behavioural disorders may already have developed and likelihood these resolving after surgery unclear. For this reason, surgeons choose perform surgical an earlier age in children. The study retrospectively compares rate children undergoing Nuss procedure 4 vs. 10 years age. We also attempted develop a model predict risk year-old...
Background: Reliable brain protection during aortic arch surgery remains a formidable surgical challenge. Various cerebral techniques have been used in the clinic; however, there is no consensus regarding which strategy best. We will perform network meta-analysis (NMA) focusing on permanent neurological deficits (PND) and perioperative mortality associated with 4 major strategies surgery. Methods: literature search of MEDLINE, EMBASE, Cochrane Library, PubMed databases. The primary outcomes...
To summarize the diagnosis and treatment of 13 patients with mixed-type total anomalous pulmonary venous connection (TAPVC) propose another classification for mixed TAPVC.A retrospective review TAPVC undergoing repair at a single institution was conducted between January 2010 November 2019. The made in all using echocardiography combined computed tomography angiography. According to anatomy, there were 3 type I (2 + 2 veins), 10 II (3 1 veins) no III TAPVC. Correspondingly, patient "SVC VV"...
Abstract Objectives A retrospective study was performed to summarize the experience of transcatheter closure patent ductus arteriosus (PDA) through right femoral vein under guidance transesophageal echocardiography (TEE). Methods From January 2019 September 2021, 75 children who underwent PDA TEE were included. The guide wire and delivery sheath inserted into descending aorta via vein, occluder subsequently deployed. After discharge, all patients required for outpatient follow-ups at 1, 3, 6...